Abstract
A new, reliable method for the introduction of an amine group at positions 2 or 6 of β-cyclodextrin and permethyl-β-cyclodextrin is described. It involves selective tosylation followed by azide substitution and almost quantitative reduction with triphenylphosphine followed by hydrolysis of the phosphinimine intermediate.
| Original language | English |
|---|---|
| Pages (from-to) | 7905-7907 |
| Number of pages | 3 |
| Journal | Tetrahedron Letters |
| Volume | 46 |
| Issue number | 46 |
| DOIs | |
| Publication status | Published - 14 Nov 2005 |
| Externally published | Yes |
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Muderawan, I. W., Ong, T. T., Teck, C. L., Young, D. J., Chi, B. C., & Ng, S. C. (2005). A reliable synthesis of 2- and 6-amino-β-cyclodextrin and permethylated-β-cyclodextrin. Tetrahedron Letters, 46(46), 7905-7907. https://doi.org/10.1016/j.tetlet.2005.09.099