A volumetric study of molecular inclusion by α-cyclodextrin

Neil S. Isaacs, David J. Young

Research output: Contribution to journalArticlepeer-review


The reaction volume (Δ v̄ c→0) associated with inclusion of 3- nitrophenol by αcyclodextrin was determined by densitometry to be -9 cm3 mol-1 while the corresponding value for encapsulation of methyl orange by two molecules of α-cyclodextrin is +27 cm3 mol-1. These volume changes can be interpreted in terms of displacement of solvent from the cavity of α- cyclodextrin and/or changes in solvation of the 'guest' molecule.

Original languageEnglish
Pages (from-to)3953-3956
Number of pages4
JournalTetrahedron Letters
Issue number20
Publication statusPublished - 14 May 1999
Externally publishedYes


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