Absence of human papillomavirus in nasopharyngeal swabs from infants in a population at high risk of human papillomavirus infection

Heidi C. Smith-Vaughan; Allen C. Cheng; Sepehr N. Tabrizi; Danielle F. Wurzel; Jemima Beissbarth; Amanda J. Leach; Peter S. Morris; Michael J. Binks; Paul J. Torzillo; Anne B. Chang; Robyn L. Marsh

doi:10.1002/ped4.12262

Absence of human papillomavirus in nasopharyngeal swabs from infants in a population at high risk of human papillomavirus infection

Heidi C. Smith-Vaughan, Allen C. Cheng, Sepehr N. Tabrizi, Danielle F. Wurzel, Jemima Beissbarth, Amanda J. Leach, Peter S. Morris, Michael J. Binks, Paul J. Torzillo, Anne B. Chang, Robyn L. Marsh

Menzies School of Health Research

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Abstract

Maternal urogenital human papillomavirus (HPV) infection may place neonates at risk of HPV acquisition and subsequently lower respiratory infections as HPV can influence development of immunity. The respiratory HPV prevalence is not known in remote-dwelling Aboriginal infants, who are at high risk of respiratory infection and where the population prevalence of urogenital HPV in women is high. These data are necessary to inform HPV vaccination regimens. A retrospective analysis using PCR specific for HPV was performed on 64 stored nasopharyngeal swabs from remote-dwelling Aboriginal infants < 6 months of age, with and without hospitalised pneumonia. HPV DNA was not detected in any specimen. Despite the negative result, we cannot exclude a role for HPV in respiratory infections affecting infants in this population; however, our data do not support HPV as an important contributor to acute respiratory infection in remote-dwelling Aboriginal children.

Original language	English
Pages (from-to)	136-139
Number of pages	4
Journal	Pediatric Investigation
Volume	5
Issue number	2
DOIs	https://doi.org/10.1002/ped4.12262
Publication status	Published - Jun 2021

Bibliographical note

Funding Information:
This work was supported by the Australian National Health and Medical Research Council (NHMRC, GNT1023781); HSV was supported by the NHMRC Centre for Research Excellence for Lung Health in Aboriginal and Torres Strait Islander children (GNT1079557); ABC is funded by a NHMRC Practitioner Fellowship (1154302); ACC was supported by a Career Development Fellowship (1068732).

Publisher Copyright:
© 2021 Chinese Medical Association. Pediatric Investigation published by John Wiley & Sons Australia, Ltd on behalf of Futang Research Center of Pediatric Development.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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10.1002/ped4.12262

44470338-oaFinal published version, 304 KBLicence: CC BY-NC-ND

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Smith-Vaughan, H. C., Cheng, A. C., Tabrizi, S. N., Wurzel, D. F., Beissbarth, J., Leach, A. J., Morris, P. S., Binks, M. J., Torzillo, P. J., Chang, A. B., & Marsh, R. L. (2021). Absence of human papillomavirus in nasopharyngeal swabs from infants in a population at high risk of human papillomavirus infection. Pediatric Investigation, 5(2), 136-139. https://doi.org/10.1002/ped4.12262

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abstract = "Maternal urogenital human papillomavirus (HPV) infection may place neonates at risk of HPV acquisition and subsequently lower respiratory infections as HPV can influence development of immunity. The respiratory HPV prevalence is not known in remote-dwelling Aboriginal infants, who are at high risk of respiratory infection and where the population prevalence of urogenital HPV in women is high. These data are necessary to inform HPV vaccination regimens. A retrospective analysis using PCR specific for HPV was performed on 64 stored nasopharyngeal swabs from remote-dwelling Aboriginal infants < 6 months of age, with and without hospitalised pneumonia. HPV DNA was not detected in any specimen. Despite the negative result, we cannot exclude a role for HPV in respiratory infections affecting infants in this population; however, our data do not support HPV as an important contributor to acute respiratory infection in remote-dwelling Aboriginal children.",

keywords = "Human papillomavirus, Infants, Nasopharyngeal swabs",

author = "Smith-Vaughan, {Heidi C.} and Cheng, {Allen C.} and Tabrizi, {Sepehr N.} and Wurzel, {Danielle F.} and Jemima Beissbarth and Leach, {Amanda J.} and Morris, {Peter S.} and Binks, {Michael J.} and Torzillo, {Paul J.} and Chang, {Anne B.} and Marsh, {Robyn L.}",

note = "Funding Information: This work was supported by the Australian National Health and Medical Research Council (NHMRC, GNT1023781); HSV was supported by the NHMRC Centre for Research Excellence for Lung Health in Aboriginal and Torres Strait Islander children (GNT1079557); ABC is funded by a NHMRC Practitioner Fellowship (1154302); ACC was supported by a Career Development Fellowship (1068732). Publisher Copyright: {\textcopyright} 2021 Chinese Medical Association. Pediatric Investigation published by John Wiley & Sons Australia, Ltd on behalf of Futang Research Center of Pediatric Development. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

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doi = "10.1002/ped4.12262",

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Absence of human papillomavirus in nasopharyngeal swabs from infants in a population at high risk of human papillomavirus infection

Abstract

Bibliographical note

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