The objective of this research was to investigate the acute toxicity of naproxen metal complexes in animal model. A detailed study was done on the physical, biochemical and hormonal parameters of both male and female Swiss-albino mice after 14-day administration of naproxen and its metal complexes. There were no significant changes found in physical parameters observation for both male and female mice without some minor differences. However, naproxen metal complexes showed comparatively lower side effects than naproxen. This might indicated that the carboxylic group of naproxen(-COOH) took part in pathological reactions resulting in side effects in different parts of the organ. There were no significant changes in biochemical parameters, however, the mean value of blood glucose level and cholesterol seemed to be higher and triglyceride was lower. Thyroid hormone levels were found lower that was another indication inflammatory process. However, this might have the ability to lower the insulin secretion resulting in increasing blood glucose level. We did not find any changes in sex hormones level in this study.