Abstract
A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.
| Original language | English |
|---|---|
| Pages (from-to) | 165-167 |
| Number of pages | 3 |
| Journal | Main Group Chemistry |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1995 |
| Externally published | Yes |
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A comparison of the potent in vitro antitumor activity of triphenyltin benzoates with that of related tin compounds. / Tranter, Carolyn J.; Berners Price, Susan J.; Cutts, Janelle; Parsons, Peter G.; Rintoul, Gavin; Young, David J.
In: Main Group Chemistry, Vol. 1, No. 1, 1995, p. 165-167.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - A comparison of the potent in vitro antitumor activity of triphenyltin benzoates with that of related tin compounds
AU - Tranter, Carolyn J.
AU - Berners Price, Susan J.
AU - Cutts, Janelle
AU - Parsons, Peter G.
AU - Rintoul, Gavin
AU - Young, David J.
PY - 1995
Y1 - 1995
N2 - A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.
AB - A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.
UR - http://www.scopus.com/inward/record.url?scp=84974774385&partnerID=8YFLogxK
U2 - 10.1080/13583149512331338375
DO - 10.1080/13583149512331338375
M3 - Article
VL - 1
SP - 165
EP - 167
JO - Main Group Metal Chemistry
JF - Main Group Metal Chemistry
SN - 0792-1241
IS - 1
ER -