A volumetric study of molecular inclusion by α-cyclodextrin

Neil S. Isaacs, David J. Young

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The reaction volume (Δ v̄ c→0) associated with inclusion of 3- nitrophenol by αcyclodextrin was determined by densitometry to be -9 cm3 mol-1 while the corresponding value for encapsulation of methyl orange by two molecules of α-cyclodextrin is +27 cm3 mol-1. These volume changes can be interpreted in terms of displacement of solvent from the cavity of α- cyclodextrin and/or changes in solvation of the 'guest' molecule.

Original languageEnglish
Pages (from-to)3953-3956
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number20
DOIs
Publication statusPublished - 14 May 1999
Externally publishedYes

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Cyclodextrins
Molecules
Densitometry
Solvation
Encapsulation

Cite this

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A volumetric study of molecular inclusion by α-cyclodextrin. / Isaacs, Neil S.; Young, David J.

In: Tetrahedron Letters, Vol. 40, No. 20, 14.05.1999, p. 3953-3956.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A volumetric study of molecular inclusion by α-cyclodextrin

AU - Isaacs, Neil S.

AU - Young, David J.

PY - 1999/5/14

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N2 - The reaction volume (Δ v̄ c→0) associated with inclusion of 3- nitrophenol by αcyclodextrin was determined by densitometry to be -9 cm3 mol-1 while the corresponding value for encapsulation of methyl orange by two molecules of α-cyclodextrin is +27 cm3 mol-1. These volume changes can be interpreted in terms of displacement of solvent from the cavity of α- cyclodextrin and/or changes in solvation of the 'guest' molecule.

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KW - Inclusion

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M3 - Article

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