A comparison of the potent in vitro antitumor activity of triphenyltin benzoates with that of related tin compounds

Carolyn J. Tranter, Susan J. Berners Price, Janelle Cutts, Peter G. Parsons, Gavin Rintoul, David J. Young

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.

Original languageEnglish
Pages (from-to)165-167
Number of pages3
JournalMain Group Chemistry
Volume1
Issue number1
DOIs
Publication statusPublished - 1995
Externally publishedYes

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Tin Compounds
Tin compounds
tin compounds
Benzoates
Esters
Tin
esters
Cisplatin
Hydrolysis
hydroxides
hydrolysis
tin
triphenyltin

Cite this

Tranter, Carolyn J. ; Berners Price, Susan J. ; Cutts, Janelle ; Parsons, Peter G. ; Rintoul, Gavin ; Young, David J. / A comparison of the potent in vitro antitumor activity of triphenyltin benzoates with that of related tin compounds. In: Main Group Chemistry. 1995 ; Vol. 1, No. 1. pp. 165-167.
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A comparison of the potent in vitro antitumor activity of triphenyltin benzoates with that of related tin compounds. / Tranter, Carolyn J.; Berners Price, Susan J.; Cutts, Janelle; Parsons, Peter G.; Rintoul, Gavin; Young, David J.

In: Main Group Chemistry, Vol. 1, No. 1, 1995, p. 165-167.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Rintoul, Gavin

AU - Young, David J.

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