The epidemiology of youth type 2 diabetes in Indigenous populations and the contribution of in-utero diabetes exposure on growth outcomes and diabetes risk profile in early childhood

Project: HDR ProjectPhD

Project Details

Description

Youth type 2 diabetes appears to disproportionally affect Indigenous populations worldwide, but the global prevalence is unknown. There are accumulating data to suggest that type 2 diabetes may develop at an earlier age in offspring exposed to hyperglycaemia in pregnancy, particularly those exposed to pre-gestational type 2 diabetes. The associations between in-utero diabetes exposure on early childhood growth, diabetes risk and cardiometabolic parameters are not yet well described.

Aims/Methods:
1) To describe the global prevalence of youth-onset type 2 diabetes in Indigenous populations.
2) To examine the associations of hyperglycaemia in pregnancy with childhood outcomes (growth trajectories, measures of adiposity, diabetes risk and cardiometabolic parameters) at age 5.5 – 8 years. Data will be obtained from the Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) cohort study, which includes children born to mothers across the spectrum of glucose tolerance in pregnancy.
Significance: This project will describe the global disease burden of youth type 2 diabetes in Indigenous populations and will investigate the contribution of maternal hyperglycaemia across the spectrum of glucose tolerance on multiple offspring health outcomes.
StatusActive
Effective start/end date6/02/20 → …