Abstract
Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Original language | English |
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Pages (from-to) | 250-252 |
Number of pages | 3 |
Journal | Clinical and Vaccine Immunology |
Volume | 21 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2014 |
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Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae. / Smith-Vaughan, Heidi C.; Chang, Anne B.; Sarovich, Derek S.; Marsh, Robyn L.; Grimwood, Keith; Leach, Amanda J.; Morris, Peter S.; Price, Erin P.
In: Clinical and Vaccine Immunology, Vol. 21, No. 2, 02.2014, p. 250-252.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae
AU - Smith-Vaughan, Heidi C.
AU - Chang, Anne B.
AU - Sarovich, Derek S.
AU - Marsh, Robyn L.
AU - Grimwood, Keith
AU - Leach, Amanda J.
AU - Morris, Peter S.
AU - Price, Erin P.
PY - 2014/2
Y1 - 2014/2
N2 - Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
AB - Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
KW - Antigens, Bacterial
KW - Carrier State
KW - Child
KW - Child, Preschool
KW - Cluster Analysis
KW - DNA, Bacterial
KW - Female
KW - Gene Deletion
KW - Genes, Bacterial
KW - Haemophilus Infections
KW - Haemophilus influenzae
KW - Haemophilus Vaccines
KW - Humans
KW - Infant
KW - Male
KW - Phylogeny
KW - World Health
UR - http://www.scopus.com/inward/record.url?scp=84893307727&partnerID=8YFLogxK
U2 - 10.1128/CVI.00632-13
DO - 10.1128/CVI.00632-13
M3 - Article
VL - 21
SP - 250
EP - 252
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
SN - 1071-412X
IS - 2
ER -