A comparison of the potent in vitro antitumor activity of triphenyltin benzoates with that of related tin compounds

Carolyn J. Tranter; Susan J. Berners Price; Janelle Cutts; Peter G. Parsons; Gavin Rintoul; David J. Young

doi:10.1080/13583149512331338375

A comparison of the potent in vitro antitumor activity of triphenyltin benzoates with that of related tin compounds

Carolyn J. Tranter, Susan J. Berners Price, Janelle Cutts, Peter G. Parsons, Gavin Rintoul, David J. Young

Research output: Contribution to journal › Article › peer-review

Abstract

A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.

Original language	English
Pages (from-to)	165-167
Number of pages	3
Journal	Main Group Chemistry
Volume	1
Issue number	1
DOIs	https://doi.org/10.1080/13583149512331338375
Publication status	Published - 1995
Externally published	Yes

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title = "A comparison of the potent in vitro antitumor activity of triphenyltin benzoates with that of related tin compounds",

abstract = "A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.",

author = "Tranter, {Carolyn J.} and {Berners Price}, {Susan J.} and Janelle Cutts and Parsons, {Peter G.} and Gavin Rintoul and Young, {David J.}",

year = "1995",

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AU - Tranter, Carolyn J.

AU - Berners Price, Susan J.

AU - Cutts, Janelle

AU - Parsons, Peter G.

AU - Rintoul, Gavin

AU - Young, David J.

PY - 1995

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N2 - A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.

AB - A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.

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JO - Main Group Metal Chemistry

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