Adalimumab for corticosteroid and infliximab-resistant immune reconstitution inflammatory syndrome in the setting of TB/HIV coinfection

Nilar Lwin, Michael Boyle, Joshua S. Davis

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Corticosteroids are the mainstay of therapy for immune reconstitution inflammatory syndrome (IRIS). However, little is known about how to treat IRIS unresponsive to steroids. We report a patient with HIV-TB coinfection who was unresponsive to first prednisolone and then infliximab but whose IRIS resolved with adalimumab.

LanguageEnglish
Article numberofy027
Pages1-3
Number of pages3
JournalOpen Forum Infectious Diseases
Volume5
Issue number2
DOIs
StatePublished - 1 Feb 2018

Fingerprint

Immune Reconstitution Inflammatory Syndrome
Coinfection
Adrenal Cortex Hormones
HIV
Prednisolone
Steroids
Infliximab
Adalimumab
Therapeutics

Cite this

@article{1d7331863f85472f8f8f6732fcfaed65,
title = "Adalimumab for corticosteroid and infliximab-resistant immune reconstitution inflammatory syndrome in the setting of TB/HIV coinfection",
abstract = "Corticosteroids are the mainstay of therapy for immune reconstitution inflammatory syndrome (IRIS). However, little is known about how to treat IRIS unresponsive to steroids. We report a patient with HIV-TB coinfection who was unresponsive to first prednisolone and then infliximab but whose IRIS resolved with adalimumab.",
keywords = "Adalimumab, HIV, Immune reconstitution, Steroid, Tuberculosis",
author = "Nilar Lwin and Michael Boyle and Davis, {Joshua S.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1093/ofid/ofy027",
language = "English",
volume = "5",
pages = "1--3",
journal = "Open Forum Infectious Diseases",
issn = "2328-8957",
publisher = "Oxford University Press",
number = "2",

}

Adalimumab for corticosteroid and infliximab-resistant immune reconstitution inflammatory syndrome in the setting of TB/HIV coinfection. / Lwin, Nilar; Boyle, Michael; Davis, Joshua S.

In: Open Forum Infectious Diseases, Vol. 5, No. 2, ofy027, 01.02.2018, p. 1-3.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Adalimumab for corticosteroid and infliximab-resistant immune reconstitution inflammatory syndrome in the setting of TB/HIV coinfection

AU - Lwin,Nilar

AU - Boyle,Michael

AU - Davis,Joshua S.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Corticosteroids are the mainstay of therapy for immune reconstitution inflammatory syndrome (IRIS). However, little is known about how to treat IRIS unresponsive to steroids. We report a patient with HIV-TB coinfection who was unresponsive to first prednisolone and then infliximab but whose IRIS resolved with adalimumab.

AB - Corticosteroids are the mainstay of therapy for immune reconstitution inflammatory syndrome (IRIS). However, little is known about how to treat IRIS unresponsive to steroids. We report a patient with HIV-TB coinfection who was unresponsive to first prednisolone and then infliximab but whose IRIS resolved with adalimumab.

KW - Adalimumab

KW - HIV

KW - Immune reconstitution

KW - Steroid

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=85044416487&partnerID=8YFLogxK

U2 - 10.1093/ofid/ofy027

DO - 10.1093/ofid/ofy027

M3 - Article

VL - 5

SP - 1

EP - 3

JO - Open Forum Infectious Diseases

T2 - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

SN - 2328-8957

IS - 2

M1 - ofy027

ER -