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2019

A comparison of flocked nylon swabs and non-flocked rayon swabs for detection of respiratory bacteria in nasopharyngeal carriage in Australian Indigenous children

Wigger, C., Morris, P. S., Stevens, M., Smith-Vaughan, H., Hare, K., Beissbarth, J. & Leach, A. J., 1 Feb 2019, In : Journal of Microbiological Methods. 157, p. 47-49 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Nylons
Bacteria
Haemophilus influenzae
Streptococcus pneumoniae
Moraxella (Branhamella) catarrhalis
7 Downloads (Pure)

Hearing and justice: The link between hearing impairment in early childhood and youth offending in Aboriginal children living in remote communities of the Northern Territory, Australia

He, V. Y., Su, J-Y., Guthridge, S., Malvaso, C., Howard, D. R., Williams, T. & Leach, A., 30 Oct 2019, In : Health and Justice. 7, p. 1-12 12 p., 16.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Northern Territory
hearing impairment
Social Justice
Hearing Loss
Hearing

Povidone-iodine ear wash and oral cotrimoxazole for chronic suppurative otitis media in Australian aboriginal children: Study protocol for factorial design randomised controlled trial

Wigger, C., Leach, A. J., Beissbarth, J., Oguoma, V., Lennox, R., Nelson, S., Patel, H., Chatfield, M., Currie, K., Coates, H., Edwards, K., Smith-Vaughan, H., Hare, K., Torzillo, P., Tong, S. & Morris, P., 27 Jul 2019, In : BMC Pharmacology and Toxicology. 20, p. 1-6 6 p., 46.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Suppurative Otitis Media
Povidone-Iodine
Sulfamethoxazole Drug Combination Trimethoprim
Ear
Randomized Controlled Trials

Preventative and medical treatment of ear disease in remote or resource-constrained environments

Brophy-Williams, S., Jarosz, K., Sommer, J., Leach, A. J. & Morris, P. S., Jan 2019, In : Journal of Laryngology and Otology. 133, Special Issue 1, p. 59-72 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Ear Diseases
Otitis Media
Suppurative Otitis Media
Ear
Hearing Loss

The impact of hearing impairment on Aboriginal children’s school attendance in remote Northern Territory: a data linkage study

Su, J. Y., He, V. Y., Guthridge, S., Howard, D., Leach, A. & Silburn, S., 30 Oct 2019, In : Australian and New Zealand Journal of Public Health. p. 1-7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Northern Territory
Information Storage and Retrieval
Hearing Loss
Hearing
Unilateral Hearing Loss
1 Downloads (Pure)

The ORVAC trial protocol: a phase IV, double-blind, randomised, placebo-controlled clinical trial of a third scheduled dose of Rotarix rotavirus vaccine in Australian Indigenous infants to improve protection against gastroenteritis

Middleton, B. F., Jones, M. A., Waddington, C. S., Danchin, M., McCallum, C., Gallagher, S., Leach, A. J., Andrews, R., Kirkwood, C., Cunliffe, N., Carapetis, J., Marsh, J. A. & Snelling, T., 14 Nov 2019, In : BMJ Open. 9, 11, p. 1-9 9 p., e032549.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Rotavirus Vaccines
Rotavirus
Gastroenteritis
Clinical Protocols
Randomized Controlled Trials
Open Access
Respiratory Syncytial Viruses
infant
Population
community
Viruses
Haemophilus influenzae
Conjugate Vaccines
Population Groups
Northern Territory
Pediatrics
2018

Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children

Smith-Vaughan, H., Binks, M., Beissbarth, J., Chang, A., Mccallum, G., Mackay, I. M., Morris, P., Marsh, R., Torzillo, P. J., Wurzel, D. F., Grimwood, K., Nosworthy, E., Gaydon, J. E., Leach, A., Machunter, B., Chatfield, M., Sloots, T. P. & Cheng, A. C., 2018, In : European Journal of Clinical Microbiology and Infectious Diseases. 37, 9, p. 1785–1794 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Nasopharynx
Respiratory Tract Infections
Viruses
Bacteria
Human Adenoviruses
9 Downloads (Pure)

How low can we go? The implications of low bacterial load in respiratory microbiota studies

Marsh, R., Nelson, M. T., Pope, C., Leach, A., Hoffman, L., Chang, A. & Smith-Vaughan, H., 5 Jul 2018, In : Pneumonia. 10, p. 1-9 9 p., 7.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
File
Bacterial Load
Microbiota
Bacteria
Lung
DNA
2 Downloads (Pure)
Open Access
File
Haemophilus influenzae
Polymerase Chain Reaction
Pharynx
Nose
Haemophilus
2017

Culture of non-typeable Haemophilus influenzae from the nasopharynx: Not all media are equal

Harris, T. M., Rumaseb, A., Beissbarth, J., Barzi, F., Leach, A. J. & Smith-Vaughan, H. C., Jun 2017, In : Journal of Microbiological Methods. 137, p. 3-5 3 p.

Research output: Contribution to journalComment/debateResearchpeer-review

Nasopharynx
Haemophilus influenzae
Agar
Bacitracin
Clindamycin

Ear, nose and throat surgery: All you need to know about the surgical approach to the management of middle-ear effusions in Australian Indigenous and non-Indigenous children

Kong, K., Lannigan, F. J., Morris, P. S., Leach, A. J. & O'Leary, S. J., Nov 2017, In : Journal of Paediatrics and Child Health. 53, 11, p. 1060-1064 5 p.

Research output: Contribution to journalReview articleResearchpeer-review

Otitis Media with Effusion
Pharynx
Nose
Ear
Otitis Media
3 Downloads (Pure)

Effect of a price discount and consumer education strategy on food and beverage purchases in remote Indigenous Australia: a stepped-wedge randomised controlled trial

Brimblecombe, J., Ferguson, M., Chatfield, M. D., Liberato, S. C., Gunther, A., Ball, K., Moodie, M., Miles, E., Magnus, A., Mhurchu, C. N., Leach, A. J., Bailie, R. & SHOP@RIC research collaborative, 1 Feb 2017, In : The Lancet Public Health. 2, 2, p. e82-e95 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Food and Beverages
Randomized Controlled Trials
Vegetables
Fruit
Education

Microbiology of otitis media in Indigenous Australian children: review

Jervis-Brady, J., Duguid, A., Carney, A. S. B. & Leach, A., 2017, In : Journal of Laryngology and Otology. 131, S2, p. S2-S11 10 p.

Research output: Contribution to journalReview articleResearchpeer-review

Nasopharynx
Otitis Media
Middle Ear
Microbiology
Moraxella (Branhamella) catarrhalis
2 Downloads (Pure)

Predictors of pneumococcal carriage and the effect of the 13-valent pneumococcal conjugate vaccination in the Western Australian Aboriginal population

Collins, D., Hoskins, A., Snelling, T., Senasinghe, K., Bowman, J., Stemberger, N., Leach, A. & Lehmann, D., 2017, In : Pneumonia. 9, p. 1-11 11 p., 14.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Vaccination
Odds Ratio
Population
Confidence Intervals
Crowding

Propensity of pneumococcal carriage serotypes to infect the lower airways of children with chronic endobronchial infections

Hare, K. M., Smith-Vaughan, H. C., Chang, A. B., Pizzutto, S., Petsky, H. L., McCallum, G. B. & Leach, A. J., 1 Feb 2017, In : Vaccine. 35, 5, p. 747-756 10 p.

Research output: Contribution to journalArticleResearchpeer-review

serotypes
Infection
infection
Bronchoalveolar Lavage
odds ratio
3 Downloads (Pure)

Repeat pneumococcal polysaccharide vaccination does not impair functional immune responses among Indigenous Australians

Licciardi, P. V., Hoe, E., Toh, Z. Q., Balloch, A., Moberley, S., Binks, P., Marimla, R., Leach, A., Skull, S., MULHOLLAND, E. K. & Andrews, R., Oct 2017, In : Clinical and Translational Immunology. 6, 10, p. 1-4 4 p., e158.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Polysaccharides
Pneumococcal Vaccines
Vaccination
Northern Territory
Appointments and Schedules

Repeat pneumococcal polysaccharide vaccine in Indigenous Australian adults is associated with decreased immune responsiveness

Moberley, S., Licciardi, P. V., Balloch, A., Andrews, R., Leach, A. J., Kirkwood, M., Binks, P., MULHOLLAND, E. K., Carapetis, J., Tang, M. L. K. & Skull, S., 19 May 2017, In : Vaccine. 35, 22, p. 2908-2915 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Pneumococcal Vaccines
polysaccharides
vaccines
dosage
serotypes

Streptococcus pneumoniae and chronic endobronchial infections in childhood

Hare, K., Leach, A., Smith-Vaughan, H., Chang, A. & Grimwood, K., Dec 2017, In : Pediatric Pulmonology. 52, 12, p. 1532-1545 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Streptococcus pneumoniae
Bronchiectasis
Lung Diseases
Infection
Bronchitis
2016
10 Downloads (Pure)

Aboriginal and non-Aboriginal children in Western Australia carry different serotypes of pneumococci with different antimicrobial susceptibility profiles

Dunne, E., Carville, K., Riley, T., Bowman, J., Leach, A., Cripps, A., Murphy, D., Jacoby, P. & Lehmann, D., 2016, In : Pneumonia. 8, 15, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Western Australia
Streptococcus pneumoniae
Conjugate Vaccines
Pneumococcal Vaccines
Disk Diffusion Antimicrobial Tests
4 Downloads (Pure)

A multi-centre open-label randomised noninferiority trial comparing watchful waiting to antibiotic treatment for acute otitis media without perforation in low-risk urban Aboriginal and Torres Strait Islander children (the WATCH trial): Study protocol for a randomised controlled trial

Abbott, P., Gunasekera, H., Leach, A. J., Askew, D., Walsh, R., Kong, K., Girosi, F., Bond, C., Morris, P., Lujic, S., Hu, W., Usherwood, T., Tyson, S., Spurling, G., Douglas, M., Schubert, K., Chapman, S., Siddiqui, N., Murray, R., Rabbitt, K. & 4 others, Porykali, B., Woodall, C., Newman, T. & Reath, J., 2016, In : Trials. 17, 1, p. 1-10 10 p., 119.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Watchful Waiting
Otitis Media
Clinical Protocols
Randomized Controlled Trials
Anti-Bacterial Agents
Open Access
Northern Territory
Conjugate Vaccines
Otitis Media
Middle Ear
Microbiology
3 Downloads (Pure)

Geographic consistency in dominant, non-typeable Haemophilus influenzae genotypes colonising four distinct Australian paediatric groups: a cohort study

Smith-Vaughan, H., Beissbarth, J., Bowman, J., Hare, K., PRICE, E., Pickering, J., Lehmann, D., Chang, A., Morris, P., Marsh, R. & Leach, A., 2016, In : Pneumonia. 8, 13, p. 1-6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Haemophilus influenzae
Cohort Studies
Genotype
Pediatrics
Ribotyping

Limited impact of neonatal or early infant schedules of 7-valent pneumococcal conjugate vaccination on nasopharyngeal carriage of Streptococcus pneumoniae in Papua New Guinean children: A randomized controlled trial

Aho, C., Michael, A., Yoannes, M., Greenhill, A., Jacoby, P., Reeder, J. R., Pomat, W., Saleu, G., Namuigi, P., Phuanukoonnon, S., Smith-Vaughan, H., Leach, A. J., Richmond, P. & Lehmann, D., 1 Dec 2016, In : Vaccine Reports. 6, p. 36-43 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Pneumococcal Vaccines
Conjugate Vaccines
Streptococcus pneumoniae
Appointments and Schedules
Vaccination

Safety and immunogenicity of RTS,S/AS01 malaria vaccine in infants and children with WHO stage 1 or 2 HIV disease: a randomised, double-blind, controlled trial

Otieno, L., Oneko, M., Otieno, W., Abuodha, J., Owino, E., Odero, C., Mendoza, Y. G., Andagalu, B., Awino, N., Ivinson, K., Heerwegh, D., Otsyula, N., Oziemkowska, M., Usuf, E. A., Otieno, A., Otieno, K., Leboulleux, D., Leach, A., Oyieko, J., Slutsker, L. & 7 others, Lievens, M., Cowden, J., Lapierre, D., Kariuki, S., Ogutu, B., Vekemans, J. & Hamel, M. J., 1 Oct 2016, In : Lancet Infectious Diseases. 16, 10, p. 1134-1144 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Rabies Vaccines
Malaria Vaccines
HIV-2
HIV-1
Safety

Seven-year efficacy of RTS, S/AS01 malaria vaccine among young african children

Olotu, A., Fegan, G., Wambua, J., Nyangweso, G., Leach, A., Lievens, M., Kaslow, D. C., Njuguna, P., Marsh, K. & Bejon, P., 30 Jun 2016, In : New England Journal of Medicine. 374, 26, p. 2519-2529 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Malaria Vaccines
Malaria
Confidence Intervals
Parasites
Vaccination

The short-term impact of each primary dose of pneumococcal conjugate vaccine on nasopharyngeal carriage: Systematic review and meta-analyses of randomised controlled trials

Thomas Rodger, N., Leach, A. & Morris, P., 2016, In : Vaccine. 34, 6, p. 703-713 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Conjugate Vaccines
Pneumococcal Vaccines
systematic review
Meta-Analysis
Randomized Controlled Trials
2015

Haemophilus influenzae isolates survive for up to 20years at -70°C in skim milk tryptone glucose glycerol broth (STGGB) if thawing is avoided during re-culture

Hare, K. M., Smith-Vaughan, H. C., Leach, A. J. & Beissbarth, J., 1 Dec 2015, In : Journal of Microbiological Methods. 119, p. 132-133 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Haemophilus influenzae
Glycerol
Milk
Glucose
Moraxella (Branhamella) catarrhalis

Nasopharyngeal carriage and macrolide resistance in Indigenous children with bronchiectasis randomized to long-term azithromycin or placebo

Hare, K., Grimwood, K., Chang, A., Chatfield, M., Valery, P., Leach, A., Smith-Vaughan, H., Morris, P., Byrnes, C., Torzillo, P. & CHENG, A., Nov 2015, In : European Journal of Clinical Microbiology and Infectious Diseases. 34, 11, p. 2275-2285 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Azithromycin
Bronchiectasis
Macrolides
Placebos
Streptococcus pneumoniae
11 Downloads (Pure)

Pneumococcal conjugate vaccines PREVenar13 and SynflorIX in sequence or alone in high-risk indigenous infants (PREV-IX_COMBO): protocol of a randomised controlled trial

Leach, A., MULHOLLAND, E. K., Santosham, M., Torzillo, P., Brown, N., McIntyre, P., Smith-Vaughan, H., Skull, S., Balloch, A., Andrews, R., Carapetis, J., McDonnell, J., Krause, V. & Morris, P., Jan 2015, In : BMJ Open. 5, 1, p. 1-10 10 p., e007247.

Research output: Contribution to journalComment/debateResearch

Open Access
File
Conjugate Vaccines
Pneumococcal Vaccines
Otitis Media
Randomized Controlled Trials
Northern Territory
13 Downloads (Pure)

PneuMum: Impact from a randomised controlled trial of maternal 23-valent pneumococcal polysaccharide vaccination on middle ear disease amongst Indigenous infants, Northern Territory, Australia

Binks, M. J., Moberley, S. A., Balloch, A., Leach, A. J., Nelson, S., Hare, K. M., Wilson, C., Morris, P. S., Nelson, J., Chatfield, M. D., Tang, M. L. K., Torzillo, P., Carapetis, J. R., Mulholland, E. K. & Andrews, R. M., 27 Nov 2015, In : Vaccine. 33, 48, p. 6579-6587 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
ear diseases
Northern Territory
Ear Diseases
Middle Ear
Polysaccharides
12 Downloads (Pure)

Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine

Leach, A. J., Wigger, C., Hare, K., Hampton, V., Beissbarth, J., Andrews, R., Chatfield, M., Smith-Vaughan, H. & Morris, P. S., 19 Oct 2015, In : BMC Pediatrics. 15, p. 1-13 13 p., 162.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Conjugate Vaccines
Haemophilus influenzae
Middle Ear
Streptococcus pneumoniae
Infection

The microbiome of otitis media with effusion in Indigenous Australian children

Jervis-Brady, J., Rogers, G., Morris, P., Smith-Vaughan, H., Nosworthy, E., Leong, L. E. X., Smith, R. J., Weyriche, L. S., De Haan, J., Carney, S., Leach, A., O'Leary, S. & Marsh, R., Sep 2015, In : International Journal of Pediatric Otorhinolaryngology. 79, 9, p. 1548-1555 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Otitis Media with Effusion
Microbiota
Middle Ear
Adenoids
Haemophilus influenzae