Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae

Heidi C. Smith-Vaughan, Anne B. Chang, Derek S. Sarovich, Robyn L. Marsh, Keith Grimwood, Amanda J. Leach, Peter S. Morris, Erin P. Price

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

    Original languageEnglish
    Pages (from-to)250-252
    Number of pages3
    JournalClinical and Vaccine Immunology
    Volume21
    Issue number2
    DOIs
    Publication statusPublished - Feb 2014

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    Haemophilus influenzae
    Haemophilus Vaccines
    Vaccines
    Haemophilus
    Microbiology
    Gene encoding
    Medical problems
    Sequence Analysis
    Proteins
    Genes
    Genome
    Antigens
    Health

    Cite this

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    title = "Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae",
    abstract = "Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively. Copyright {\circledC} 2014, American Society for Microbiology. All Rights Reserved.",
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    author = "Smith-Vaughan, {Heidi C.} and Chang, {Anne B.} and Sarovich, {Derek S.} and Marsh, {Robyn L.} and Keith Grimwood and Leach, {Amanda J.} and Morris, {Peter S.} and Price, {Erin P.}",
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    language = "English",
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    journal = "Clinical and Vaccine Immunology",
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    Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae. / Smith-Vaughan, Heidi C.; Chang, Anne B.; Sarovich, Derek S.; Marsh, Robyn L.; Grimwood, Keith; Leach, Amanda J.; Morris, Peter S.; Price, Erin P.

    In: Clinical and Vaccine Immunology, Vol. 21, No. 2, 02.2014, p. 250-252.

    Research output: Contribution to journalArticleResearchpeer-review

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    AU - Smith-Vaughan, Heidi C.

    AU - Chang, Anne B.

    AU - Sarovich, Derek S.

    AU - Marsh, Robyn L.

    AU - Grimwood, Keith

    AU - Leach, Amanda J.

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