A reliable synthesis of 2- and 6-amino-β-cyclodextrin and permethylated-β-cyclodextrin

I. Wayan Muderawan, Teng Teng Ong, Chia Lee Teck, David J. Young, Bun Ching Chi, Siu Choon Ng

Research output: Contribution to journalArticle

Abstract

A new, reliable method for the introduction of an amine group at positions 2 or 6 of β-cyclodextrin and permethyl-β-cyclodextrin is described. It involves selective tosylation followed by azide substitution and almost quantitative reduction with triphenylphosphine followed by hydrolysis of the phosphinimine intermediate.

Original languageEnglish
Pages (from-to)7905-7907
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number46
DOIs
Publication statusPublished - 14 Nov 2005
Externally publishedYes

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