Heidi Smith-Vaughan

Menzies School of Health Research

Registered to supervise postgraduate research

20012020

Research output per year

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Research Output

2020

10-Valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine (PHiD-CV10) versus 13-valent pneumococcal conjugate vaccine (PCV13) as a booster dose to broaden and strengthen protection from otitis media (PREVIX_BOOST) in Australian Aboriginal children: Study protocol for a randomised controlled trial

Oguoma, V. M., Wilson, N., Mulholland, K., Santosham, M., Torzillo, P., McIntyre, P., Smith-Vaughan, H., Balloch, A., Chatfield, M., Lehmann, D., Binks, M. J., Chang, A., Carapetis, J., Krause, V., Andrews, R., Snelling, T., Licciardi, P., Morris, P. & Leach, A. J., 24 May 2020, In : BMJ Open. 10, 5, p. 1-11 11 p., e033511.

Research output: Contribution to journalArticle

Open Access
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Comparative genomic analysis identifies X-factor (haemin)-independent Haemophilus haemolyticus: a formal re-classification of 'Haemophilus intermedius'

Harris, T. M., Price, E. P., Sarovich, D. S., Nørskov-Lauritsen, N., Beissbarth, J., Chang, A. B. & Smith-Vaughan, H. C., 1 Jan 2020, In : Microbial Genomics. 6, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
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4 Downloads (Pure)

Panel 4: Recent advances in understanding the natural history of the otitis media microbiome and its response to environmental pressures

Marsh, R. L., Aho, C., Beissbarth, J., Bialasiewicz, S., Binks, M., Cervin, A., Kirkham, L. A. S., Lemon, K. P., Slack, M. P. E. & Smith-Vaughan, H. C., Mar 2020, In : International Journal of Pediatric Otorhinolaryngology. 130, Supplement 1, p. 1-15 15 p., 109836.

Research output: Contribution to journalArticle

2019

A comparison of flocked nylon swabs and non-flocked rayon swabs for detection of respiratory bacteria in nasopharyngeal carriage in Australian Indigenous children

Wigger, C., Morris, P. S., Stevens, M., Smith-Vaughan, H., Hare, K., Beissbarth, J. & Leach, A. J., 1 Feb 2019, In : Journal of Microbiological Methods. 157, p. 47-49 3 p.

Research output: Contribution to journalArticle

Open Access
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7 Downloads (Pure)

Do combined upper airway cultures identify lower airway infections in children with chronic cough?

Hare, K., Chang, A., Smith-Vaughan, H., Bauert, P., Spain, B., Beissbarth, J. & Grimwood, K., Jun 2019, In : Pediatric Pulmonology. 54, 6, p. 907-913 7 p.

Research output: Contribution to journalArticle

Efficacy of oral amoxicillin–clavulanate or azithromycin for non-severe respiratory exacerbations in children with bronchiectasis (BEST-1): a multicentre, three-arm, double-blind, randomised placebo-controlled trial

Goyal, V., Grimwood, K., Ware, R. S., Byrnes, C. A., Morris, P. S., Masters, I. B., McCallum, G. B., Binks, M. J., Smith-Vaughan, H., O'Grady, K. A. F., Champion, A., Buntain, H. M., Schultz, A., Chatfield, M., Torzillo, P. J. & Chang, A. B., 1 Sep 2019, In : The Lancet Respiratory Medicine. 7, 9, p. 791-801 11 p.

Research output: Contribution to journalArticle

HOspitalised Pneumonia Extended (HOPE) Study to reduce the long-term effects of childhood pneumonia: protocol for a multicentre, double-blind, parallel, superiority randomised controlled trial

Chang, A., Fong, S. M., Yeo, T., Ware, R. S., Mccallum, G., Nathan, A., Ooi, M. H., de Bruyne, J., Byrnes, C. A., LEE, B., Nachiappan, N., Saari, N., Torzillo, P., Smith-Vaughan, H., Morris, P., Upham, J. W. & Grimwood, K., 24 Apr 2019, In : BMJ Open. 9, 4, p. 1-9 9 p., e026411.

Research output: Contribution to journalArticle

Open Access
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5 Downloads (Pure)

Method for culturing Candidatus Ornithobacterium hominis

Lawrence, K. A., Harris, T. M., Salter, S. J., Hall, R. W., Smith-Vaughan, H. C., Chang, A. B. & Marsh, R. L., Apr 2019, In : Journal of Microbiological Methods. 159, April, p. 157-160 4 p.

Research output: Contribution to journalArticle

Molecular Signatures of Non-typeable Haemophilus influenzae Lung Adaptation in Pediatric Chronic Lung Disease

Aziz, A., Sarovich, D. S., Nosworthy, E., Beissbarth, J., Chang, A. B., Smith-Vaughan, H., Price, E. P. & Harris, T. M., 16 Jul 2019, In : Frontiers in Microbiology. 10, July, p. 1-13 13 p., 1622.

Research output: Contribution to journalArticle

Open Access
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Multiple Respiratory Microbiota Profiles Are Associated With Lower Airway Inflammation in Children With Protracted Bacterial Bronchitis

Marsh, R. L., Smith-Vaughan, H. C., Chen, A. C. H., Marchant, J. M., Yerkovich, S. T., Gibson, P. G., Pizzutto, S. J., Hodge, S., Upham, J. W. & Chang, A. B., Apr 2019, In : Chest. 155, 4, p. 778-786 9 p.

Research output: Contribution to journalArticle

Open Access
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Povidone-iodine ear wash and oral cotrimoxazole for chronic suppurative otitis media in Australian aboriginal children: Study protocol for factorial design randomised controlled trial

Wigger, C., Leach, A. J., Beissbarth, J., Oguoma, V., Lennox, R., Nelson, S., Patel, H., Chatfield, M., Currie, K., Coates, H., Edwards, K., Smith-Vaughan, H., Hare, K., Torzillo, P., Tong, S. & Morris, P., 27 Jul 2019, In : BMC Pharmacology and Toxicology. 20, p. 1-6 6 p., 46.

Research output: Contribution to journalArticle

Open Access
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Open Access
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Open Access
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2018

Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children

Smith-Vaughan, H., Binks, M., Beissbarth, J., Chang, A., Mccallum, G., Mackay, I. M., Morris, P., Marsh, R., Torzillo, P. J., Wurzel, D. F., Grimwood, K., Nosworthy, E., Gaydon, J. E., Leach, A., Machunter, B., Chatfield, M., Sloots, T. P. & Cheng, A. C., 2018, In : European Journal of Clinical Microbiology and Infectious Diseases. 37, 9, p. 1785–1794 10 p.

Research output: Contribution to journalArticle

Defining lower airway bacterial infection in children with chronic endobronchial disorders

Hare, K., Pizzutto, S., Chang, A., Smith-Vaughan, H., Mccallum, G., Beissbarth, J., Versteegh, L. & Grimwood, K., Feb 2018, In : Pediatric Pulmonology. 53, 2, p. 224-232 9 p.

Research output: Contribution to journalArticle

Evaluation of different infant vaccination schedules incorporating pneumococcal vaccination (The Vietnam Pneumococcal Project): protocol of a randomised controlled trial

Temple, E., Toan, N. T., Uyen, D. Y., Balloch, A., Bright, K., Cheung, Y. B., Licciardi, P., Nguyen, C. D., Phuong, N. T. M., Satzke, C., Smith-Vaughan, H., Vu, T. Q. H., Huu, T. N. & Mulholland, E. K., 8 Jun 2018, In : BMJ Open. 8, 6, p. 1-11 11 p., e019795.

Research output: Contribution to journalComment/debate

Open Access
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How low can we go? The implications of low bacterial load in respiratory microbiota studies

Marsh, R., Nelson, M. T., Pope, C., Leach, A., Hoffman, L., Chang, A. & Smith-Vaughan, H., 5 Jul 2018, In : Pneumonia. 10, p. 1-9 9 p., 7.

Research output: Contribution to journalReview article

Open Access
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9 Downloads (Pure)
Open Access
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2 Downloads (Pure)

The clinical, immunological and microbiological impact of the 10-valent pneumococcal-Protein D conjugate vaccine in children with recurrent protracted bacterial bronchitis, chronic suppurative lung disease and bronchiectasis: a multi-centre, double-blind, randomised controlled trial

O'Grady, K. F., Chang, A., Cripps, A., Mulholland, E. K., Smith-Vaughan, H., Wood, N., Danchin, M., Thornton, R., Wilson, A., Torzillo, P. J., Morris, P., Richmond, P., Rablin, S., Arnold, D., Connor, A., Goyal, V., Stoney, T., Perrett, K. & Grimwood, K., 2 Nov 2018, In : Human Vaccines and Immunotherapeutics. 14, 11, p. 2768-2779 12 p.

Research output: Contribution to journalArticle

Open Access
2017

Culture of non-typeable Haemophilus influenzae from the nasopharynx: Not all media are equal

Harris, T. M., Rumaseb, A., Beissbarth, J., Barzi, F., Leach, A. J. & Smith-Vaughan, H. C., Jun 2017, In : Journal of Microbiological Methods. 137, p. 3-5 3 p.

Research output: Contribution to journalComment/debate

Propensity of pneumococcal carriage serotypes to infect the lower airways of children with chronic endobronchial infections

Hare, K. M., Smith-Vaughan, H. C., Chang, A. B., Pizzutto, S., Petsky, H. L., McCallum, G. B. & Leach, A. J., 1 Feb 2017, In : Vaccine. 35, 5, p. 747-756 10 p.

Research output: Contribution to journalArticle

Simultaneous identification of Haemophilus influenzae and Haemophilus haemolyticus using real-time PCR

Price, E. P., Harris, T. M., Spargo, J., Nosworthy, E., Beissbarth, J., Chang, A. B., Smith-Vaughan, H. C. & Sarovich, D. S., Jun 2017, In : Future Microbiology. 12, 7, p. 585-593 9 p.

Research output: Contribution to journalArticle

Open Access

Streptococcus pneumoniae and chronic endobronchial infections in childhood

Hare, K., Leach, A., Smith-Vaughan, H., Chang, A. & Grimwood, K., Dec 2017, In : Pediatric Pulmonology. 52, 12, p. 1532-1545 14 p.

Research output: Contribution to journalArticle

2016
Open Access
Open Access

Geographic consistency in dominant, non-typeable Haemophilus influenzae genotypes colonising four distinct Australian paediatric groups: a cohort study

Smith-Vaughan, H., Beissbarth, J., Bowman, J., Hare, K., PRICE, E., Pickering, J., Lehmann, D., Chang, A., Morris, P., Marsh, R. & Leach, A., 2016, In : Pneumonia. 8, 13, p. 1-6 6 p.

Research output: Contribution to journalArticle

Open Access
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Limited impact of neonatal or early infant schedules of 7-valent pneumococcal conjugate vaccination on nasopharyngeal carriage of Streptococcus pneumoniae in Papua New Guinean children: A randomized controlled trial

Aho, C., Michael, A., Yoannes, M., Greenhill, A., Jacoby, P., Reeder, J. R., Pomat, W., Saleu, G., Namuigi, P., Phuanukoonnon, S., Smith-Vaughan, H., Leach, A. J., Richmond, P. & Lehmann, D., 1 Dec 2016, In : Vaccine Reports. 6, p. 36-43 8 p.

Research output: Contribution to journalArticle

Open Access
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1 Downloads (Pure)

Protracted Bacterial Bronchitis in Children: Natural History and Risk Factors for Bronchiectasis

Wurzel, D. F., Marchant, J. M., Yerkovich, S. T., Upham, J. W., Petsky, H. L., Smith-Vaughan, H., Masters, B., Buntain, H. & Chang, A. B., Nov 2016, In : Chest. 150, 5, p. 1101-1108 8 p.

Research output: Contribution to journalArticle

Open Access
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19 Downloads (Pure)
Open Access
2015

Deriving accurate microbiota profiles from human samples with low bacterial content through post-sequencing processing of Illumina MiSeq data

Jervis-Brady, J., Leong, L. E. X., Marri, S., Smith, R. J., Choo, J. M., Smith-Vaughan, H., Nosworthy, E., Morris, P., O'Leary, S., Rogers, G. & Marsh, R., 2015, In : Microbiome. 3, 19, p. 1-11 11 p.

Research output: Contribution to journalArticle

Open Access
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7 Downloads (Pure)

Detection of Biofilm in Bronchoalveolar Lavage from Children With Non-Cystic Fibrosis Bronchiectasis

Marsh, R., Thornton, R. B., Smith-Vaughan, H., Richmond, P. C., Pizzutto, S. & Chang, A., 2015, In : Pediatric Pulmonology. 50, 3, p. 284-292 9 p.

Research output: Contribution to journalArticle

Emerging drugs for bronchiectasis: An update

Chang, A., Marsh, R., Smith-Vaughan, H. & Hoffman, L., 2015, In : Expert Opinion on Emerging Drugs. 20, 2, p. 277-297 21 p.

Research output: Contribution to journalArticle

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Haemophilus influenzae: Using comparative genomics to accurately identify a highly recombinogenic human pathogen

Price, E. P., Sarovich, D. S., Nosworthy, E., Beissbarth, J., Marsh, R. L., Pickering, J., Kirkham, L. A. S., Keil, A. D., Chang, A. B. & Smith-Vaughan, H. C., 27 Aug 2015, In : BMC Genomics. 16, 1, p. 1-10 10 p., 641.

Research output: Contribution to journalArticle

Open Access
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Nasopharyngeal carriage and macrolide resistance in Indigenous children with bronchiectasis randomized to long-term azithromycin or placebo

Hare, K., Grimwood, K., Chang, A., Chatfield, M., Valery, P., Leach, A., Smith-Vaughan, H., Morris, P., Byrnes, C., Torzillo, P. & CHENG, A., Nov 2015, In : European Journal of Clinical Microbiology and Infectious Diseases. 34, 11, p. 2275-2285 11 p.

Research output: Contribution to journalArticle

Pneumococcal conjugate vaccines PREVenar13 and SynflorIX in sequence or alone in high-risk indigenous infants (PREV-IX_COMBO): protocol of a randomised controlled trial

Leach, A., MULHOLLAND, E. K., Santosham, M., Torzillo, P., Brown, N., McIntyre, P., Smith-Vaughan, H., Skull, S., Balloch, A., Andrews, R., Carapetis, J., McDonnell, J., Krause, V. & Morris, P., Jan 2015, In : BMJ Open. 5, 1, p. 1-10 10 p., e007247.

Research output: Contribution to journalComment/debate

Open Access
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Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine

Leach, A. J., Wigger, C., Hare, K., Hampton, V., Beissbarth, J., Andrews, R., Chatfield, M., Smith-Vaughan, H. & Morris, P. S., 19 Oct 2015, In : BMC Pediatrics. 15, p. 1-13 13 p., 162.

Research output: Contribution to journalArticle

Open Access
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Open Access

The microbiome of otitis media with effusion in Indigenous Australian children

Jervis-Brady, J., Rogers, G., Morris, P., Smith-Vaughan, H., Nosworthy, E., Leong, L. E. X., Smith, R. J., Weyriche, L. S., De Haan, J., Carney, S., Leach, A., O'Leary, S. & Marsh, R., Sep 2015, In : International Journal of Pediatric Otorhinolaryngology. 79, 9, p. 1548-1555 8 p.

Research output: Contribution to journalArticle

Three-weekly doses of azithromycin for Indigenous infants hospitalized with bronchiolitis: a multicentre, randomized, placebo-controlled trial

Mccallum, G., Morris, P., Grimwood, K., MacLennan, C., White, A., Chatfield, M., Sloots, T. P., Mackay, I. M., Smith-Vaughan, H., McKay, C., Versteegh, L., Jacobsen, N., Mobberley, C., Byrnes, C. & Chang, A., Apr 2015, In : Frontiers in Pediatrics. 3, 32, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
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Toward making inroads in reducing the disparity of lung health in Australian Indigenous and New Zealand Māori children

Chang, A., Marsh, R., Upham, J., Hoffman, L., Smith-Vaughan, H., Holt, D., Byrnes, C., Toombs, M., Yerkovich, S., Torzillo, P., O'Grady, K-A. & Grimwood, K., 2015, In : Pediatric Pulmonology. 3, p. 1-6 6 p.

Research output: Contribution to journalEditorial

Open Access
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Upper airway viruses and bacteria detection in clinical pneumonia in a population with high nasal colonisation do not relate to clinical signs

Chang, A., Smith-Vaughan, H., Sloots, T. P., Valery, P., Whiley, D. W., Beissbarth, J. & Torzillo, P., 2015, In : Pneumonia. 6, p. 46-56 11 p.

Research output: Contribution to journalArticle

Open Access
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2014

Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae

Smith-Vaughan, H. C., Chang, A. B., Sarovich, D. S., Marsh, R. L., Grimwood, K., Leach, A. J., Morris, P. S. & Price, E. P., Feb 2014, In : Clinical and Vaccine Immunology. 21, 2, p. 250-252 3 p.

Research output: Contribution to journalArticle

Open Access

Adenovirus species C is associated with chronic suppurative lung diseases in children

Wurzel, D., Mackay, I. M., Marchant, J., Wang, C., Yerkovich, S., Upham, J., Smith-Vaughan, H., Petsky, H. & Chang, A., 2014, In : Clinical Infectious Diseases. 59, 1, p. 34-40 7 p.

Research output: Contribution to journalArticle

Open Access

A PCR-High-Resolution Melt Assay for Rapid Differentiation of Nontypeable Haemophilus influenzae and Haemophilus haemolyticus

Pickering, J., Binks, M., Beissbarth, J., Hare, K., Kirkham, L-A. S. & Smith-Vaughan, H., Feb 2014, In : Journal of Clinical Microbiology. 52, 2, p. 663-667 5 p.

Research output: Contribution to journalArticle

Open Access

Diversity of Nontypeable Haemophilus influenzae strains colonizing Australian Aboriginal and non-Aboriginal children

Pickering, J., Smith-Vaughan, H., Beissbarth, J., Bowman, J., Wiertsema, S. P., Riley, T., Leach, A., Richmond, P. C., Lehmann, D. & Kirkham, L-A. S., May 2014, In : Journal of Clinical Microbiology. 52, 5, p. 1352-1357 6 p.

Research output: Contribution to journalArticle

Open Access

Global phylogenomic analysis of nonencapsulated Streptococcus pneumoniae reveals a deep-branching classic lineage that is distinct from multiple sporadic lineages

Hilty, M., Wüthrich, D., Salter, S. J., Engel, H., Campbell, S., Sá-Leão, R., De Lencastre, H., Hermans, P., Sadowy, E., Turner, P., Chewapreecha, C., Diggle, M., Pluschke, G., McGee, L., Eser, Ö. K., Low, D. E., Smith-Vaughan, H., Endimiani, A., Ffer, M. K., Dupasquier, M. & 8 others, Beaudoing, E., Weber, J., Bruggmann, R., Hanage, W. P., Parkhill, J., Hathaway, L. J., Hlemann, K. M. & Bentley, S. D., 2014, In : Genome Biology and Evolution. 6, 12, p. 3281-3294 14 p.

Research output: Contribution to journalArticle

Open Access
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