The pace and intensity of social change in modern society is increasing, particularly through advances in modern technology and the remarkable innovations in information and communications technology (ICT), as well as through social movements, especially globalisation (Synott, 2004). This chapter will discuss the concept of globalisation and its impact on the economies, cultures, and international business in developing countries and, in particular, Vietnam. The chapter provides an insight into how national culture and technology affects business operations, including current issues in technological readiness for e-business adoption in Vietnam. By applying theories of globalisation to explain changes and progress in Vietnamese economic development, the chapter also provides a better understanding of the complex mix of culture, technology, and business operations in Vietnam. Recommendations are also made for the development of an appropriate environment for e-business in small to medium enterprises that will further strengthen the country's international business operations.