TY - JOUR
T1 - Acceptorless dehydrogenative coupling with Ru-based catalysts for the synthesis of N-heteroaromatic compounds
AU - Zhang, Jing
AU - Guo, Bin
AU - Young, David James
AU - Li, Hong Xi
PY - 2020/11/28
Y1 - 2020/11/28
N2 - Ru-Catalyzed acceptorless dehydrogenative coupling (ADC) and auto-transfer-hydrogenative (ATH) reactions are effective, versatile transformations for the constructions of N-heteroaromatic compounds from alcohols. Water and hydrogen are the by-products and the starting alcohols are less toxic, more readily available and more easily handled than their halogenated counterparts. A variety of homogeneous ruthenium catalysts, alcohols and partner-substrates such as amines, ammonia, amidines and nitriles, have been used to build N-heteroaromatic compounds in one-pot, multi-step syntheses. This review details recently reported Ru catalysts employed for these reactions, describing the scope of each methodology, proposed reaction mechanisms, regioselectivity of coupling and applications in synthesis.
AB - Ru-Catalyzed acceptorless dehydrogenative coupling (ADC) and auto-transfer-hydrogenative (ATH) reactions are effective, versatile transformations for the constructions of N-heteroaromatic compounds from alcohols. Water and hydrogen are the by-products and the starting alcohols are less toxic, more readily available and more easily handled than their halogenated counterparts. A variety of homogeneous ruthenium catalysts, alcohols and partner-substrates such as amines, ammonia, amidines and nitriles, have been used to build N-heteroaromatic compounds in one-pot, multi-step syntheses. This review details recently reported Ru catalysts employed for these reactions, describing the scope of each methodology, proposed reaction mechanisms, regioselectivity of coupling and applications in synthesis.
UR - http://www.scopus.com/inward/record.url?scp=85096362928&partnerID=8YFLogxK
U2 - 10.1039/d0dt03282d
DO - 10.1039/d0dt03282d
M3 - Review article
C2 - 33107541
AN - SCOPUS:85096362928
VL - 49
SP - 15527
EP - 15547
JO - Dalton Transactions: an international journal of inorganic chemistry
JF - Dalton Transactions: an international journal of inorganic chemistry
SN - 1477-9226
IS - 44
ER -