Acyl Radicals from α-Keto Acids Using a Carbonyl Photocatalyst: Photoredox-Catalyzed Synthesis of Ketones

Da Liang Zhu; Qi Wu; David James Young; Hao Wang; Zhi Gang Ren; Hong Xi Li

doi:10.1021/acs.orglett.0c02351

Acyl Radicals from α-Keto Acids Using a Carbonyl Photocatalyst: Photoredox-Catalyzed Synthesis of Ketones

Da Liang Zhu, Qi Wu, David James Young, Hao Wang, Zhi Gang Ren, Hong Xi Li

Research output: Contribution to journal › Article › peer-review

Abstract

Acyl radicals have been generated from α-keto acids using inexpensive and commercially available 2-chloro-thioxanthen-9-one as the photoredox catalyst under visible light illumination. These reactive species added to olefins or coupled with aryl halides via a bipyridyl-stabilized Ni(II) catalyst, enabling easy access to a diverse range of ketones. This reliable, atom-economical, and eco-friendly protocol is compatible with a wide range of functional groups.

Original language	English
Pages (from-to)	6832-6837
Number of pages	6
Journal	Organic Letters
Volume	22
Issue number	17
DOIs	https://doi.org/10.1021/acs.orglett.0c02351
Publication status	Published - 4 Sept 2020

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abstract = "Acyl radicals have been generated from α-keto acids using inexpensive and commercially available 2-chloro-thioxanthen-9-one as the photoredox catalyst under visible light illumination. These reactive species added to olefins or coupled with aryl halides via a bipyridyl-stabilized Ni(II) catalyst, enabling easy access to a diverse range of ketones. This reliable, atom-economical, and eco-friendly protocol is compatible with a wide range of functional groups.",

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T2 - Photoredox-Catalyzed Synthesis of Ketones

AU - Zhu, Da Liang

AU - Wu, Qi

AU - Young, David James

AU - Wang, Hao

AU - Ren, Zhi Gang

AU - Li, Hong Xi

PY - 2020/9/4

Y1 - 2020/9/4

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AB - Acyl radicals have been generated from α-keto acids using inexpensive and commercially available 2-chloro-thioxanthen-9-one as the photoredox catalyst under visible light illumination. These reactive species added to olefins or coupled with aryl halides via a bipyridyl-stabilized Ni(II) catalyst, enabling easy access to a diverse range of ketones. This reliable, atom-economical, and eco-friendly protocol is compatible with a wide range of functional groups.

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Acyl Radicals from α-Keto Acids Using a Carbonyl Photocatalyst: Photoredox-Catalyzed Synthesis of Ketones

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