A 5- versus 3-day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomised controlled trial

Anne Chang, R CLARK, Theo P Sloots, D Stone, Helen Petsky, D THEARLE, A Champion, C Wheeler, Jason Acworth

    Research output: Contribution to journalArticle

    Abstract

    Objective: To determine whether a 5-day course of oral prednisolone is superior to a 3-day course in reducing the 2-week morbidity of children with asthma exacerbations who are not hospitalised. Design, setting and participants: Double-blind randomised controlled trial of as outcomes following a 5-day course of oral prednisolone (1 mg/ kg) compared with 3-day course of prednisolone plus placebo for 2 days. Participants were children aged 2-15 years who presented to the emergency departments of three Queensland hospitals between March 2004 and February 2007 with an acute exacerbation of asthma, but were not hospitalised. Sample size was defined a priori for a study power of 90%. Main outcome measures: Difference in proportion of children who were symptom-free at Day 7, as measured by intention-to-treat (ITT) and per-protocol analysis; quality of life (QOL) on Days 7 and 14. Results: 201 children were enrolled, and there was an 82% completion rate. There was no difference between groups in the proportion of children who were symptom-free (observed difference, 0.04 [95% Cl, -0.09 to 0.18] by ITT analysis; 0.04 [95% Cl, -0.17 to 0.09] by per-protocol analysis). There was also no difference between groups in QOL (P= 0.42). The difference between groups for the primary outcome was within the equivalence range calculated post priori. Conclusion: A 5-day course of oral prednisolone confers no advantage over a 3-day course for children with asthma exacerbations who are not hospitalised.
    Original languageEnglish
    Pages (from-to)306-310
    Number of pages5
    JournalMedical Journal of Australia
    Volume189
    Issue number6
    Publication statusPublished - 2008

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    Chang, A., CLARK, R., Sloots, T. P., Stone, D., Petsky, H., THEARLE, D., Champion, A., Wheeler, C., & Acworth, J. (2008). A 5- versus 3-day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomised controlled trial. Medical Journal of Australia, 189(6), 306-310.