TY - JOUR
T1 - A description of lineage 1 Mycobacterium tuberculosis from papua, Indonesia
AU - Djunaedy, Hanif A.K.
AU - Febinia, Clarissa A.
AU - Hamers, Raph L.
AU - Baird, Kevin
AU - Elyazar, Iqbal
AU - Thuong, Nguyen Thuy Thuong
AU - Trimarsanto, Hidayat
AU - Malik, Safarina G.
AU - Thwaites, Guy
AU - van Crevel, Reinout
AU - Alisjahbana, Bachti
AU - Chaidir, Lidya
AU - Ashton, Philip M.
PY - 2024/12
Y1 - 2024/12
N2 - Indonesia has the third highest number of tuberculosis (TB) patients infected with Mycobacterium tuberculosis (MTB) Lineage 1 (L1). Most of these MTB L1 cases can be found in Indonesia's remote easternmost province of Papua, one of Indonesia's most underdeveloped provinces with a particularly high burden for TB. In this study, we sequenced and described 42 MTB L1 isolates from a well-characterized cohort of patients. We found a genetically diverse MTB L1 population with no association between pathogen genetic relatedness and place of residence or pathogen genetic relatedness and patient ethnicity, which could reflect mixing between different locales and ethnicities or our low sampling fraction. Only a small number showed genetic variants associated with drug resistance (5/42, 11.9 %), probably due to a lack of effective treatment programs. The Papuan isolates showed similarities to other Island Southeast Asian Countries due to the high proportion of L1.2.1.2.1 (30/42, 71.4 %), especially East Timor and the Philippines. This study fills a research gap of MTB L1 in Indonesian Papua and should serve as a stepping stone for further research in the region.
AB - Indonesia has the third highest number of tuberculosis (TB) patients infected with Mycobacterium tuberculosis (MTB) Lineage 1 (L1). Most of these MTB L1 cases can be found in Indonesia's remote easternmost province of Papua, one of Indonesia's most underdeveloped provinces with a particularly high burden for TB. In this study, we sequenced and described 42 MTB L1 isolates from a well-characterized cohort of patients. We found a genetically diverse MTB L1 population with no association between pathogen genetic relatedness and place of residence or pathogen genetic relatedness and patient ethnicity, which could reflect mixing between different locales and ethnicities or our low sampling fraction. Only a small number showed genetic variants associated with drug resistance (5/42, 11.9 %), probably due to a lack of effective treatment programs. The Papuan isolates showed similarities to other Island Southeast Asian Countries due to the high proportion of L1.2.1.2.1 (30/42, 71.4 %), especially East Timor and the Philippines. This study fills a research gap of MTB L1 in Indonesian Papua and should serve as a stepping stone for further research in the region.
KW - East-African-Indian (EAI)
KW - Indo-Oceanic strain
KW - Mycobacterium tuberculosis
KW - Papua
KW - Whole-genome sequencing
UR - http://www.scopus.com/inward/record.url?scp=85204736865&partnerID=8YFLogxK
U2 - 10.1016/j.tube.2024.102568
DO - 10.1016/j.tube.2024.102568
M3 - Article
AN - SCOPUS:85204736865
SN - 1472-9792
VL - 149
SP - 1
EP - 8
JO - Tuberculosis
JF - Tuberculosis
M1 - 102568
ER -