Acute Post-Streptococcal Glomerulonephritis in the Northern Territory of Australia

A Review of 16 Years Data and Comparison with the Literature

Marshall Catherine, A CHENG, Peter Markey, Rebecca Towers, Leisha Jade Richardson, Peter Fagan, Lesley Scott, Vicki Krause, Bart Currie

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Data relating to acute post-streptococcal glomerulonephritis (APSGN) from the notifiable diseases surveillance system in the Northern Territory of Australia was extracted and analyzed. Isolates of Streptococcus pyogenes from confirmed cases were emm sequence typed. From 1991 to July 2008, there were 415 confirmed cases and 23 probable cases of APSGN notified. Four hundred fifteen (94.7%) of these were Indigenous Australians and 428 (97.7%) were people living in remote or very remote locations. The median age of cases was 7 years (range 0-54). The incidence of confirmed cases was 12.5/100,000 person-years, with an incidence in Indigenous Australian children younger than 15 years of age of 94.3 cases/100,000 person-years. The overall rate ratio of confirmed cases in Indigenous Australians to non-Indigenous Australians was 53.6 (95% confidence interval 32.6-94.8). Outbreaks of disease across multiple communities occurred in 1995 (N = 68), 2000 (N = 55), and 2005 (N = 87 [confirmed cases]). Various emm types of S. pyogenes were isolated from cases of APSGN including some types not previously recognized to be nephritogenic. The widespread outbreak in 2005 was caused by emm55.0 S. pyogenes. Acute post-streptococcal glomerulonephritis continues to occur in remote Indigenous communities in Australia at rates comparable to or higher than those estimated in developing countries. Improvements in preventative and outbreak control strategies are needed. Copyright � 2011 by The American Society of Tropical Medicine and Hygiene.
    Original languageEnglish
    Pages (from-to)703-710
    Number of pages8
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume85
    Issue number4
    DOIs
    Publication statusPublished - 2011

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    Northern Territory
    Glomerulonephritis
    Streptococcus pyogenes
    Disease Outbreaks
    Incidence
    Developing Countries
    Confidence Intervals

    Cite this

    Catherine, Marshall ; CHENG, A ; Markey, Peter ; Towers, Rebecca ; Richardson, Leisha Jade ; Fagan, Peter ; Scott, Lesley ; Krause, Vicki ; Currie, Bart. / Acute Post-Streptococcal Glomerulonephritis in the Northern Territory of Australia : A Review of 16 Years Data and Comparison with the Literature. In: American Journal of Tropical Medicine and Hygiene. 2011 ; Vol. 85, No. 4. pp. 703-710.
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    abstract = "Data relating to acute post-streptococcal glomerulonephritis (APSGN) from the notifiable diseases surveillance system in the Northern Territory of Australia was extracted and analyzed. Isolates of Streptococcus pyogenes from confirmed cases were emm sequence typed. From 1991 to July 2008, there were 415 confirmed cases and 23 probable cases of APSGN notified. Four hundred fifteen (94.7{\%}) of these were Indigenous Australians and 428 (97.7{\%}) were people living in remote or very remote locations. The median age of cases was 7 years (range 0-54). The incidence of confirmed cases was 12.5/100,000 person-years, with an incidence in Indigenous Australian children younger than 15 years of age of 94.3 cases/100,000 person-years. The overall rate ratio of confirmed cases in Indigenous Australians to non-Indigenous Australians was 53.6 (95{\%} confidence interval 32.6-94.8). Outbreaks of disease across multiple communities occurred in 1995 (N = 68), 2000 (N = 55), and 2005 (N = 87 [confirmed cases]). Various emm types of S. pyogenes were isolated from cases of APSGN including some types not previously recognized to be nephritogenic. The widespread outbreak in 2005 was caused by emm55.0 S. pyogenes. Acute post-streptococcal glomerulonephritis continues to occur in remote Indigenous communities in Australia at rates comparable to or higher than those estimated in developing countries. Improvements in preventative and outbreak control strategies are needed. Copyright � 2011 by The American Society of Tropical Medicine and Hygiene.",
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    Acute Post-Streptococcal Glomerulonephritis in the Northern Territory of Australia : A Review of 16 Years Data and Comparison with the Literature. / Catherine, Marshall; CHENG, A; Markey, Peter; Towers, Rebecca; Richardson, Leisha Jade; Fagan, Peter; Scott, Lesley; Krause, Vicki; Currie, Bart.

    In: American Journal of Tropical Medicine and Hygiene, Vol. 85, No. 4, 2011, p. 703-710.

    Research output: Contribution to journalArticleResearchpeer-review

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