Fatigue, sleep disturbance, and depression are frequent concurrent symptoms during cancer treatment or with disease progression in breast cancer (BC) survivors. Research demonstrates that somatic acupressure (SA) is a promising approach for managing cancer-related symptoms, but the definite effects, safety, and economic effectiveness of SA for managing the fatigue–sleep disturbance–depression symptom cluster (FSDSC) have not been evaluated yet. This doctoral research will be a Phase III three-arm sham-controlled RCT to evaluate the clinical efficacy, safety, and economic effectiveness of SA for FSDSC management in BC survivors. A 19-week randomized, partially blinded trial comparing true SA with sham SA daily for seven weeks versus usual care with a 12-week follow-up will be conducted.
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