TY - JOUR
T1 - Acceptorless dehydrogenative coupling with Ru-based catalysts for the synthesis of N-heteroaromatic compounds
AU - Zhang, Jing
AU - Guo, Bin
AU - Young, David James
AU - Li, Hong Xi
PY - 2020/11/28
Y1 - 2020/11/28
N2 - Ru-Catalyzed acceptorless dehydrogenative coupling (ADC) and auto-transfer-hydrogenative (ATH) reactions are effective, versatile transformations for the constructions of N-heteroaromatic compounds from alcohols. Water and hydrogen are the by-products and the starting alcohols are less toxic, more readily available and more easily handled than their halogenated counterparts. A variety of homogeneous ruthenium catalysts, alcohols and partner-substrates such as amines, ammonia, amidines and nitriles, have been used to build N-heteroaromatic compounds in one-pot, multi-step syntheses. This review details recently reported Ru catalysts employed for these reactions, describing the scope of each methodology, proposed reaction mechanisms, regioselectivity of coupling and applications in synthesis. This journal is
AB - Ru-Catalyzed acceptorless dehydrogenative coupling (ADC) and auto-transfer-hydrogenative (ATH) reactions are effective, versatile transformations for the constructions of N-heteroaromatic compounds from alcohols. Water and hydrogen are the by-products and the starting alcohols are less toxic, more readily available and more easily handled than their halogenated counterparts. A variety of homogeneous ruthenium catalysts, alcohols and partner-substrates such as amines, ammonia, amidines and nitriles, have been used to build N-heteroaromatic compounds in one-pot, multi-step syntheses. This review details recently reported Ru catalysts employed for these reactions, describing the scope of each methodology, proposed reaction mechanisms, regioselectivity of coupling and applications in synthesis. This journal is
UR - http://www.scopus.com/inward/record.url?scp=85096362928&partnerID=8YFLogxK
U2 - 10.1039/d0dt03282d
DO - 10.1039/d0dt03282d
M3 - Review article
C2 - 33107541
AN - SCOPUS:85096362928
VL - 49
SP - 15527
EP - 15547
JO - Dalton Transactions: an international journal of inorganic chemistry
JF - Dalton Transactions: an international journal of inorganic chemistry
SN - 1477-9226
IS - 44
ER -