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  • Amanda Leach
2020

10-Valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine (PHiD-CV10) versus 13-valent pneumococcal conjugate vaccine (PCV13) as a booster dose to broaden and strengthen protection from otitis media (PREVIX_BOOST) in Australian Aboriginal children: Study protocol for a randomised controlled trial

Oguoma, V. M., Wilson, N., Mulholland, K., Santosham, M., Torzillo, P., McIntyre, P., Smith-Vaughan, H., Balloch, A., Chatfield, M., Lehmann, D., Binks, M. J., Chang, A., Carapetis, J., Krause, V., Andrews, R., Snelling, T., Licciardi, P., Morris, P. & Leach, A. J., 24 May 2020, In : BMJ Open. 10, 5, p. 1-11 11 p., e033511.

Research output: Contribution to journalArticle

Open Access
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Panel 6: Otitis media and associated hearing loss among disadvantaged populations and low to middle-income countries

Leach, A. J., Homøe, P., Chidziva, C., Gunasekera, H., Kong, K., Bhutta, M. F., Jensen, R., Tamir, S. O., Das, S. K. & Morris, P., Mar 2020, In : International Journal of Pediatric Otorhinolaryngology. 130, Supplement 1, p. 1-32 32 p., 109857.

Research output: Contribution to journalArticle

Open Access
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2019

A comparison of flocked nylon swabs and non-flocked rayon swabs for detection of respiratory bacteria in nasopharyngeal carriage in Australian Indigenous children

Wigger, C., Morris, P. S., Stevens, M., Smith-Vaughan, H., Hare, K., Beissbarth, J. & Leach, A. J., 1 Feb 2019, In : Journal of Microbiological Methods. 157, p. 47-49 3 p.

Research output: Contribution to journalArticle

Open Access
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7 Downloads (Pure)
Open Access
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26 Downloads (Pure)

Povidone-iodine ear wash and oral cotrimoxazole for chronic suppurative otitis media in Australian aboriginal children: Study protocol for factorial design randomised controlled trial

Wigger, C., Leach, A. J., Beissbarth, J., Oguoma, V., Lennox, R., Nelson, S., Patel, H., Chatfield, M., Currie, K., Coates, H., Edwards, K., Smith-Vaughan, H., Hare, K., Torzillo, P., Tong, S. & Morris, P., 27 Jul 2019, In : BMC Pharmacology and Toxicology. 20, p. 1-6 6 p., 46.

Research output: Contribution to journalArticle

Open Access
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Preventative and medical treatment of ear disease in remote or resource-constrained environments

Brophy-Williams, S., Jarosz, K., Sommer, J., Leach, A. J. & Morris, P. S., Jan 2019, In : Journal of Laryngology and Otology. 133, Special Issue 1, p. 59-72 14 p.

Research output: Contribution to journalArticle

Open Access
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The ORVAC trial protocol: a phase IV, double-blind, randomised, placebo-controlled clinical trial of a third scheduled dose of Rotarix rotavirus vaccine in Australian Indigenous infants to improve protection against gastroenteritis

Middleton, B. F., Jones, M. A., Waddington, C. S., Danchin, M., McCallum, C., Gallagher, S., Leach, A. J., Andrews, R., Kirkwood, C., Cunliffe, N., Carapetis, J., Marsh, J. A. & Snelling, T., 14 Nov 2019, In : BMJ Open. 9, 11, p. 1-9 9 p., e032549.

Research output: Contribution to journalArticle

Open Access
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4 Downloads (Pure)
Open Access
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Open Access
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2018

Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children

Smith-Vaughan, H., Binks, M., Beissbarth, J., Chang, A., Mccallum, G., Mackay, I. M., Morris, P., Marsh, R., Torzillo, P. J., Wurzel, D. F., Grimwood, K., Nosworthy, E., Gaydon, J. E., Leach, A., Machunter, B., Chatfield, M., Sloots, T. P. & Cheng, A. C., 2018, In : European Journal of Clinical Microbiology and Infectious Diseases. 37, 9, p. 1785–1794 10 p.

Research output: Contribution to journalArticle

How low can we go? The implications of low bacterial load in respiratory microbiota studies

Marsh, R., Nelson, M. T., Pope, C., Leach, A., Hoffman, L., Chang, A. & Smith-Vaughan, H., 5 Jul 2018, In : Pneumonia. 10, p. 1-9 9 p., 7.

Research output: Contribution to journalReview article

Open Access
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9 Downloads (Pure)
Open Access
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2 Downloads (Pure)
2017

Culture of non-typeable Haemophilus influenzae from the nasopharynx: Not all media are equal

Harris, T. M., Rumaseb, A., Beissbarth, J., Barzi, F., Leach, A. J. & Smith-Vaughan, H. C., Jun 2017, In : Journal of Microbiological Methods. 137, p. 3-5 3 p.

Research output: Contribution to journalComment/debate

Ear, nose and throat surgery: All you need to know about the surgical approach to the management of middle-ear effusions in Australian Indigenous and non-Indigenous children

Kong, K., Lannigan, F. J., Morris, P. S., Leach, A. J. & O'Leary, S. J., Nov 2017, In : Journal of Paediatrics and Child Health. 53, 11, p. 1060-1064 5 p.

Research output: Contribution to journalReview article

Effect of a price discount and consumer education strategy on food and beverage purchases in remote Indigenous Australia: a stepped-wedge randomised controlled trial

Brimblecombe, J., Ferguson, M., Chatfield, M. D., Liberato, S. C., Gunther, A., Ball, K., Moodie, M., Miles, E., Magnus, A., Mhurchu, C. N., Leach, A. J., Bailie, R. & SHOP@RIC research collaborative, 1 Feb 2017, In : The Lancet Public Health. 2, 2, p. e82-e95 14 p.

Research output: Contribution to journalArticle

Open Access
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Microbiology of otitis media in Indigenous Australian children: review

Jervis-Brady, J., Duguid, A., Carney, A. S. B. & Leach, A., 2017, In : Journal of Laryngology and Otology. 131, S2, p. S2-S11 10 p.

Research output: Contribution to journalReview article

Predictors of pneumococcal carriage and the effect of the 13-valent pneumococcal conjugate vaccination in the Western Australian Aboriginal population

Collins, D., Hoskins, A., Snelling, T., Senasinghe, K., Bowman, J., Stemberger, N., Leach, A. & Lehmann, D., 2017, In : Pneumonia. 9, p. 1-11 11 p., 14.

Research output: Contribution to journalArticle

Open Access
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Propensity of pneumococcal carriage serotypes to infect the lower airways of children with chronic endobronchial infections

Hare, K. M., Smith-Vaughan, H. C., Chang, A. B., Pizzutto, S., Petsky, H. L., McCallum, G. B. & Leach, A. J., 1 Feb 2017, In : Vaccine. 35, 5, p. 747-756 10 p.

Research output: Contribution to journalArticle

Repeat pneumococcal polysaccharide vaccination does not impair functional immune responses among Indigenous Australians

Licciardi, P. V., Hoe, E., Toh, Z. Q., Balloch, A., Moberley, S., Binks, P., Marimla, R., Leach, A., Skull, S., MULHOLLAND, E. K. & Andrews, R., Oct 2017, In : Clinical and Translational Immunology. 6, 10, p. 1-4 4 p., e158.

Research output: Contribution to journalArticle

Open Access
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Repeat pneumococcal polysaccharide vaccine in Indigenous Australian adults is associated with decreased immune responsiveness

Moberley, S., Licciardi, P. V., Balloch, A., Andrews, R., Leach, A. J., Kirkwood, M., Binks, P., MULHOLLAND, E. K., Carapetis, J., Tang, M. L. K. & Skull, S., 19 May 2017, In : Vaccine. 35, 22, p. 2908-2915 8 p.

Research output: Contribution to journalArticle

Open Access
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Streptococcus pneumoniae and chronic endobronchial infections in childhood

Hare, K., Leach, A., Smith-Vaughan, H., Chang, A. & Grimwood, K., Dec 2017, In : Pediatric Pulmonology. 52, 12, p. 1532-1545 14 p.

Research output: Contribution to journalArticle

2016

Aboriginal and non-Aboriginal children in Western Australia carry different serotypes of pneumococci with different antimicrobial susceptibility profiles

Dunne, E., Carville, K., Riley, T., Bowman, J., Leach, A., Cripps, A., Murphy, D., Jacoby, P. & Lehmann, D., 2016, In : Pneumonia. 8, 15, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
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15 Downloads (Pure)

A multi-centre open-label randomised noninferiority trial comparing watchful waiting to antibiotic treatment for acute otitis media without perforation in low-risk urban Aboriginal and Torres Strait Islander children (the WATCH trial): Study protocol for a randomised controlled trial

Abbott, P., Gunasekera, H., Leach, A. J., Askew, D., Walsh, R., Kong, K., Girosi, F., Bond, C., Morris, P., Lujic, S., Hu, W., Usherwood, T., Tyson, S., Spurling, G., Douglas, M., Schubert, K., Chapman, S., Siddiqui, N., Murray, R., Rabbitt, K. & 4 others, Porykali, B., Woodall, C., Newman, T. & Reath, J., 2016, In : Trials. 17, 1, p. 1-10 10 p., 119.

Research output: Contribution to journalArticle

Open Access
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4 Downloads (Pure)
Open Access

Geographic consistency in dominant, non-typeable Haemophilus influenzae genotypes colonising four distinct Australian paediatric groups: a cohort study

Smith-Vaughan, H., Beissbarth, J., Bowman, J., Hare, K., PRICE, E., Pickering, J., Lehmann, D., Chang, A., Morris, P., Marsh, R. & Leach, A., 2016, In : Pneumonia. 8, 13, p. 1-6 6 p.

Research output: Contribution to journalArticle

Open Access
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3 Downloads (Pure)

Limited impact of neonatal or early infant schedules of 7-valent pneumococcal conjugate vaccination on nasopharyngeal carriage of Streptococcus pneumoniae in Papua New Guinean children: A randomized controlled trial

Aho, C., Michael, A., Yoannes, M., Greenhill, A., Jacoby, P., Reeder, J. R., Pomat, W., Saleu, G., Namuigi, P., Phuanukoonnon, S., Smith-Vaughan, H., Leach, A. J., Richmond, P. & Lehmann, D., 1 Dec 2016, In : Vaccine Reports. 6, p. 36-43 8 p.

Research output: Contribution to journalArticle

Open Access
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Safety and immunogenicity of RTS,S/AS01 malaria vaccine in infants and children with WHO stage 1 or 2 HIV disease: a randomised, double-blind, controlled trial

Otieno, L., Oneko, M., Otieno, W., Abuodha, J., Owino, E., Odero, C., Mendoza, Y. G., Andagalu, B., Awino, N., Ivinson, K., Heerwegh, D., Otsyula, N., Oziemkowska, M., Usuf, E. A., Otieno, A., Otieno, K., Leboulleux, D., Leach, A., Oyieko, J., Slutsker, L. & 7 others, Lievens, M., Cowden, J., Lapierre, D., Kariuki, S., Ogutu, B., Vekemans, J. & Hamel, M. J., 1 Oct 2016, In : Lancet Infectious Diseases. 16, 10, p. 1134-1144 11 p.

Research output: Contribution to journalArticle

Seven-year efficacy of RTS, S/AS01 malaria vaccine among young african children

Olotu, A., Fegan, G., Wambua, J., Nyangweso, G., Leach, A., Lievens, M., Kaslow, D. C., Njuguna, P., Marsh, K. & Bejon, P., 30 Jun 2016, In : New England Journal of Medicine. 374, 26, p. 2519-2529 11 p.

Research output: Contribution to journalArticle

Open Access
Open Access
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2015

Nasopharyngeal carriage and macrolide resistance in Indigenous children with bronchiectasis randomized to long-term azithromycin or placebo

Hare, K., Grimwood, K., Chang, A., Chatfield, M., Valery, P., Leach, A., Smith-Vaughan, H., Morris, P., Byrnes, C., Torzillo, P. & CHENG, A., Nov 2015, In : European Journal of Clinical Microbiology and Infectious Diseases. 34, 11, p. 2275-2285 11 p.

Research output: Contribution to journalArticle

Pneumococcal conjugate vaccines PREVenar13 and SynflorIX in sequence or alone in high-risk indigenous infants (PREV-IX_COMBO): protocol of a randomised controlled trial

Leach, A., MULHOLLAND, E. K., Santosham, M., Torzillo, P., Brown, N., McIntyre, P., Smith-Vaughan, H., Skull, S., Balloch, A., Andrews, R., Carapetis, J., McDonnell, J., Krause, V. & Morris, P., Jan 2015, In : BMJ Open. 5, 1, p. 1-10 10 p., e007247.

Research output: Contribution to journalComment/debate

Open Access
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PneuMum: Impact from a randomised controlled trial of maternal 23-valent pneumococcal polysaccharide vaccination on middle ear disease amongst Indigenous infants, Northern Territory, Australia

Binks, M. J., Moberley, S. A., Balloch, A., Leach, A. J., Nelson, S., Hare, K. M., Wilson, C., Morris, P. S., Nelson, J., Chatfield, M. D., Tang, M. L. K., Torzillo, P., Carapetis, J. R., Mulholland, E. K. & Andrews, R. M., 27 Nov 2015, In : Vaccine. 33, 48, p. 6579-6587 9 p.

Research output: Contribution to journalArticle

Open Access
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Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine

Leach, A. J., Wigger, C., Hare, K., Hampton, V., Beissbarth, J., Andrews, R., Chatfield, M., Smith-Vaughan, H. & Morris, P. S., 19 Oct 2015, In : BMC Pediatrics. 15, p. 1-13 13 p., 162.

Research output: Contribution to journalArticle

Open Access
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The microbiome of otitis media with effusion in Indigenous Australian children

Jervis-Brady, J., Rogers, G., Morris, P., Smith-Vaughan, H., Nosworthy, E., Leong, L. E. X., Smith, R. J., Weyriche, L. S., De Haan, J., Carney, S., Leach, A., O'Leary, S. & Marsh, R., Sep 2015, In : International Journal of Pediatric Otorhinolaryngology. 79, 9, p. 1548-1555 8 p.

Research output: Contribution to journalArticle

2014

Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae

Smith-Vaughan, H. C., Chang, A. B., Sarovich, D. S., Marsh, R. L., Grimwood, K., Leach, A. J., Morris, P. S. & Price, E. P., Feb 2014, In : Clinical and Vaccine Immunology. 21, 2, p. 250-252 3 p.

Research output: Contribution to journalArticle

Open Access

Can mobile phone multimedia messages and text messages improve clinic attendance for Aboriginal children with chronic otitis media? A randomised controlled trial

Phillips, J., Wigger, C., Beissbarth, J., Mccallum, G., Leach, A. & Morris, P., May 2014, In : Journal of Paediatrics and Child Health. 50, 5, p. 362-367 6 p.

Research output: Contribution to journalArticle

Comparison of Anti-pneumococcal Antibodies in Cord Blood From Australian Indigenous and Gambian Neonates and the Implications for Otitis Media

Balloch, A., Licciardi, P., Kemp, A., Leach, A., MULHOLLAND, E. K. & Tang, M., Apr 2014, In : Pediatric Infectious Disease Journal. 33, 4, p. E116-E120 5 p.

Research output: Contribution to journalArticle

Diversity of Nontypeable Haemophilus influenzae strains colonizing Australian Aboriginal and non-Aboriginal children

Pickering, J., Smith-Vaughan, H., Beissbarth, J., Bowman, J., Wiertsema, S. P., Riley, T., Leach, A., Richmond, P. C., Lehmann, D. & Kirkham, L-A. S., May 2014, In : Journal of Clinical Microbiology. 52, 5, p. 1352-1357 6 p.

Research output: Contribution to journalArticle

Open Access

Otitis media in children vaccinated during consecutive 7-valent or 10-valent pneumococcal conjugate vaccination schedules

Leach, A., Wigger, C., Andrews, R., Chatfield, M., Smith-Vaughan, H. & Morris, P., 2014, In : BMC Pediatrics. 14, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Open Access
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2013
Open Access
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Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure

Olotu, A., Fegan, G., Wambua, J., Nyangweso, G., Awuondo, K., Leach, A., Lievens, M., Leboulleux, D., Njuguna, P., Peshu, N., Marsh, K. & Bejon, P., 2013, In : New England Journal of Medicine. 368, 12, p. 1111-1120 10 p.

Research output: Contribution to journalArticle

Open Access

High Nasopharyngeal Carriage of Non-Vaccine Serotypes in Western Australian Aboriginal People Following 10 Years of Pneumococcal Conjugate Vaccination

Collins, D., Hoskins, A., Bowman, J., Jones, J., Stemberger, N., Richmond, P. C., Leach, A. & Lehmann, D., 2013, In : PLoS One. 8, 12, p. 1-9 9 p., e82280.

Research output: Contribution to journalArticle

Open Access
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Impact of swimming on chronic suppurative otitis media in Aboriginal children: a randomised controlled trial

Stephen, A., Leach, A. & Morris, P., 2013, In : Medical Journal of Australia. 199, 1, p. 51-55 5 p.

Research output: Contribution to journalArticle

Longitudinal Nasopharyngeal Carriage and Antibiotic Resistance of Respiratory Bacteria in Indigenous Australian and Alaska Native Children with Bronchiectasis

Hare, K., Singleton, R., Grimwood, K., Valery, P., Cheng, A., Morris, P., Leach, A., Smith-Vaughan, H., Chatfield, M., Redding, G., Reasonover, A., Mccallum, G., Chikoyak, L., McDonald, M., Brown, N., Torzillo, P. & Chang, A., 2013, In : PLoS One. 8, 8, p. 1-9 9 p., e70478.

Research output: Contribution to journalArticle

Open Access
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Panel 6: Vaccines

Pelton, S. I., Pettigrew, M., Barenkamp, S. J., Godfroid, F., Grijalva, C. G., Leach, A., Patel, J., Murphy, T. F., Selak, S. & Bakaletz, L. O., Apr 2013, In : Otolaryngology - Head and Neck Surgery. 148, 4 SUPPL., p. E90-E101 12 p.

Research output: Contribution to journalArticle

Open Access