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2019

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, Price, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., 14 Mar 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Antimalarials
Plasmodium falciparum
Plasmodium vivax
Triazines
Parasitemia
4 Downloads (Pure)

Analysis of erroneous data entries in paper based and electronic data collection

Ley, B., Rijal, K. R., Marfurt, J., Adhikari, N. R., Banjara, M. R., Shrestha, U. T., Thriemer, K., Price, R. N. & Ghimire, P., 22 Aug 2019, In : BMC Research Notes. 12, 1, p. 1-6 6 p., 537.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Data acquisition
Nepal
Information Systems
Biomedical Research
Research Design

Genomic Analysis of Plasmodium vivax in Southern Ethiopia Reveals Selective Pressures in Multiple Parasite Mechanisms

Auburn, S., Getachew, S., Pearson, R. D., Amato, R., Miotto, O., Trimarsanto, H., Zhu, S. J., Rumaseb, A., Marfurt, J., Noviyanti, R., Grigg, M. J., Barber, B., William, T., Goncalves, S. M., Drury, E., Sriprawat, K., Anstey, N. M., Nosten, F., Petros, B., Aseffa, A. & 3 others, McVean, G., Kwiatkowski, D. P. & Price, R. N., 1 Dec 2019, In : Journal of Infectious Diseases. 220, 11, p. 1738-1749 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Plasmodium vivax
Ethiopia
Parasites
Chloroquine
Immune Evasion
2 Downloads (Pure)

Malaria morbidity and mortality following introduction of a universal policy of artemisinin-based treatment for malaria in Papua, Indonesia: A longitudinal surveillance study

Kenangalem, E., Poespoprodjo, J. R., Douglas, N. M., Burdam, F. H., Gdeumana, K., Chalfein, F., Prayoga, Thio, F., Devine, A., Marfurt, J., Waramori, G., Yeung, S., Noviyanti, R., Penttinen, P., Bangs, M. J., Sugiarto, P., Simpson, J. A., Soenarto, Y., Anstey, N. M. & Price, R. N., 29 May 2019, In : PLoS Medicine. 16, 5, p. 1-23 23 p., 1002815.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Indonesia
Malaria
Longitudinal Studies
Morbidity
Mortality

Short-course primaquine for the radical cure of Plasmodium vivax malaria: a multicentre, randomised, placebo-controlled non-inferiority trial

Taylor, W. R. J., Thriemer, K., von Seidlein, L., Yuentrakul, P., Assawariyathipat, T., Assefa, A., Auburn, S., Chand, K., Chau, N. H., Cheah, P. Y., Dong, L. T., Dhorda, M., Degaga, T. S., Devine, A., Ekawati, L. L., Fahmi, F., Hailu, A., Hasanzai, M. A., Hien, T. T., Khu, H. & 25 others, Ley, B., Lubell, Y., Marfurt, J., Mohammad, H., Moore, K. A., Naddim, M. N., Pasaribu, A. P., Pasaribu, S., Promnarate, C., Rahim, A. G., Sirithiranont, P., Solomon, H., Sudoyo, H., Sutanto, I., Thanh, N. V., Tuyet-Trinh, N. T., Waithira, N., Woyessa, A., Yamin, F. Y., Dondorp, A., Simpson, J. A., Baird, J. K., White, N. J., Day, N. P. & Price, R. N., 14 Sep 2019, In : The Lancet. 394, 10202, p. 929-938 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Primaquine
Vivax Malaria
Placebos
Recurrence
Glucosephosphate Dehydrogenase
2018

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria": Antimicrob Agents Chemother

Brunschwig, C., Lawrence, N., Taylor, D., Abay, E., Njoroge, M., Basarab, G. S., Le Manach, C., Paquet, T., Gonzalez Cabrera, D., Nchinda, A. T., de Kock, C., Wiesner, L., Denti, P., Waterson, D., Blasco, B., Leroy, D., Witty, M. J., Donini, C., Duffy, J., Wittlin, S. & 28 others, White, K. L., Charman, S. A., Jimenez-Diaz, M. B., Angulo-Barturen, I., Herreros, E., Gamo, F. J., Rochford, R., Mancama, D., Coetzer, T. L., van der Watt, M. E., Reader, J., Birkholtz, L. M., Marsh, K. C., Solapure, S. M., Burke, J. E., McPhail, J. A., Vanaerschot, M., Fidock, D. A., Fish, P. V., Siegl, P., Smith, D. A., Wirjanata, G., Noviyanti, R., Price, R. N., Marfurt, J., Silue, K. D., Street, L. J. & Chibale, K., 27 Nov 2018, In : Antimicrobial Agents and Chemotherapy. 62, 11, p. 1-2 2 p.

Research output: Contribution to journalComment/debateResearch

Open Access
Plasmodium falciparum
Malaria
12 Downloads (Pure)

Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics

Auburn, S., Benavente, E. D., Miotto, O., Pearson, R. D., Amato, R., Grigg, M. J., Barber, B. E., William, T., Handayuni, I., Marfurt, J., Trimarsanto, H., Noviyanti, R., Sriprawat, K., Nosten, F., Campino, S., Clark, T. G., Anstey, N. M., Kwiatkowski, D. P. & Price, R. N., 3 Jul 2018, In : Nature Communications. 9, 1, p. 1-12 12 p., 2585.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Plasmodium vivax
Malaysia
elimination
Genes
Chloroquine
14 Downloads (Pure)

Laboratory challenges of Plasmodium species identification in Aceh Province, Indonesia, a malaria elimination setting with newly discovered P. knowlesi

Coutrier, F. N., Tirta, Y. K., Cotter, C., Zarlinda, I., González, I. J., Schwartz, A., Maneh, C., Marfurt, J., Murphy, M., Herdiana, H., Anstey, N. M., Greenhouse, B., Hsiang, M. S. & Noviyanti, R., 30 Nov 2018, In : PLoS Neglected Tropical Diseases. 12, 11, p. 1-11 11 p., e0006924.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Plasmodium knowlesi
Plasmodium
Indonesia
Malaria
Polymerase Chain Reaction
13 Downloads (Pure)

Low risk of recurrence following artesunate-Sulphadoxine-pyrimethamine plus primaquine for uncomplicated Plasmodium falciparum and Plasmodium vivax infections in the Republic of the Sudan

Hamid, M. M. A., Thriemer, K., Elobied, M. E., Mahgoub, N. S., Boshara, S. A., Elsafi, H. M. H., Gumaa, S. A., Hamid, T., Abdelbagi, H., Basheir, H. M., Marfurt, J., Chen, I., Gosling, R., Price, R. N. & Ley, B., 16 Mar 2018, In : Malaria Journal. 17, 1, p. 1-14 14 p., 117.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Primaquine
Plasmodium vivax
Sudan
Plasmodium falciparum
Malaria
3 Downloads (Pure)

Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: In vivo therapeutic efficacy and kelch13 molecular marker surveillance

Grigg, M. J., William, T., Piera, K. A., Rajahram, G. S., Jelip, J., Aziz, A., Menon, J., Marfurt, J., Price, R. N., Auburn, S., Barber, B. E., Yeo, T. W. & Anstey, N. M., 10 Dec 2018, In : Malaria Journal. 17, 1, p. 1-8 8 p., 463.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Malaysia
Plasmodium falciparum
Parasites
Therapeutics
Malaria
8 Downloads (Pure)

Quantifying primaquine effectiveness and improving adherence: A round table discussion of the APMEN Vivax Working Group

Thriemer, K., Bobogare, A., Ley, B., Gudo, C. S., Alam, M. S., Anstey, N. M., Ashley, E., Baird, J. K., Gryseels, C., Jambert, E., Lacerda, M., Laihad, F., Marfurt, J., Pasaribu, A. P., Poespoprodjo, J. R., Sutanto, I., Taylor, W. R., Van Den Boogaard, C., Battle, K. E., Dysoley, L. & 78 others, Ghimire, P., Hawley, B., Hwang, J., Khan, W. A., Mudin, R. N. B., Sumiwi, M. E., Ahmed, R., Aktaruzzaman, M. M., Awasthi, K. R., Bardaji, A., Bell, D., Boaz, L., Burdam, F. H., Chandramohan, D., Cheng, Q., Chindawongsa, K., Culpepper, J., Das, S., Deray, R., Desai, M., Domingo, G., Duoquan, W., Duparc, S., Floranita, R., Gerth-Guyette, E., Howes, R. E., Hugo, C., Jagoe, G., Sariwati, E., Jhora, S. T., Jinwei, W., Karunajeewa, H., Kenangalem, E., Lal, B. K., Landuwulang, C., Le Perru, E., Lee, S. E., Makita, L. S., McCarthy, J., Mekuria, A., Mishra, N., Naket, E., Nambanya, S., Nausien, J., Duc, T. N., Thi, T. N., Noviyanti, R., Pfeffer, D., Qi, G., Rahmalia, A., Rogerson, S., Samad, I., Sattabongkot, J., Satyagraha, A., Shanks, D., Sharma, S. N., Sibley, C. H., Sungkar, A., Syafruddin, D., Talukdar, A., Tarning, J., Ter Kuile, F., Thapa, S., Theodora, M., Huy, T. T., Waramin, E., Waramori, G., Woyessa, A., Wongsrichanalai, C., Xa, N. X., Yeom, J. S., Hermawan, L., Devine, A., Nowak, S., Jaya, I., Supargiyono, S., Grietens, K. P. & Price, R. N., 20 Jun 2018, In : Malaria Journal. 17, p. 1-7 7 p., 241.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access
File
Primaquine
Malaria
Vivax Malaria
Health Promotion
Habits
7 Downloads (Pure)

The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen–encoding var genes

Tonkin-Hill, G. Q., Trianty, L., Noviyanti, R., Nguyen, H. H. T., Sebayang, B. F., Lampah, D. A., Marfurt, J., Cobbold, S. A., Rambhatla, J. S., McConville, M. J., Rogerson, S. J., Brown, G. V., Day, K. P., Price, R. N., Anstey, N. M., Papenfuss, A. T. & Duffy, M. F., 12 Mar 2018, In : PLoS Biology. 16, 3, p. 1-40 40 p., e2004328.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Plasmodium falciparum
Transcriptome
transcriptome
malaria
Malaria
5 Downloads (Pure)

Therapeutic response to dihydroartemisinin-piperaquine for P. falciparum and P. Vivax nine years after its introduction in southern Papua, Indonesia

Poespoprodjo, J. R., Kenangalem, E., Wafom, J., Chandrawati, F., Puspitasari, A. M., Ley, B., Trianty, L., Korten, Z., Surya, A. S., Syafruddin, D., Anstey, N., Marfurt, J., Noviyanti, R. & Price, R., Mar 2018, In : American Journal of Tropical Medicine and Hygiene. 98, 3, p. 677-682 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
dihydroartemisinin
Indonesia
Plasmodium falciparum
Malaria
Vivax Malaria
13 Downloads (Pure)

Uct943, a next-generation plasmodium falciparum pi4k inhibitor preclinical candidate for the treatment of malaria

Brunschwig, C., Lawrence, N., Taylor, D., Abay, E., Njoroge, M., Basarab, G. S., Le Manach, C., Paquet, T., Cabrera, D. G., Nchinda, A. T., De Kock, C., Wiesner, L., Denti, P., Waterson, D., Blasco, B., Leroy, D., Witty, M. J., Donini, C., Duffy, J., Wittlin, S. & 28 others, White, K. L., Charman, S. A., Jimenez-Diaz, M. B., Angulo-Barturen, I., Herreros, E., Gamo, F. J., Rochford, R., Mancama, D., Coetzer, T. L., Van der Watt, M. E., Reader, J., Birkholtz, L. M., Marsh, K. C., Solapure, S. M., Burke, J. E., McPhail, J. A., Vanaerschot, M., Fidock, D. A., Fish, P. V., Siegl, P., Smith, D. A., Wirjanata, G., Noviyanti, R., Price, R. N., Marfurt, J., Silue, K. D., Street, L. J. & Chibaleb, K., 1 Sep 2018, In : Antimicrobial Agents and Chemotherapy. 62, 9, p. 1-16 16 p., e00012-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1-Phosphatidylinositol 4-Kinase
Plasmodium falciparum
South Africa
Malaria
Plasmodium
2017
7 Downloads (Pure)

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnädig, N. F., Straimer, J., Fidock, D. A., Shore, E. R., Roberts, N. L., Wong, M. H. L., Hong, W. D., Pidathala, C., Riley, C., Murphy, B., Aljayyoussi, G., Gamo–Benito, F. J., Sanz, L. M., Rodrigues, J., Cortes, C. G., Herreros, E. & 28 others, Angulo-Barturén, I., Jiménez-Díaz, M. B., Bazaga, S. F., Martínez-Martínez, M. S., Campo, B., Sharma, R., Ryan, E., Shackleford, D. M., Campbell, S., Smith, D. A., Wirjanata, G., Noviyanti, R., Price, R. N., Marfurt, J., Palmer, M. J., Copple, I. M., Mercer, A. E., Ruecker, A., Delves, M. J., Sinden, R. E., Siegl, P., Davies, J., Rochford, R., Kocken, C. H. M., Zeeman, A-M., Nixon, G. L., Biagini, G. A. & Ward, S. A., 24 May 2017, In : Nature Communications. 8, p. 1-12 12 p., 15159.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Tetraoxanes
parasites
Antimalarials
mutations
Pharmacodynamics
10 Downloads (Pure)

Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group

Thriemer, K., Ley, B., Bobogare, A. B., Dysoley, L., Alam, M. S., Pasaribu, A. P., Sattabongkot-Prachumsri, J. S. P., Jambert, E., Domingo, G. J., Commons, R., Auburn, S., Marfurt, J., Devine, A., Aktaruzzaman, M. M., Sohel, N., Namgay, R. N., Drukpa, T., Sharma, S. N., Sarawati, E., Samad, I. & 47 others, Theodora, M., Nambanya, S., Ounekham, S., Mudin, R. N. B., Da Thakur, G., Makita, L. S., Deray, R., Lee, S. E., Boaz, L., Danansuriya, M. N., Mudiyanselage, S. D., Chinanonwait, N., Kitchakarn, S., Nausien, J., Naket, E., Duc, T. N., Do Manh, H., Hong, Y. S., Cheng, Q., Richards, J. S., Kusriastuti, R., Satyagraha, A. W., Noviyanti, R., Ding, X. C., Khan, W. A., Swe Phru, C., Guoding, Z., Qi, G., Kaneko, A., Miotto, O., Nguitragool, W., Roobsoong, W., Battle, K., Howes, R. E., Roca-Feltrer, A., Duparc, S., Bhowmick, I. P., Kenangalem, E., Bibit, J. A., Barry, A. E., Sintasath, D., Abeyasinghe, R., Sibley, C. H., McCarthy, J., Von Seidlein, L., Baird, J. K. & Price, R. N., 5 Apr 2017, In : Malaria Journal. 16, 141, p. 1-9 9 p., 141.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access
File
Plasmodium vivax
Glucose-6-Phosphate
Primaquine
Point-of-Care Systems
Malaria
5 Downloads (Pure)

Genetic micro-epidemiology of malaria in Papua Indonesia: Extensive P. vivax diversity and a distinct subpopulation of asymptomatic P. falciparum infections

Pava, Z., Noviyanti, R., Handayuni, I., Trimarsanto, H., Trianty, L., Burdam, F. H., Kenangalem, E., Utami, R. A. S., Tirta, Y. K., Coutrier, F., Poespoprodjo, J. R., Price, R. N., Marfurt, J. & Auburn, S., 1 May 2017, In : PLoS One. 12, 5, p. 1-13 13 p., e0177445.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Epidemiology
Indonesia
Molecular Epidemiology
malaria
genotyping
8 Downloads (Pure)

Genomic characterization of recrudescent plasmodium malariae after treatment with artemether/lumefantrine

Rutledge, G. G., Marr, I., Huang, G. K. L., Auburn, S., Marfurt, J., Sanders, M., White, N. J., Berriman, M., Newbold, C. I., Anstey, N. M., Otto, T. D. & Price, R. N., 1 Aug 2017, In : Emerging Infectious Diseases. 23, 8, p. 1300-1307 8 p.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
File
Plasmodium malariae
Malaria
Clone Cells
Infection
Bites and Stings
2 Downloads (Pure)

Molecular analysis demonstrates high prevalence of chloroquine resistance but no evidence of artemisinin resistance in Plasmodium falciparum in the Chittagong Hill Tracts of Bangladesh

Alam, M. S., Ley, B., Nima, M. K., Johora, F. T., Hossain, M. E., Thriemer, K., Auburn, S., Marfurt, J., Price, R. N. & Khan, W. A., 15 Aug 2017, In : Malaria Journal. 16, p. 1-6 6 p., 335.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Bangladesh
Chloroquine
Plasmodium falciparum
Antimalarials
Mutation
4 Downloads (Pure)

Passively versus actively detected malaria: Similar genetic diversity but different complexity of infection

Pava, Z., Handayuni, I., Trianty, L., Utami, R. A. S., Tirta, Y. K., Puspitasari, A. M., Burdam, F., Kenangalem, E., Wirjanata, G., Kho, S., Trimarsanto, H., Anstey, N., Poespoprodjo, J. R., Noviyanti, R., Price, R. N., Marfurt, J. & Auburn, S., Dec 2017, In : American Journal of Tropical Medicine and Hygiene. 97, 6, p. 1788-1796 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Malaria
Plasmodium vivax
Plasmodium falciparum
Infection
Parasites

Plasmodium falciparum and Plasmodium vivax demonstrate contrasting chloroquine resistance reversal phenotypes

Wirjanata, G., Handayuni, I., Prayoga, P., Leonardo, L., Apriyanti, D., Trianty, L., Wandosa, R., Gobay, B., Kenangalem, E., Poespoprodjo, J. R., Noviyanti, R., Kyle, D. E., Cheng, Q., Price, R. N. & Marfurt, J., 25 Jul 2017, In : Antimicrobial Agents and Chemotherapy. 61, 8, p. 1-10 10 p., e00355.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Plasmodium vivax
Chloroquine
Plasmodium falciparum
Phenotype
L 703606
2016
8 Downloads (Pure)

Analysis of ex vivo drug response data of Plasmodium clinical isolates: The pros and cons of diferent computer programs and online platforms

Wirjanata, G., Handayuni, I., Zaloumis, S., Chalfein, F., Prayoga, P., Kenangalem, E., Poespoprodjo, J. R., Noviyanti, R., Simpson, J., Price, R. & Marfurt, J., 2016, In : Malaria Journal. 15, 1, p. 1-10 10 p., 137.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Plasmodium
Software
Inhibitory Concentration 50
Pharmaceutical Preparations
Antimalarials
1 Downloads (Pure)

Asymptomatic Vivax and Falciparum Parasitaemia with Helminth Co-Infection: Major Risk Factors for Anaemia in Early Life

Burdam, F. H., Hakimi, M., Thio, F., Kenangalem, E., Indrawanti, R., Noviyanti, R., Trianty, L., Marfurt, J., Handayuni, I., Seonarto, Y., DOUGLAS, N. N., Anstey, N., Price, R. & Poespoprodjo, J., 2016, In : PLoS One. 11, 8 , p. 1-15 15 p., e0160917.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Parasitemia
Helminths
parasitemia
Coinfection
mixed infection

A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria

Phillips, M. A., White, K. L., Kokkonda, S., Deng, X., White, J., El Mazouni, F., Marsh, K., Tomchick, D. R., Manjalanagara, K., Rudra, K. R., Wirjanata, G., Noviyanti, R., Price, R. N., Marfurt, J., Shackleford, D. M., Chiu, F. C. K., Campbell, M., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I. & 16 others, Martinez, M. S., Lafuente-Monasterio, M., Kaminsky, W., Silue, K., Zeeman, A. M., Kocken, C., Leroy, D., Blasco, B., Rossignol, E., Rueckle, T., Matthews, D., Burrows, J. N., Waterson, D., Palmer, M. J., Rathod, P. K. & Charman, S. A., 9 Dec 2016, In : ACS Infectious Diseases. 2, 12, p. 945-957 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Malaria
Pharmaceutical Preparations
Vivax Malaria
SCID Mice
Plasmodium
1 Downloads (Pure)

Characterization of blood dendritic and regulatory T cells in asymptomatic adults with sub-microscopic Plasmodium falciparum or Plasmodium vivax infection

Kho, S., Marfurt, J., Handayuni, I., Pava, Z., Noviyanti, R., Kusuma, A., Piera, K., Burdam, F. H., Kenangalem, E., Lampah, D., Engwerda, C., Poespoprodjo, J. R., Price, R., Anstey, N., Minigo, G. & Woodberry, T., 2016, In : Malaria Journal. 15, 1, p. 1-9 9 p., 328.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Downloads (Pure)

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

Le Bihan, A., de Kanter, R., Angulo-Barturen, I., Binkert, C., Boss, C., Brun, R., Brunner, R., Buchmann, S., Burrows, J., Dechering, K. J., Delves, M., Ewerling, S., Ferrer, S., Fischli, C., Gamo–Benito, F. J., Gnädig, N. F., Heidmann, B., Jiménez-Díaz, M. B., Leroy, D., Martínez, M. S. & 20 others, Meyer, S., Moehrle, J. J., Ng, C. L., Noviyanti, R., Ruecker, A., Sanz, L. M., Sauerwein, R. W., Scheurer, C., Schleiferboeck, S., Sinden, R., Snyder, C., Straimer, J., Wirjanata, G., Marfurt, J., Price, R. N., Weller, T., Fischli, W., Fidock, D. A., Clozel, M. & Wittlin, S., 1 Oct 2016, In : PLoS Medicine. 13, 10, e1002138.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Antimalarials
Plasmodium falciparum
Plasmodium vivax
Plasmodium berghei
Parasites
2 Downloads (Pure)

Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

Duffy, M., Noviyanti, R., Tsuboi, T., Feng, ZP., Trianty, L., Sebayang, B., Takashima, E., Sumardy, F., Lampah, D., Turner, L., Lavstsen, T., Fowkes, F. J. I., Siba, P., Rogerson, S., Theander, T., Marfurt, J., Price, R., Anstey, N., Brown, G. & Papenfuss, AT., 2016, In : Malaria Journal. 15, 1, p. 1-12 12 p., 258.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Malaria
Antibodies
Antigenic Variation
Indonesia
Genes
7 Downloads (Pure)

Dihydrofolate-reductase mutations in plasmodium knowlesi appear unrelated to selective drug pressure from putative human-to-human transmission in Sabah, Malaysia

Grigg, M., Barber, B., Marfurt, J., Imwong, M., William, T., Bird, E., Piera, K., Aziz, A., Boonyuen, U., Drakeley, C., Cox, J., White, N. J., Cheng, Q., Yeo, T., Auburn, S. & Anstey, N., 2016, In : PLoS One. 11, 3, p. 1-19 19 p., e0149519.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Plasmodium knowlesi
dihydrofolate reductase
Tetrahydrofolate Dehydrogenase
Malaysia
Borneo

Expression of Plasmodium vivax crt-o is related to parasite stage but not ex vivo chloroquine susceptibility

Pava, Z., Handayuni, I., Wirjanata, G., To, S., Trianty, L., Noviyanti, R., Poespoprodjo, J. R., Auburn, S., Price, R. & Marfurt, J., Jan 2016, In : Antimicrobial Agents and Chemotherapy. 60, 1, p. 361-367 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Plasmodium vivax
Chloroquine
Parasites
Amodiaquine
Pharmaceutical Preparations

Genomic analysis of local variation and recent evolution in Plasmodium vivax

Pearson, R. D., Amato, R., Auburn, S., Miotto, O., Almagro-Garcia, J., Amaratunga, C., Suon, S., Mao, S., Noviyanti, R., Trimarsanto, H., Marfurt, J., Anstey, N. M., WILLIAM, T., Boni, M. F., Dolecek, C., Tran, H. T., White, N. J., Michon, P., Siba, P., Tavul, L. & 24 others, Harrison, G., Barry, A. E., Mueller, I., Ferreira, M. U., Karunaweera, N., Randrianarivelojosia, M., Gao, Q., Hubbart, C., Hart, L., Jeffery, B., Drury, E., Mead, D., Kekre, M., Campino, S., Manske, M., Cornelius, V. J., MacInnis, B., Rockett, K. A., Miles, A., Rayner, J. C., Fairhurst, R. M., Nosten, F., Price, R. N. & Kwiatkowski, D. P., 1 Aug 2016, In : Nature Genetics. 48, 8, p. 959-964 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasmodium vivax
Malaria
Parasites
Genome
Population
7 Downloads (Pure)

Genomic epidemiology of artemisinin resistant malaria

Amato, R., Miotto, O., Woodrow, C. J., Almagro-Garcia, J., Sinha, I., Campino, S., Mead, D., Drury, E., Kekre, M., Sanders, M., Amambua-Ngwa, A., Amaratunga, C., Amenga-Etego, L., Andrianaranjaka, V., Apinjoh, T., Ashley, E., Auburn, S., Awandare, G. A., Baraka, V., Barry, A. & 77 others, Boni, M. F., Borrmann, S., Bousema, T., Branch, O., Bull, P. C., Chotivanich, K., Conway, D. J., Craig, A., Day, N. P., Djimdé, A., Dolecek, C., Dondorp, A. M., Drakeley, C., Duffy, P., Echeverry, D. F., Egwang, T. G., Fairhurst, R. M., Faiz, A., Fanello, C. I., Hien, T. T., Hodgson, A., Imwong, M., Ishengoma, D., Lim, P., Lon, C., Marfurt, J., Marsh, K., Mayxay, M., Michon, P., Mobegi, V., Mokuolu, O. A., Montgomery, J., Mueller, I., Kyaw, M. P., Newton, P. N., Nosten, F., Noviyanti, R., Nzila, A., Ocholla, H., Oduro, A., Onyamboko, M., Ouedraogo, J. B., Phyo, A. P. P., Plowe, C., Price, R. N., Pukrittayakamee, S., Randrianarivelojosia, M., Ringwald, P., Ruiz, L., Saunders, D., Shayo, A., Siba, P., Takala-Harrison, S., Thanh, T. N. N., Thathy, V., Verra, F., Wendler, J., White, N. J., Ye, H., Cornelius, V. J., Giacomantonio, R., Muddyman, D., Henrichs, C., Malangone, C., Jyothi, D., Pearson, R. D., Rayner, J. C., McVean, G., Rockett, K. A., Miles, A., Vauterin, P., Jeffery, B., Manske, M., Stalker, J., Macinnis, B., Kwiatkowski, D. P. & MalariaGEN Plasmodium falciparum Community Project, 4 Mar 2016, In : eLife. 5, MARCH2016, p. 1-29 29 p., e08714.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Epidemiology
Southeastern Asia
Malaria
Geographical regions
Mutation
6 Downloads (Pure)

Submicroscopic and asymptomatic plasmodium parasitaemia associated with significant risk of anaemia in Papua, Indonesia

Pava, Z., Burdam, F. H., Handayuni, I., Trianty, L., Utami, R. A. S., Tirta, Y. K., Kenangalem, E., Lampah, D., Kusuma, A., Wirjanata, G., Kho, S., Simpson, J. A., Auburn, S., Douglas, N. M., Noviyanti, R., Anstey, N. M., Poespoprodjo, J. R., Marfurt, J. & Price, R. N., 1 Oct 2016, In : PLoS One. 11, 10, e0165340.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Plasmodium
Indonesia
Parasitemia
parasitemia
odds ratio
4 Downloads (Pure)

Transfusion-transmitted severe Plasmodium knowlesi malaria in a splenectomized patient with beta-thalassaemia major in Sabah, Malaysia: A case report

Bird, E., Parameswaran, U., Williams, T., Khoo, T., Grigg, M., Aziz, A., Marfurt, J., Yeo, T., Auburn, S., Anstey, N. & Barber, B., 2016, In : Malaria Journal. 15, 1, p. 1-6 6 p., 357.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Plasmodium knowlesi
Plasmodium malariae
beta-Thalassemia
Malaysia
Malaria
2015

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Baragaña, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Martínez, M. S., Bolscher, J. M., Woodland, A., Norval, S. & 43 others, Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Jiménez-Díaz, M. B., Sanz, L. M., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Gamo, F. J., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Fairlamb, A. H., Willis, P. A., Rayner, J. C., Fidock, D. A., Read, K. D. & Gilbert, I. H., 2015, In : Nature. 22, 7556, p. 315-320 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Antimalarials
Proteins
Malaria
Pharmacokinetics
Parasites

Contrasting Ex Vivo efficacies of "Reversed Chloroquine" compounds in chloroquine-resistant Plasmodium falciparum and P. vivax isolates

Wirjanata, G., Sebayang, B., Chalfein, F., Prayoga, P., Handayuni, I., Noviyanti, R., Kenangalem, E., Poespoprodjo, J. R., Burgess, S., Peyton, D. H., Price, R. & Marfurt, J., Sep 2015, In : Antimicrobial Agents and Chemotherapy. 59, 9, p. 5721-5726 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Chloroquine
Plasmodium falciparum
Plasmodium vivax
Malaria
Schizonts
5 Downloads (Pure)

Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination

Noviyanti, R., Farah, C., Utami, R. A. S., Trimarsanto, H., Tirta, Y. K., Trianty, L., Kusuma, A., Sutanto, A., Kosasih, A., Kusriastuti, Hawley, W. A., Laihad, F., Lobo, N., Marfurt, J., Clark, T., Price, R. & Auburn, S., 2015, In : PLoS Neglected Tropical Diseases. 9, 5 1, p. 1-19 19 p., e0003739.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Plasmodium vivax
Falciparum Malaria
Malaria
Indonesia
Linkage Disequilibrium
13 Downloads (Pure)

Potent Ex Vivo activity of naphthoquine and methylene blue against drug-resistant clinical isolates of Plasmodium falciparum and Plasmodium vivax

Wirjanata, G., Sebayang, B., Chalfein, F., Prayoga, P., Handayuni, I., Trianty, L., Kenangalem, E., Noviyanti, R., Campo, B., Poespoprodjo, J. R., Möhrle, J., Price, R. & Marfurt, J., Oct 2015, In : Antimicrobial Agents and Chemotherapy. 59, 10, p. 6117-6124 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Plasmodium vivax
Methylene Blue
Plasmodium falciparum
Pharmaceutical Preparations
Inhibitory Concentration 50

Preserved dendritic cell HLA-DR expression and reduced regulatory T cell activation in Asymptomatic Plasmodium falciparum and P. vivax infection

Kho, S., Marfurt, J., Noviyanti, R., Kusuma, A., Piera, K., Burdam, F. H., Kenangalem, E., Lampah, D., Engwerda, C., Poespoprodjo, J. R., Price, R., Anstey, N., Minigo, G. & Woodberry, T., Aug 2015, In : Infection and Immunity. 83, 8, p. 3224-3232 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
HLA-DR Antigens
Regulatory T-Lymphocytes
Plasmodium falciparum
Dendritic Cells
Malaria
3 Downloads (Pure)

Quantification of Plasmodium ex vivo drug susceptibility by flow cytometry

Wirjanata, G., Handayuni, I., Prayoga, Apriyanti, D., Chalfein, F., Sebayang, B., Kho, S., Noviyanti, R., Kenangalem, E., Campo, B., Poespoprodjo, J. R., Price, R. & Marfurt, J., 2015, In : Malaria Journal. 14, 417, p. 1-10 10 p., 417.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Plasmodium
Flow Cytometry
Plasmodium vivax
Plasmodium falciparum
Inhibitory Concentration 50
2014
43 Downloads (Pure)

KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission

Kuhen, K. L., Chatterjee, A. K., Rottmann, M., Gagaring, K., Borboa, R., Buenviaje, J., Chen, Z., Francek, C., Wu, T., Nagle, A., Barnes, S. W., Plouffe, D., Lee, M. C. S., Fidock, D. A., Graumans, W., Van De Vegte-Bolmer, M., Van Gemert, G. J., Wirjanata, G., Sebayang, B., Marfurt, J. & 18 others, Russell, B., Suwanarusk, R., Price, R. N., Nosten, F., Tungtaeng, A., Gettayacamin, M., Sattabongkot, J., Taylor, J., Walker, J. R., Tully, D., Patra, K. P., Flannery, E. L., Vinetz, J. M., Renia, L., Sauerwein, R. W., Winzeler, E. A., Glynne, R. J. & Diagana, T. T., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 9, p. 5060-5067 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Antimalarials
Malaria
Sporozoites
Plasmodium
Life Cycle Stages
3 Downloads (Pure)

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

Vaidya, A. B., Morrisey, J. M., Zhang, Z., Das, S., Daly, T. M., Otto, T. D., Spillman, N. J., Wyvratt, M., Siegl, P., Marfurt, J., Wirjanata, G., Sebayang, B. F., Price, R. N., Chatterjee, A., Nagle, A., Stasiak, M., Charman, S. A., Angulo-Barturen, I., Ferrer, S., Belén Jiménez-Díaz, M. & 11 others, Martínez, M. S., Gamo, F. J., Avery, V. M., Ruecker, A., Delves, M., Kirk, K., Berriman, M., Kortagere, S., Burrows, J., Fan, E. & Bergman, L. W., 2014, In : Nature Communications. 5, p. 1-10 10 p., 5521.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
homeostasis
parasites
Antimalarials
Plasmodium falciparum
Parasites
2013
Open Access
Plasmodium knowlesi
Vivax Malaria
Plasmodium vivax
Falciparum Malaria
Malaysia
3 Downloads (Pure)

Effective Preparation of Plasmodium vivax Field Isolates for High-Throughput Whole Genome Sequencing

Auburn, S., Marfurt, J., Maslen, G., Campino, S., Ruano-Rubio, V., Manske, M., Machunter, B., Kenangalem, E., Noviyanti, R., Trianty, L., Sebayang, B., Wirjanata, G., Sriprakash, K., Alcock, D., MacInnes, B., Miotto, O., Clark, T., Russell, B., Anstey, N., Nosten, F. & 2 others, Kwiatkowski, D. & Price, R., 2013, In : PLoS One. 8, 1, p. 1-11 11 p., e53160.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Plasmodium vivax
Genes
Throughput
Genome
genome

Quinolone-3-diarylethers: A new class of antimalarial drug

Nilsen, A., LaCrue, A. N., White, K. L., Forquer, I. P., Cross, R. M., Marfurt, J., Mather, M. W., Delves, M. J., Shackleford, D. M., Saenz, F. E., Morrisey, J. M., Steuten, J., Mutka, T., Li, Y., Wirjanata, G., Ryan, E., Duffy, S., Kelly, J. X., Sebayang, B. F., Zeeman, A-M. & 21 others, Noviyanti, R., Sinden, R. E., Kocken, C. H. M., Price, R. N., Avery, V. M., Angulo-Barturen, I., Jiménez-Díaz, M. B., Ferrer, S., Herreros, E., Sanz, L. M., Gamo–Benito, F. J., bathurst, I., Burrows, J. N., Siegl, P., Guy, R. K., Winter, R. W., Vaidya, A. B., Charman, S. A., Kyle, D. E., Manetsch, R. & Riscoe, M. K., 20 Mar 2013, In : Science Translational Medicine. 5, 177, p. 1-13 13 p., 177ra37.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Quinolones
Antimalarials
Parasites
Malaria
4-Quinolones
2012
2 Downloads (Pure)

An Analytical Method for Assessing Stage-Specific Drug Activity in Plasmodium vivax Malaria: Implications for Ex Vivo Drug Susceptibility Testing

Kerlin, D., Boyce, K., Marfurt, J., SIMPSON, J., Kenangalem, E., Cheng, Q., Price, R. & Gatton, M., 2012, In : PLoS Neglected Tropical Diseases. 6, 8, e1772.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Vivax Malaria
Parasites
Chloroquine
Schizonts
Plasmodium vivax

Comparative Ex Vivo Activity of Novel Endoperoxides in Multidrug-Resistant Plasmodium falciparum and P. vivax

Marfurt, J., Chalfein, F., Prayoga, P., Wabiser, Wirjanata, G., Sebayang, B., Piera, K., Wittlin, S., Haynes, R., Mohrle, J., Anstey, N., Kenangalem, E. & Price, R., 2012, In : Antimicrobial Agents and Chemotherapy. 56, 10, p. 5258-5263 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
dihydroartemisinin
Plasmodium falciparum
Plasmodium
Chloroquine
Antimalarials

Phenotypic and genotypic characterisation of drug-resistant Plasmodium vivax

Price, R., Auburn, S., Marfurt, J. & Cheng, Q., 2012, In : Trends in Parasitology. 28, 11, p. 522-529 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasmodium vivax
Drug Resistance
Clinical Trials
Pharmaceutical Preparations
Parasites
2011

Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax

Marfurt, J., Chalfein, F., Prayoga, P., Wabiser, F., Kenangalem, E., Piera, K., Fairlie, D., Tjitra, E., Anstey, N., Andrews, K. & Price, R., 2011, In : Antimicrobial Agents and Chemotherapy. 55, 3, p. 961-966 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Histone Deacetylase Inhibitors
Plasmodium falciparum
Antimalarials
Schizonts
Mefloquine

Ex Vivo Drug Susceptibility of Ferroquine against Chloroquine-Resistant Isolates of Plasmodium falciparum and P. vivax

Marfurt, J., Chalfein, F., Prayoga, P., Wabiser, F., Kenangalem, E., Piera, K., Machunter, B., Tjitra, E., Anstey, N. & Price, R., 2011, In : Antimicrobial Agents and Chemotherapy. 55, 9, p. 4461-4464 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Chloroquine
Plasmodium falciparum
Pharmaceutical Preparations
Amodiaquine
Schizonts

In Vivo and In Vitro Efficacy of Chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia

SISWANTORO, H., Russell, B., RATCLIFF, A., Prasetyorini, Chalfein, F., Marfurt, J., Kenangalem, E., Wuwung, R., Piera, K., Ebsworth, E., Anstey, N., Tjitra, E. & Price, R., 2011, In : Antimicrobial Agents and Chemotherapy. 55, 1, p. 197-202 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Plasmodium malariae
Indonesia
Chloroquine
Trophozoites
Parasites