Vaccine selective pressures on the microbiology of otitis media in Aboriginal and / or Torres Strait Islander children in northern Australia

  • Beissbarth, Jemima, (Principal Investigator/Chief Investigator A)

Project: HDR ProjectPhD

Project Details

Description

Otitis media is a common childhood illness worldwide. The term ‘otitis media’ describes a spectrum of disease affecting the middle ear, from acute infections to chronic fluid behind the eardrum or discharging through a perforation (hole) in the eardrum. For most children, otitis media does not cause long term problems, however in children with recurrent or chronic otitis media there can be short- and long-term disabling hearing loss, which negatively affects language development, communication, education and later employment outcomes. Research on the three main otopathogens, Streptococcus pneumoniae, non-typeable Haemophilus influenzae and Moraxella catarrhalis is critical to effective prevention and treatment of otitis media.
This project “Vaccine selective pressures on the microbiology of otitis media in Aboriginal and / or Torres Strait Islander children in northern Australia” includes 4 aspects; firstly, the creation of a combined dataset consisting of 25 years of otitis media and respiratory bacteria research, including pneumococcal serotyping and antimicrobial susceptibility profiles. Secondly, the combined dataset will be analysed to describe the long-term trends in nasopharyngeal carriage of S.pneumoniae serotypes and associated antimicrobial resistance associated with increasing valency pneumococcal conjugate vaccines. Thirdly, the possible vaccine selective impact on non-typeable H.influenzae and finally, the analysis of randomised controlled trial data comparing two different pneumococcal conjugate vaccines to a combination schedule of both vaccines on respiratory otopathogens carriage.
These analyses will inform future clinical trial designs that combine vaccines and antibiotics to maximise clinical impact whilst maintaining close monitoring of bacterial populations and emergence of virulent or resistant strains.
StatusActive
Effective start/end date1/01/18 → …