Projects per year
Personal profile
Research interests
The human spleen as a reservoir for Plasmodium species
-Mechanisms underlying splenic accumulation of malaria parasites and its endosplenic lifecycle
-Splenic Plasmodium dormancy and reduced drug susceptibility: implications in malaria elimination
-Evaluation of peripheral markers to estimate the hidden splenic reservoir in human malaria
-Mechanisms of splenomegaly, splenic red cell congestion and its contribution to malarial anemia
-Splenic mechanisms driving and/or maintaining malaria tolerance of innate cells
- Splenic malaria burden in Africa: high transmission settings, dry vs wet season, magnitude of accumulation vs other geopgraphical regions
- Role of the human spleen in erythropoiesis and reticulocyte biology
- Risks of malaria and other clinical outcomes after splenectomy in malaria endemic areas: Informing policy for management of splenectomised patients
- The roles of platelets, red cell interactions, extracellular traps and host immune cells in human malaria
- Extracellular traps in children with non-cystic fibrosis bronchiectasis
Education/Academic qualification
PhD, Role of the spleen, platelets and neutrophils in human malaria
2 Mar 2015 → 10 Apr 2019
Award Date: 10 Apr 2019
Bachelor, Bachelor of Science (First-class Honors in Biochemistry), University of Western Australia
Award Date: 29 Mar 2011
Bachelor, Bachelor of Science (Molecular Biology and Biotechnology), University of Western Australia
Award Date: 17 Mar 2010
External positions
Research Fellow, Burnet Institute
12 Feb 2026 → …
Research Member, Telethon Kids Institute
1 Jan 2024 → …
Research Fellow, Papuan Health and Community Development Foundation
3 May 2022 → …
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Projects
- 1 Finished
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Steven Kho - OzEMalaR – Australia Europe Malaria Research Cooperative Travel Award Funding Assistance
Kho, S. (Principal Investigator/Chief Investigator A)
1/08/14 → 1/01/15
Project: Research
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Chronic Malaria Is Associated With Trauma-related Splenic Rupture Requiring Splenectomy
Shanti, P. A. I., Alexander, K., Candrawati, F., Andries, B., Kambuaya, N. N., Rini, H., Amelia, A. R., Puspitasari, A. M., Amalia, R., Rahmayenti, D. A., Leonardo, L., Prayoga, P., Trianty, L., Pava, Z., Kenangalem, E., Auburn, S., Price, R. N., Laksanawati, I. S., Buffet, P. A. & Noviyanti, R. & 3 others, , Mar 2026, In: The Journal of infectious diseases. 233, 3, p. e740–e744 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure) -
Splenic accumulation of intact Plasmodium ovale sensu lato-infected red blood cells in a patient presenting with splenic rupture
Benabdelmoumen, G., Itani, O., Joste, V., Houzé, S., Hardy, D., Bavozet, F., Sylla, M., Kho, S., Anstey, N. M., Consigny, P. H., Sissoko, A. & Buffet, P., Jan 2026, In: PLoS Neglected Tropical Diseases. 20, 1, p. 1-7 7 p., e0013897.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
The role of the spleen in red blood cell loss caused by malaria: A mathematical model
Moss, R., Dini, S., Kho, S., Barber, B. E., Buffet, P. A., Rajasekhar, M., Price, D. J., Anstey, N. M. & Simpson, J. A., 1 Jan 2026, In: PLoS Computational Biology. 22, 1, p. 1-21 21 p., e1013865.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
BioMalPar at 21 – a coming of age for malaria research and interventions
Aniweh, Y., Dziekan, J., Jore, M. M., Kho, S., Mancio-Silva, L., Merrick, C. J., Nahrendorf, W., Ralph, S. A., Vaughan, A. M. & Verhoef, J. M. J., Sept 2025, In: Trends in Parasitology. 41, 9, p. 703-708 6 p.Research output: Contribution to journal › Comment/debate › peer-review
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Characterisation of Plasmodium vivax lactate dehydrogenase dynamics in P. vivax infections
Cao, P., Kho, S., Grigg, M. J., Barber, B. E., Piera, K. A., William, T., Poespoprodjo, J. R., Jang, I. K., Simpson, J. A., McCaw, J. M., Anstey, N. M., McCarthy, J. S. & Britton, S., Dec 2024, In: Communications Biology. 7, 1, p. 1-11 11 p., 355.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Link opens in a new tab Citations (Scopus)53 Downloads (Pure) -
Neutrophil activation, acute lung injury and disease severity in Plasmodium knowlesi malaria
Tan, A. F., Sakam, S. S. B., Piera, K., Rajahram, G. S., William, T., Barber, B. E., Anstey, N. M., Grigg, M. J. & Kho, S., 16 Aug 2024, In: PLoS Neglected Tropical Diseases. 18, 8, p. 1-19 19 p., e0012424.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)34 Downloads (Pure) -
Platelets mediate the clearance of senescent red blood cells by forming prophagocytic platelet-cell complexes
Ningtyas, D. C., Leitner, F., Sohail, H., Thong, Y. L., Hicks, S. M., Ali, S., Drew, M., Javed, K., Lee, J., Kenangalem, E., Poespoprodjo, J. R., Anstey, N. M., Rug, M., Choi, P. Y. I., Kho, S., Gardiner, E. E. & McMorran, B. J., 8 Feb 2024, In: Blood. 143, 6, p. 535 - 547 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Link opens in a new tab Citations (Scopus)86 Downloads (Pure)
Press/Media
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Study suggests immature red blood cells in spleen are targeted for invasion by P. vivax — ScienceDaily
Minigo, G., Price, R. N., Kho, S. & Anstey, N.
2/06/21
1 item of Media coverage
Press/Media: Research
Thesis
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Roles of platelets, neutrophils and the spleen in human malaria
Kho, S. (Author), Anstey, N. (Supervisor) & Yeo, T. (Supervisor), Nov 2018Student thesis: Doctor of Philosophy (PhD) - CDU
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