Acyl Radicals from α-Keto Acids Using a Carbonyl Photocatalyst: Photoredox-Catalyzed Synthesis of Ketones

Da Liang Zhu, Qi Wu, David James Young, Hao Wang, Zhi Gang Ren, Hong Xi Li

Research output: Contribution to journalArticle

Abstract

Acyl radicals have been generated from α-keto acids using inexpensive and commercially available 2-chloro-thioxanthen-9-one as the photoredox catalyst under visible light illumination. These reactive species added to olefins or coupled with aryl halides via a bipyridyl-stabilized Ni(II) catalyst, enabling easy access to a diverse range of ketones. This reliable, atom-economical, and eco-friendly protocol is compatible with a wide range of functional groups.

Original languageEnglish
Pages (from-to)6832-6837
Number of pages6
JournalOrganic Letters
Volume22
Issue number17
DOIs
Publication statusPublished - 4 Sep 2020

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