A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: The Staphylococcus aureus Network Adaptive Platform trial

Robert K. Mahar; Anna McGlothlin; Michael Dymock; Todd C. Lee; Roger J. Lewis; Thomas Lumley; Jocelyn Mora; David J. Price; Benjamin R. Saville; Tom Snelling; Rebecca Turner; Steven A. Webb; Joshua S. Davis; Steven Y. C Tong; Julie A. Marsh

doi:10.1186/s13063-023-07718-x

A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: The Staphylococcus aureus Network Adaptive Platform trial

Robert K. Mahar, Anna McGlothlin, Michael Dymock, Todd C. Lee, Roger J. Lewis, Thomas Lumley, Jocelyn Mora, David J. Price, Benjamin R. Saville, Tom Snelling, Rebecca Turner, Steven A. Webb, Joshua S. Davis, Steven Y. C Tong, Julie A. Marsh

Global and Tropical Health

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Abstract

The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus bloodstream infection, a globally common and severe infectious disease, is treated. In a world first, the SNAP trial will simultaneously investigate the effects of multiple intervention modalities within multiple groups of participants with different forms of S. aureus bloodstream infection. Here, we formalise the trial structure, modelling approach, and decision rules that will be used for the SNAP trial. By summarising the statistical principles governing the design, our hope is that the SNAP trial will serve as an adaptable template that can be used to improve comparative effectiveness research efficiency in other disease areas. Trial registration NCT05137119 . Registered on 30 November 2021.

Original language	English
Article number	795
Pages (from-to)	1-15
Number of pages	15
Journal	Trials
Volume	24
Issue number	1
DOIs	https://doi.org/10.1186/s13063-023-07718-x
Publication status	Published - Dec 2023

Bibliographical note

Funding Information:
This work is supported by the Australian National Health and Medical Research Council (NHMRC) (1184238, 2014900), the Medical Research Future Fund (2017301), the Canadian Institutes of Health Research (451092), the Health Research Council of New Zealand (20/344), the Athlae Lyon/Starship Foundation Trust (ASF2144_WEBB), the National Medical Research Council (CTGIIT21nov-0002), and the United Kingdom National Institute for Health Research (NIHR133719). Rebecca Turner was supported by the UK Medical Research Council (Programme MC_UU_00004/07). This study/project is funded by the NIHR [NIHR133719]. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13063-023-07718-x

93152114-oaFinal published version, 1.98 MBLicence: CC BY

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Mahar, R. K., McGlothlin, A., Dymock, M., Lee, T. C., Lewis, R. J., Lumley, T., Mora, J., Price, D. J., Saville, B. R., Snelling, T., Turner, R., Webb, S. A., Davis, J. S., Tong, S. Y. C., & Marsh, J. A. (2023). A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: The Staphylococcus aureus Network Adaptive Platform trial. Trials, 24(1), 1-15. Article 795. https://doi.org/10.1186/s13063-023-07718-x

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title = "A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: The Staphylococcus aureus Network Adaptive Platform trial",

abstract = "The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus bloodstream infection, a globally common and severe infectious disease, is treated. In a world first, the SNAP trial will simultaneously investigate the effects of multiple intervention modalities within multiple groups of participants with different forms of S. aureus bloodstream infection. Here, we formalise the trial structure, modelling approach, and decision rules that will be used for the SNAP trial. By summarising the statistical principles governing the design, our hope is that the SNAP trial will serve as an adaptable template that can be used to improve comparative effectiveness research efficiency in other disease areas. Trial registration NCT05137119 . Registered on 30 November 2021.",

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author = "Mahar, {Robert K.} and Anna McGlothlin and Michael Dymock and Lee, {Todd C.} and Lewis, {Roger J.} and Thomas Lumley and Jocelyn Mora and Price, {David J.} and Saville, {Benjamin R.} and Tom Snelling and Rebecca Turner and Webb, {Steven A.} and Davis, {Joshua S.} and Tong, {Steven Y. C} and Marsh, {Julie A.}",

note = "Funding Information: This work is supported by the Australian National Health and Medical Research Council (NHMRC) (1184238, 2014900), the Medical Research Future Fund (2017301), the Canadian Institutes of Health Research (451092), the Health Research Council of New Zealand (20/344), the Athlae Lyon/Starship Foundation Trust (ASF2144_WEBB), the National Medical Research Council (CTGIIT21nov-0002), and the United Kingdom National Institute for Health Research (NIHR133719). Rebecca Turner was supported by the UK Medical Research Council (Programme MC_UU_00004/07). This study/project is funded by the NIHR [NIHR133719]. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. ",

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doi = "10.1186/s13063-023-07718-x",

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Mahar, RK, McGlothlin, A, Dymock, M, Lee, TC, Lewis, RJ, Lumley, T, Mora, J, Price, DJ, Saville, BR, Snelling, T, Turner, R, Webb, SA, Davis, JS, Tong, SYC & Marsh, JA 2023, 'A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: The Staphylococcus aureus Network Adaptive Platform trial', Trials, vol. 24, no. 1, 795, pp. 1-15. https://doi.org/10.1186/s13063-023-07718-x

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AU - McGlothlin, Anna

AU - Dymock, Michael

AU - Lee, Todd C.

AU - Lewis, Roger J.

AU - Lumley, Thomas

AU - Mora, Jocelyn

AU - Price, David J.

AU - Saville, Benjamin R.

AU - Snelling, Tom

AU - Turner, Rebecca

AU - Webb, Steven A.

AU - Davis, Joshua S.

AU - Tong, Steven Y. C

AU - Marsh, Julie A.

N1 - Funding Information: This work is supported by the Australian National Health and Medical Research Council (NHMRC) (1184238, 2014900), the Medical Research Future Fund (2017301), the Canadian Institutes of Health Research (451092), the Health Research Council of New Zealand (20/344), the Athlae Lyon/Starship Foundation Trust (ASF2144_WEBB), the National Medical Research Council (CTGIIT21nov-0002), and the United Kingdom National Institute for Health Research (NIHR133719). Rebecca Turner was supported by the UK Medical Research Council (Programme MC_UU_00004/07). This study/project is funded by the NIHR [NIHR133719]. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.

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KW - Randomised

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A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: The Staphylococcus aureus Network Adaptive Platform trial

Abstract

Bibliographical note

UN SDGs

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