Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae

Heidi C. Smith-Vaughan, Anne B. Chang, Derek S. Sarovich, Robyn L. Marsh, Keith Grimwood, Amanda J. Leach, Peter S. Morris, Erin P. Price

Research output: Contribution to journalArticlepeer-review

Abstract

Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Original languageEnglish
Pages (from-to)250-252
Number of pages3
JournalClinical and Vaccine Immunology
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2014

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