Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae

Heidi C. Smith-Vaughan, Anne B. Chang, Derek S. Sarovich, Robyn L. Marsh, Keith Grimwood, Amanda J. Leach, Peter S. Morris, Erin P. Price

    Research output: Contribution to journal › Article › Research › peer-review

    Abstract

    Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

    Original languageEnglish
    Pages (from-to)250-252
    Number of pages3
    JournalClinical and Vaccine Immunology
    Volume21
    Issue number2
    DOIs
    Publication statusPublished - Feb 2014

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    Haemophilus influenzae
    Haemophilus Vaccines
    Vaccines
    Haemophilus
    Microbiology
    Gene encoding
    Medical problems
    Sequence Analysis
    Proteins
    Genes
    Genome
    Antigens
    Health

    Cite this

    Smith-Vaughan, Heidi C. ; Chang, Anne B. ; Sarovich, Derek S. ; Marsh, Robyn L. ; Grimwood, Keith ; Leach, Amanda J. ; Morris, Peter S. ; Price, Erin P. / Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae. In: Clinical and Vaccine Immunology. 2014 ; Vol. 21, No. 2. pp. 250-252.
    @article{da688393856e4252bbc019ba53233d00,
    title = "Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae",
    abstract = "Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively. Copyright {\circledC} 2014, American Society for Microbiology. All Rights Reserved.",
    keywords = "Antigens, Bacterial, Carrier State, Child, Child, Preschool, Cluster Analysis, DNA, Bacterial, Female, Gene Deletion, Genes, Bacterial, Haemophilus Infections, Haemophilus influenzae, Haemophilus Vaccines, Humans, Infant, Male, Phylogeny, World Health",
    author = "Smith-Vaughan, {Heidi C.} and Chang, {Anne B.} and Sarovich, {Derek S.} and Marsh, {Robyn L.} and Keith Grimwood and Leach, {Amanda J.} and Morris, {Peter S.} and Price, {Erin P.}",
    year = "2014",
    month = "2",
    doi = "10.1128/CVI.00632-13",
    language = "English",
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    pages = "250--252",
    journal = "Clinical and Vaccine Immunology",
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    Smith-Vaughan, HC, Chang, AB, Sarovich, DS, Marsh, RL, Grimwood, K, Leach, AJ, Morris, PS & Price, EP 2014, 'Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae', Clinical and Vaccine Immunology, vol. 21, no. 2, pp. 250-252. https://doi.org/10.1128/CVI.00632-13

    Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae. / Smith-Vaughan, Heidi C.; Chang, Anne B.; Sarovich, Derek S.; Marsh, Robyn L.; Grimwood, Keith; Leach, Amanda J.; Morris, Peter S.; Price, Erin P.

    In: Clinical and Vaccine Immunology, Vol. 21, No. 2, 02.2014, p. 250-252.

    Research output: Contribution to journal › Article › Research › peer-review

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    AU - Smith-Vaughan, Heidi C.

    AU - Chang, Anne B.

    AU - Sarovich, Derek S.

    AU - Marsh, Robyn L.

    AU - Grimwood, Keith

    AU - Leach, Amanda J.

    AU - Morris, Peter S.

    AU - Price, Erin P.

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    AB - Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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    KW - Child, Preschool

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    KW - Genes, Bacterial

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    KW - Haemophilus Vaccines

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    KW - Infant

    KW - Male

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    Smith-Vaughan HC, Chang AB, Sarovich DS, Marsh RL, Grimwood K, Leach AJ et al. Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae. Clinical and Vaccine Immunology. 2014 Feb;21(2):250-252. https://doi.org/10.1128/CVI.00632-13

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