TY - JOUR
T1 - A Clinical Investigation on the Theragnostic Effect of MicroRNA Biomarkers for Survival Outcome in Cervical Cancer
T2 - A PRISMA-P Compliant Protocol for Systematic Review and Comprehensive Meta-Analysis
AU - Shaw, Peter
AU - Senthilnathan, Raghul
AU - Sankar, Srivarshini
AU - Ilangovan, Ilamathi
AU - Muthukaliannan, Gothandam Kodiveri
AU - Baxi, Siddhartha
AU - Mani, Ravishankar Ram
AU - Rajagopal, Mogana
AU - Chinnappan, Sasikala
AU - Balaraman, Ashok Kumar
AU - Suresh, Deepa
AU - Krishnan, Sunil
AU - Gupta, Madanmohan
AU - Muthusamy, Thangavel
AU - Paranjothy, Chitraabaanu
AU - Jayaraj, Rama
N1 - Funding: Funded in part by the National Institutes of Health (NIH)/National Institute of Dental and Craniofacial Research (NIDCR) R01DE028105 grant to S.K. Peter Shaw was supported in part by the Jiangsu province, China, 100 Talent project fund (BX2020100) and Double Innovation grant, Jiangsu (JSSCR2021520). Funded in part by the UCSI PSIF Proj-2019-In-FPS-027 grant to Mogana Rajagopal.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3
Y1 - 2022/3
N2 - Background: The most often diagnosed malignancy in women worldwide is cancer of the cervix. It is also the most prevalent kind of gynecological cancer in women. This cancer originates in the opening of the cervix and spreads through sexual contact. Even though human papillomavirus (HPV) may not cause cancer immediately, it does develop over time as a result of the virus’s lengthy persistence to cause dysplastic changes overtime, particularly in high-risk kinds. The primary objective of this research is to see if miRNAs are dysregulated as a result of treatment resistance in cervical cancer (CC). The aim is to see if these microRNAs may be utilized as biomarkers for detecting chemoresistance in CC, particularly for clinical applications. Methods: The recommended protocol for comprehensive study and meta-analysis (PRISMA-P) standards will be utilized for the analysis and data interpretation. The bibliographic databases will be methodically searched using a combination of search keywords. Based on established inclusion and exclusion criteria, the acquired findings will be reviewed, and data retrieved from the selected scientific papers for systematic review. We will then construct a forest from the pooled Hazard ratio (HR) and 95% CI values, data obtained using the random-effects model. Discussion: The focus of this study is to identify the function of miRNAs as a chemoresistance regulator and determine if they have the potential scope to be considered as biomarkers for cervical cancer. Through this systematic review and meta-analysis, the goal is to collect, compare, and analyze the data pertaining to the role of miRNAs in cervical cancer, thereby, enabling us to understand the role they play in chemosensitivity.
AB - Background: The most often diagnosed malignancy in women worldwide is cancer of the cervix. It is also the most prevalent kind of gynecological cancer in women. This cancer originates in the opening of the cervix and spreads through sexual contact. Even though human papillomavirus (HPV) may not cause cancer immediately, it does develop over time as a result of the virus’s lengthy persistence to cause dysplastic changes overtime, particularly in high-risk kinds. The primary objective of this research is to see if miRNAs are dysregulated as a result of treatment resistance in cervical cancer (CC). The aim is to see if these microRNAs may be utilized as biomarkers for detecting chemoresistance in CC, particularly for clinical applications. Methods: The recommended protocol for comprehensive study and meta-analysis (PRISMA-P) standards will be utilized for the analysis and data interpretation. The bibliographic databases will be methodically searched using a combination of search keywords. Based on established inclusion and exclusion criteria, the acquired findings will be reviewed, and data retrieved from the selected scientific papers for systematic review. We will then construct a forest from the pooled Hazard ratio (HR) and 95% CI values, data obtained using the random-effects model. Discussion: The focus of this study is to identify the function of miRNAs as a chemoresistance regulator and determine if they have the potential scope to be considered as biomarkers for cervical cancer. Through this systematic review and meta-analysis, the goal is to collect, compare, and analyze the data pertaining to the role of miRNAs in cervical cancer, thereby, enabling us to understand the role they play in chemosensitivity.
KW - Biomarkers
KW - Cervical cancer
KW - Chemoresistance
KW - MiRNA
UR - http://www.scopus.com/inward/record.url?scp=85126450227&partnerID=8YFLogxK
U2 - 10.3390/genes13030463
DO - 10.3390/genes13030463
M3 - Article
C2 - 35328017
AN - SCOPUS:85126450227
VL - 13
SP - 1
EP - 11
JO - Genes
JF - Genes
SN - 2073-4425
IS - 3
M1 - 463
ER -