A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom

Geoffrey Isbister, M O'LEARY, M Miller, S BROWN, S Ramasamy, R James, Jennifer Schneider

    Research output: Contribution to journalArticle

    Abstract

    AIMS: There are no studies measuring antivenom concentrations following intramuscular administration. This study aimed to compare antivenom concentrations following intravenous and intramuscular administration of redback spider antivenom (RBSAV). METHODS: Twenty patients recruited to a controlled trial comparing intramuscular and intravenous administration of antivenom had serial blood samples collected at 30 min intervals for 2 h after the administration of one or two doses of antivenom. Antivenom concentration was measured using an enzyme immunoassay. RESULTS: Ten patients received intramuscular antivenom but antivenom could not be detected in serum after either one or two vials, at any time point. The median time of the final sample after commencement of antivenom treatment in these patients was 3.2 h (1.8-5 h). Ten patients received intravenous antivenom (three one vial and seven two or more vials) and antivenom was detected in all patients. CONCLUSIONS: RBS AV given by the intramuscular route is unlikely to be effective in the treatment of redback (widow) spider bite. � 2007 The Authors.
    Original languageEnglish
    Pages (from-to)139-143
    Number of pages5
    JournalBritish Journal of Clinical Pharmacology
    Volume65
    Issue number1
    Publication statusPublished - 2008

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    Isbister, G., O'LEARY, M., Miller, M., BROWN, S., Ramasamy, S., James, R., & Schneider, J. (2008). A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom. British Journal of Clinical Pharmacology, 65(1), 139-143.