Admixture into and within sub-Saharan Africa

George B.J. Busby; Gavin Band; Quang Si Le; Muminatou Jallow; Edith Bougama; Valentina D. Mangano; Lucas N. Amenga-Etego; Anthony Enimil; Tobias O. Apinjoh; Carolyne M. Ndila; Alphaxard Manjurano; Vysaul Nyirongo; Ogobara Doumba; Kirk A. Rockett; Dominic P. Kwiatkowski; Chris C.A. Spencer; Aaron Vanderwal; Abier Elzein; Aceme Nyika; Alieu Mendy; Alistair Miles; Andrea Diss; Angeliki Kerasidou; Angie Green; Anna E. Jeffreys; Bronwyn MacInnis; Catherine Hughes; Catherine Moyes; Christina Hubbart; Cinzia Malangone; Claire Potter; Daniel Mead; David Barnwell; Dushyanth Jyothi; Eleanor Drury; Elilan Somaskantharajah; Eliza Hilton; Ellen Leffler; Gareth Maslen; George Busby; Geraldine M Clarke; Ioannis Ragoussis; Jacob Almagro Garcia; Jane Rogers; Jantina deVries; Jennifer M G Shelton; Jiannis Ragoussis; Jim Stalker; Joanne Rodford; John O'Brien; Julie Evans; Kate Rowlands; Katharine Cook; Kathryn Fitzpatrick; Katja Kivinen; Kerrin Small; Kimberly J. Johnson; Lee Hart; Magnus Manske; Marilyn McCreight; Marryat Stevens; Matti Pirinen; Meike Hennsman; Michael Parker; Miguel SanJoaquin; Nuno Seplúveda; Olivia Cook; Olivo Miotto; Panos Deloukas; Rachel Craik; Rebecca Wrigley; Renee Watson; Richard D Pearson; Robert Hutton; Samuel Oyola; Sarah Auburn; Shivang Shah; Si Quang Le; Sile Molloy; Susan Bull; Susana Campino; Taane G. Clark; Valentín Ruano-Rubio; Victoria Cornelius; Yik Ying Teo; Patrick Corran; Nilupa Silva; Paul Risley; Alan Doyle; Jennifer Evans; Rolf Horstmann; Chris Plowe; Patrick Duffy; Dan Carucci; Michael Gottleib; Adama Tall; Alioune Badara Ly; Amagana Dolo; Anavaj Sakuntabhai; Odile Puijalon; Abdou Bah; Abdoulie Camara; Abubacar Sadiq; Aja Abie Khan; Amie Jobarteh; Anthony Mendy; Augustine Ebonyi; Bakary Danso; Bintou Taal; Climent Casals-Pascual; David J. Conway; Emmanuel Onykwelu; Fatoumatta Sisay-Joof; Giorgio Sirugo; Haddy Kanyi; Haddy Njie; Herbert Obu; Horeja Saine; Idrissa Sambou; Ismaela Abubakar; Jalimory Njie; Jula Jaiteh; Kalifa A. Bojang; Kebba Jammeh; Kumba Sabally-Ceesay; Lamin Manneh; Landing Camara; Lawrence Yamoah; Madi Njie; Margaret Pinder; Mariatou Jallow; Mohammed Aiyegbo; Momodou Jasseh; Momodou Lamin Keita; Momodou Saidy-Khan; Ndey Ceesay; Oba Rasheed; Pa Lamin Ceesay; Pamela Esangbedo; Ramou Cole-Ceesay; Rasaq Olaosebikan; Simon Correa; Sophie Njie; Stanley Usen; Yaya Dibba; Abdoulaye Barry; A. Djimdé; Abdourahmane H. Sall; Amadou Abathina; Amadou Niangaly; Awa Dembele; Belco Poudiougou; Elizabeth Diarra; Kariatou Bamba; Mahamadou A. Thera; Ogobara Doumbo; Ousmane Toure; Salimata Konate; Sibiry Sissoko; Mahamadou Diakite; Amadou T. Konate; David Modiano; Edith C. Bougouma; Germana Bancone; Issa N. Ouedraogo; Jaques Simpore; Sodiomon B. Sirima; Marita Troye-Blomberg; Abraham R. Oduro; Abraham V.O. Hodgson; Anita Ghansah; Francis Nkrumah; Frank Atuguba; Kwadwo A. Koram; Michael D. Wilson; Nana Akosua Ansah; Nathan Mensah; Patrick A. Ansah; Thomas Anyorigiya; Victor Asoala; William O. Rogers; Alex Osei Akoto; Alex Owusu Ofori; Daniel Ansong; David Sambian; Emmanuel Asafo-Agyei; Justice Sylverken; Sampson Antwi; Tsiri Agbenyega; Adebola E. Orimadegun; Folakemi Anjol Amodu; Olajumoke Oni; Olayemi O. Omotade; Olukemi Amodu; Subulade Olaniyan; Andre Ndi; Clarisse Yafi; Eric Akum Achidi; Eric Mbunwe; Judith Anchang-Kimbi; Regina Mugri; Richard Besingi; Tobias O. Apinjoh; Vincent Titanji; Ahmed Elhassan; Ayman Hussein; Hiba Mohamed; Ibrahim Elhassan; Muntaser Ibrahim; Gilbert Kokwaro; Tom Oluoch; Alexander Macharia; Charles Newton; Daniel H. Opi; Dorcas Kamuya; Evasius Bauni; Kevin Marsh; Norbert Peshu; Sassy Molyneux; Sophie Uyoga; Thomas N Williams; Vicki Marsh; Behzad Nadjm; Caroline Maxwell; Chris Drakeley; Eleanor Riley; Frank Mtei; George Mtove; Hannah Wangai; Hugh Reyburn; Sarah Joseph; Deus Ishengoma; Martha Lemnge; Theonest Mutabingwa; Julie Makani; Sharon Cox; Ajib Phiri; Annie Munthali; David Kachala; Labes Njiragoma; Malcolm E. Molyneux; Mike Moore; Neema Ntunthama; Paul Pensulo; Terrie Taylor; Richard Carter; Deepika Fernando; Nadira Karunaweera; Rajika Dewasurendra; Prapat Suriyaphol; Malaria Genomic Epidemiology Network

doi:10.7554/eLife.15266.001

Admixture into and within sub-Saharan Africa

George B.J. Busby, Gavin Band, Quang Si Le, Muminatou Jallow, Edith Bougama, Valentina D. Mangano, Lucas N. Amenga-Etego, Anthony Enimil, Tobias O. Apinjoh, Carolyne M. Ndila, Alphaxard Manjurano, Vysaul Nyirongo, Ogobara Doumba, Kirk A. Rockett, Dominic P. Kwiatkowski, Chris C.A. Spencer, Aaron Vanderwal, Abier Elzein, Aceme Nyika, Alieu MendyAlistair Miles, Andrea Diss, Angeliki Kerasidou, Angie Green, Anna E. Jeffreys, Bronwyn MacInnis, Catherine Hughes, Catherine Moyes, Christina Hubbart, Cinzia Malangone, Claire Potter, Daniel Mead, David Barnwell, Dushyanth Jyothi, Eleanor Drury, Elilan Somaskantharajah, Eliza Hilton, Ellen Leffler, Gareth Maslen, George Busby, Geraldine M Clarke, Ioannis Ragoussis, Jacob Almagro Garcia, Jane Rogers, Jantina deVries, Jennifer M G Shelton, Jiannis Ragoussis, Jim Stalker, Joanne Rodford, John O'Brien, Julie Evans, Kate Rowlands, Katharine Cook, Kathryn Fitzpatrick, Katja Kivinen, Kerrin Small, Kimberly J. Johnson, Lee Hart, Magnus Manske, Marilyn McCreight, Marryat Stevens, Matti Pirinen, Meike Hennsman, Michael Parker, Miguel SanJoaquin, Nuno Seplúveda, Olivia Cook, Olivo Miotto, Panos Deloukas, Rachel Craik, Rebecca Wrigley, Renee Watson, Richard D Pearson, Robert Hutton, Samuel Oyola, Sarah Auburn, Shivang Shah, Si Quang Le, Sile Molloy, Susan Bull, Susana Campino, Taane G. Clark, Valentín Ruano-Rubio, Victoria Cornelius, Yik Ying Teo, Patrick Corran, Nilupa Silva, Paul Risley, Alan Doyle, Jennifer Evans, Rolf Horstmann, Chris Plowe, Patrick Duffy, Dan Carucci, Michael Gottleib, Adama Tall, Alioune Badara Ly, Amagana Dolo, Anavaj Sakuntabhai, Odile Puijalon, Abdou Bah, Abdoulie Camara, Abubacar Sadiq, Aja Abie Khan, Amie Jobarteh, Anthony Mendy, Augustine Ebonyi, Bakary Danso, Bintou Taal, Climent Casals-Pascual, David J. Conway, Emmanuel Onykwelu, Fatoumatta Sisay-Joof, Giorgio Sirugo, Haddy Kanyi, Haddy Njie, Herbert Obu, Horeja Saine, Idrissa Sambou, Ismaela Abubakar, Jalimory Njie, Jula Jaiteh, Kalifa A. Bojang, Kebba Jammeh, Kumba Sabally-Ceesay, Lamin Manneh, Landing Camara, Lawrence Yamoah, Madi Njie, Margaret Pinder, Mariatou Jallow, Mohammed Aiyegbo, Momodou Jasseh, Momodou Lamin Keita, Momodou Saidy-Khan, Ndey Ceesay, Oba Rasheed, Pa Lamin Ceesay, Pamela Esangbedo, Ramou Cole-Ceesay, Rasaq Olaosebikan, Simon Correa, Sophie Njie, Stanley Usen, Yaya Dibba, Abdoulaye Barry, A. Djimdé, Abdourahmane H. Sall, Amadou Abathina, Amadou Niangaly, Awa Dembele, Belco Poudiougou, Elizabeth Diarra, Kariatou Bamba, Mahamadou A. Thera, Ogobara Doumbo, Ousmane Toure, Salimata Konate, Sibiry Sissoko, Mahamadou Diakite, Amadou T. Konate, David Modiano, Edith C. Bougouma, Germana Bancone, Issa N. Ouedraogo, Jaques Simpore, Sodiomon B. Sirima, Marita Troye-Blomberg, Abraham R. Oduro, Abraham V.O. Hodgson, Anita Ghansah, Francis Nkrumah, Frank Atuguba, Kwadwo A. Koram, Michael D. Wilson, Nana Akosua Ansah, Nathan Mensah, Patrick A. Ansah, Thomas Anyorigiya, Victor Asoala, William O. Rogers, Alex Osei Akoto, Alex Owusu Ofori, Daniel Ansong, David Sambian, Emmanuel Asafo-Agyei, Justice Sylverken, Sampson Antwi, Tsiri Agbenyega, Adebola E. Orimadegun, Folakemi Anjol Amodu, Olajumoke Oni, Olayemi O. Omotade, Olukemi Amodu, Subulade Olaniyan, Andre Ndi, Clarisse Yafi, Eric Akum Achidi, Eric Mbunwe, Judith Anchang-Kimbi, Regina Mugri, Richard Besingi, Tobias O. Apinjoh, Vincent Titanji, Ahmed Elhassan, Ayman Hussein, Hiba Mohamed, Ibrahim Elhassan, Muntaser Ibrahim, Gilbert Kokwaro, Tom Oluoch, Alexander Macharia, Charles Newton, Daniel H. Opi, Dorcas Kamuya, Evasius Bauni, Kevin Marsh, Norbert Peshu, Sassy Molyneux, Sophie Uyoga, Thomas N Williams, Vicki Marsh, Behzad Nadjm, Caroline Maxwell, Chris Drakeley, Eleanor Riley, Frank Mtei, George Mtove, Hannah Wangai, Hugh Reyburn, Sarah Joseph, Deus Ishengoma, Martha Lemnge, Theonest Mutabingwa, Julie Makani, Sharon Cox, Ajib Phiri, Annie Munthali, David Kachala, Labes Njiragoma, Malcolm E. Molyneux, Mike Moore, Neema Ntunthama, Paul Pensulo, Terrie Taylor, Richard Carter, Deepika Fernando, Nadira Karunaweera, Rajika Dewasurendra, Prapat Suriyaphol, Malaria Genomic Epidemiology Network

Research output: Contribution to journal › Article › peer-review

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Abstract

Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.

Original language	English
Article number	e15266
Pages (from-to)	1-44
Number of pages	44
Journal	eLife
Volume	5
Issue number	JUN2016
DOIs	https://doi.org/10.7554/eLife.15266.001
Publication status	Published - 21 Jun 2016
Externally published	Yes

Access to Document

10.7554/eLife.15266.001Licence: CC BY

10019272-oaFinal published version, 3.81 MBLicence: CC BY

Cite this

Busby, G. B. J., Band, G., Le, Q. S., Jallow, M., Bougama, E., Mangano, V. D., Amenga-Etego, L. N., Enimil, A., Apinjoh, T. O., Ndila, C. M., Manjurano, A., Nyirongo, V., Doumba, O., Rockett, K. A., Kwiatkowski, D. P., Spencer, C. C. A., Vanderwal, A., Elzein, A., Nyika, A., ... Malaria Genomic Epidemiology Network (2016). Admixture into and within sub-Saharan Africa. eLife, 5(JUN2016), 1-44. [e15266]. https://doi.org/10.7554/eLife.15266.001

@article{2370862a7a984722a508a8c88563c184,

title = "Admixture into and within sub-Saharan Africa",

abstract = "Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.",

author = "Busby, {George B.J.} and Gavin Band and Le, {Quang Si} and Muminatou Jallow and Edith Bougama and Mangano, {Valentina D.} and Amenga-Etego, {Lucas N.} and Anthony Enimil and Apinjoh, {Tobias O.} and Ndila, {Carolyne M.} and Alphaxard Manjurano and Vysaul Nyirongo and Ogobara Doumba and Rockett, {Kirk A.} and Kwiatkowski, {Dominic P.} and Spencer, {Chris C.A.} and Aaron Vanderwal and Abier Elzein and Aceme Nyika and Alieu Mendy and Alistair Miles and Andrea Diss and Angeliki Kerasidou and Angie Green and Jeffreys, {Anna E.} and Bronwyn MacInnis and Catherine Hughes and Catherine Moyes and Christina Hubbart and Cinzia Malangone and Claire Potter and Daniel Mead and David Barnwell and Dushyanth Jyothi and Eleanor Drury and Elilan Somaskantharajah and Eliza Hilton and Ellen Leffler and Gareth Maslen and George Busby and Clarke, {Geraldine M} and Ioannis Ragoussis and Garcia, {Jacob Almagro} and Jane Rogers and Jantina deVries and Shelton, {Jennifer M G} and Jiannis Ragoussis and Jim Stalker and Joanne Rodford and John O'Brien and Julie Evans and Kate Rowlands and Katharine Cook and Kathryn Fitzpatrick and Katja Kivinen and Kerrin Small and Johnson, {Kimberly J.} and Lee Hart and Magnus Manske and Marilyn McCreight and Marryat Stevens and Matti Pirinen and Meike Hennsman and Michael Parker and Miguel SanJoaquin and Nuno Sepl{\'u}veda and Olivia Cook and Olivo Miotto and Panos Deloukas and Rachel Craik and Rebecca Wrigley and Renee Watson and Pearson, {Richard D} and Robert Hutton and Samuel Oyola and Sarah Auburn and Shivang Shah and Le, {Si Quang} and Sile Molloy and Susan Bull and Susana Campino and Clark, {Taane G.} and Valent{\'i}n Ruano-Rubio and Victoria Cornelius and Teo, {Yik Ying} and Patrick Corran and Nilupa Silva and Paul Risley and Alan Doyle and Jennifer Evans and Rolf Horstmann and Chris Plowe and Patrick Duffy and Dan Carucci and Michael Gottleib and Adama Tall and Ly, {Alioune Badara} and Amagana Dolo and Anavaj Sakuntabhai and Odile Puijalon and Abdou Bah and Abdoulie Camara and Abubacar Sadiq and {Abie Khan}, Aja and Amie Jobarteh and Anthony Mendy and Augustine Ebonyi and Bakary Danso and Bintou Taal and Climent Casals-Pascual and Conway, {David J.} and Emmanuel Onykwelu and Fatoumatta Sisay-Joof and Giorgio Sirugo and Haddy Kanyi and Haddy Njie and Herbert Obu and Horeja Saine and Idrissa Sambou and Ismaela Abubakar and Jalimory Njie and Jula Jaiteh and Bojang, {Kalifa A.} and Kebba Jammeh and Kumba Sabally-Ceesay and Lamin Manneh and Landing Camara and Lawrence Yamoah and Madi Njie and Margaret Pinder and Mariatou Jallow and Mohammed Aiyegbo and Momodou Jasseh and Keita, {Momodou Lamin} and Momodou Saidy-Khan and Ndey Ceesay and Oba Rasheed and Ceesay, {Pa Lamin} and Pamela Esangbedo and Ramou Cole-Ceesay and Rasaq Olaosebikan and Simon Correa and Sophie Njie and Stanley Usen and Yaya Dibba and Abdoulaye Barry and A. Djimd{\'e} and Sall, {Abdourahmane H.} and Amadou Abathina and Amadou Niangaly and Awa Dembele and Belco Poudiougou and Elizabeth Diarra and Kariatou Bamba and Thera, {Mahamadou A.} and Ogobara Doumbo and Ousmane Toure and Salimata Konate and Sibiry Sissoko and Mahamadou Diakite and Konate, {Amadou T.} and David Modiano and Bougouma, {Edith C.} and Germana Bancone and Ouedraogo, {Issa N.} and Jaques Simpore and Sirima, {Sodiomon B.} and Marita Troye-Blomberg and Oduro, {Abraham R.} and Hodgson, {Abraham V.O.} and Anita Ghansah and Francis Nkrumah and Frank Atuguba and Koram, {Kwadwo A.} and Wilson, {Michael D.} and Ansah, {Nana Akosua} and Nathan Mensah and Ansah, {Patrick A.} and Thomas Anyorigiya and Victor Asoala and Rogers, {William O.} and Akoto, {Alex Osei} and Ofori, {Alex Owusu} and Daniel Ansong and David Sambian and Emmanuel Asafo-Agyei and Justice Sylverken and Sampson Antwi and Tsiri Agbenyega and Orimadegun, {Adebola E.} and Amodu, {Folakemi Anjol} and Olajumoke Oni and Omotade, {Olayemi O.} and Olukemi Amodu and Subulade Olaniyan and Andre Ndi and Clarisse Yafi and Achidi, {Eric Akum} and Eric Mbunwe and Judith Anchang-Kimbi and Regina Mugri and Richard Besingi and Apinjoh, {Tobias O.} and Vincent Titanji and Ahmed Elhassan and Ayman Hussein and Hiba Mohamed and Ibrahim Elhassan and Muntaser Ibrahim and Gilbert Kokwaro and Tom Oluoch and Alexander Macharia and Charles Newton and Opi, {Daniel H.} and Dorcas Kamuya and Evasius Bauni and Kevin Marsh and Norbert Peshu and Sassy Molyneux and Sophie Uyoga and Williams, {Thomas N} and Vicki Marsh and Behzad Nadjm and Caroline Maxwell and Chris Drakeley and Eleanor Riley and Frank Mtei and George Mtove and Hannah Wangai and Hugh Reyburn and Sarah Joseph and Deus Ishengoma and Martha Lemnge and Theonest Mutabingwa and Julie Makani and Sharon Cox and Ajib Phiri and Annie Munthali and David Kachala and Labes Njiragoma and Molyneux, {Malcolm E.} and Mike Moore and Neema Ntunthama and Paul Pensulo and Terrie Taylor and Richard Carter and Deepika Fernando and Nadira Karunaweera and Rajika Dewasurendra and Prapat Suriyaphol and {Malaria Genomic Epidemiology Network}",

year = "2016",

month = jun,

day = "21",

doi = "10.7554/eLife.15266.001",

language = "English",

volume = "5",

pages = "1--44",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications Ltd",

number = "JUN2016",

}

Busby, GBJ, Band, G, Le, QS, Jallow, M, Bougama, E, Mangano, VD, Amenga-Etego, LN, Enimil, A, Apinjoh, TO, Ndila, CM, Manjurano, A, Nyirongo, V, Doumba, O, Rockett, KA, Kwiatkowski, DP, Spencer, CCA, Vanderwal, A, Elzein, A, Nyika, A, Mendy, A, Miles, A, Diss, A, Kerasidou, A, Green, A, Jeffreys, AE, MacInnis, B, Hughes, C, Moyes, C, Hubbart, C, Malangone, C, Potter, C, Mead, D, Barnwell, D, Jyothi, D, Drury, E, Somaskantharajah, E, Hilton, E, Leffler, E, Maslen, G, Busby, G, Clarke, GM, Ragoussis, I, Garcia, JA, Rogers, J, deVries, J, Shelton, JMG, Ragoussis, J, Stalker, J, Rodford, J, O'Brien, J, Evans, J, Rowlands, K, Cook, K, Fitzpatrick, K, Kivinen, K, Small, K, Johnson, KJ, Hart, L, Manske, M, McCreight, M, Stevens, M, Pirinen, M, Hennsman, M, Parker, M, SanJoaquin, M, Seplúveda, N, Cook, O, Miotto, O, Deloukas, P, Craik, R, Wrigley, R, Watson, R, Pearson, RD, Hutton, R, Oyola, S, Auburn, S, Shah, S, Le, SQ, Molloy, S, Bull, S, Campino, S, Clark, TG, Ruano-Rubio, V, Cornelius, V, Teo, YY, Corran, P, Silva, N, Risley, P, Doyle, A, Evans, J, Horstmann, R, Plowe, C, Duffy, P, Carucci, D, Gottleib, M, Tall, A, Ly, AB, Dolo, A, Sakuntabhai, A, Puijalon, O, Bah, A, Camara, A, Sadiq, A, Abie Khan, A, Jobarteh, A, Mendy, A, Ebonyi, A, Danso, B, Taal, B, Casals-Pascual, C, Conway, DJ, Onykwelu, E, Sisay-Joof, F, Sirugo, G, Kanyi, H, Njie, H, Obu, H, Saine, H, Sambou, I, Abubakar, I, Njie, J, Jaiteh, J, Bojang, KA, Jammeh, K, Sabally-Ceesay, K, Manneh, L, Camara, L, Yamoah, L, Njie, M, Pinder, M, Jallow, M, Aiyegbo, M, Jasseh, M, Keita, ML, Saidy-Khan, M, Ceesay, N, Rasheed, O, Ceesay, PL, Esangbedo, P, Cole-Ceesay, R, Olaosebikan, R, Correa, S, Njie, S, Usen, S, Dibba, Y, Barry, A, Djimdé, A, Sall, AH, Abathina, A, Niangaly, A, Dembele, A, Poudiougou, B, Diarra, E, Bamba, K, Thera, MA, Doumbo, O, Toure, O, Konate, S, Sissoko, S, Diakite, M, Konate, AT, Modiano, D, Bougouma, EC, Bancone, G, Ouedraogo, IN, Simpore, J, Sirima, SB, Troye-Blomberg, M, Oduro, AR, Hodgson, AVO, Ghansah, A, Nkrumah, F, Atuguba, F, Koram, KA, Wilson, MD, Ansah, NA, Mensah, N, Ansah, PA, Anyorigiya, T, Asoala, V, Rogers, WO, Akoto, AO, Ofori, AO, Ansong, D, Sambian, D, Asafo-Agyei, E, Sylverken, J, Antwi, S, Agbenyega, T, Orimadegun, AE, Amodu, FA, Oni, O, Omotade, OO, Amodu, O, Olaniyan, S, Ndi, A, Yafi, C, Achidi, EA, Mbunwe, E, Anchang-Kimbi, J, Mugri, R, Besingi, R, Apinjoh, TO, Titanji, V, Elhassan, A, Hussein, A, Mohamed, H, Elhassan, I, Ibrahim, M, Kokwaro, G, Oluoch, T, Macharia, A, Newton, C, Opi, DH, Kamuya, D, Bauni, E, Marsh, K, Peshu, N, Molyneux, S, Uyoga, S, Williams, TN, Marsh, V, Nadjm, B, Maxwell, C, Drakeley, C, Riley, E, Mtei, F, Mtove, G, Wangai, H, Reyburn, H, Joseph, S, Ishengoma, D, Lemnge, M, Mutabingwa, T, Makani, J, Cox, S, Phiri, A, Munthali, A, Kachala, D, Njiragoma, L, Molyneux, ME, Moore, M, Ntunthama, N, Pensulo, P, Taylor, T, Carter, R, Fernando, D, Karunaweera, N, Dewasurendra, R, Suriyaphol, P & Malaria Genomic Epidemiology Network 2016, 'Admixture into and within sub-Saharan Africa', eLife, vol. 5, no. JUN2016, e15266, pp. 1-44. https://doi.org/10.7554/eLife.15266.001

TY - JOUR

T1 - Admixture into and within sub-Saharan Africa

AU - Busby, George B.J.

AU - Band, Gavin

AU - Le, Quang Si

AU - Jallow, Muminatou

AU - Bougama, Edith

AU - Mangano, Valentina D.

AU - Amenga-Etego, Lucas N.

AU - Enimil, Anthony

AU - Apinjoh, Tobias O.

AU - Ndila, Carolyne M.

AU - Manjurano, Alphaxard

AU - Nyirongo, Vysaul

AU - Doumba, Ogobara

AU - Rockett, Kirk A.

AU - Kwiatkowski, Dominic P.

AU - Spencer, Chris C.A.

AU - Vanderwal, Aaron

AU - Elzein, Abier

AU - Nyika, Aceme

AU - Mendy, Alieu

AU - Miles, Alistair

AU - Diss, Andrea

AU - Kerasidou, Angeliki

AU - Green, Angie

AU - Jeffreys, Anna E.

AU - MacInnis, Bronwyn

AU - Hughes, Catherine

AU - Moyes, Catherine

AU - Hubbart, Christina

AU - Malangone, Cinzia

AU - Potter, Claire

AU - Mead, Daniel

AU - Barnwell, David

AU - Jyothi, Dushyanth

AU - Drury, Eleanor

AU - Somaskantharajah, Elilan

AU - Hilton, Eliza

AU - Leffler, Ellen

AU - Maslen, Gareth

AU - Busby, George

AU - Clarke, Geraldine M

AU - Ragoussis, Ioannis

AU - Garcia, Jacob Almagro

AU - Rogers, Jane

AU - deVries, Jantina

AU - Shelton, Jennifer M G

AU - Ragoussis, Jiannis

AU - Stalker, Jim

AU - Rodford, Joanne

AU - O'Brien, John

AU - Evans, Julie

AU - Rowlands, Kate

AU - Cook, Katharine

AU - Fitzpatrick, Kathryn

AU - Kivinen, Katja

AU - Small, Kerrin

AU - Johnson, Kimberly J.

AU - Hart, Lee

AU - Manske, Magnus

AU - McCreight, Marilyn

AU - Stevens, Marryat

AU - Pirinen, Matti

AU - Hennsman, Meike

AU - Parker, Michael

AU - SanJoaquin, Miguel

AU - Seplúveda, Nuno

AU - Cook, Olivia

AU - Miotto, Olivo

AU - Deloukas, Panos

AU - Craik, Rachel

AU - Wrigley, Rebecca

AU - Watson, Renee

AU - Pearson, Richard D

AU - Hutton, Robert

AU - Oyola, Samuel

AU - Auburn, Sarah

AU - Shah, Shivang

AU - Le, Si Quang

AU - Molloy, Sile

AU - Bull, Susan

AU - Campino, Susana

AU - Clark, Taane G.

AU - Ruano-Rubio, Valentín

AU - Cornelius, Victoria

AU - Teo, Yik Ying

AU - Corran, Patrick

AU - Silva, Nilupa

AU - Risley, Paul

AU - Doyle, Alan

AU - Evans, Jennifer

AU - Horstmann, Rolf

AU - Plowe, Chris

AU - Duffy, Patrick

AU - Carucci, Dan

AU - Gottleib, Michael

AU - Tall, Adama

AU - Ly, Alioune Badara

AU - Dolo, Amagana

AU - Sakuntabhai, Anavaj

AU - Puijalon, Odile

AU - Bah, Abdou

AU - Camara, Abdoulie

AU - Sadiq, Abubacar

AU - Abie Khan, Aja

AU - Jobarteh, Amie

AU - Mendy, Anthony

AU - Ebonyi, Augustine

AU - Danso, Bakary

AU - Taal, Bintou

AU - Casals-Pascual, Climent

AU - Conway, David J.

AU - Onykwelu, Emmanuel

AU - Sisay-Joof, Fatoumatta

AU - Sirugo, Giorgio

AU - Kanyi, Haddy

AU - Njie, Haddy

AU - Obu, Herbert

AU - Saine, Horeja

AU - Sambou, Idrissa

AU - Abubakar, Ismaela

AU - Njie, Jalimory

AU - Jaiteh, Jula

AU - Bojang, Kalifa A.

AU - Jammeh, Kebba

AU - Sabally-Ceesay, Kumba

AU - Manneh, Lamin

AU - Camara, Landing

AU - Yamoah, Lawrence

AU - Njie, Madi

AU - Pinder, Margaret

AU - Jallow, Mariatou

AU - Aiyegbo, Mohammed

AU - Jasseh, Momodou

AU - Keita, Momodou Lamin

AU - Saidy-Khan, Momodou

AU - Ceesay, Ndey

AU - Rasheed, Oba

AU - Ceesay, Pa Lamin

AU - Esangbedo, Pamela

AU - Cole-Ceesay, Ramou

AU - Olaosebikan, Rasaq

AU - Correa, Simon

AU - Njie, Sophie

AU - Usen, Stanley

AU - Dibba, Yaya

AU - Barry, Abdoulaye

AU - Djimdé, A.

AU - Sall, Abdourahmane H.

AU - Abathina, Amadou

AU - Niangaly, Amadou

AU - Dembele, Awa

AU - Poudiougou, Belco

AU - Diarra, Elizabeth

AU - Bamba, Kariatou

AU - Thera, Mahamadou A.

AU - Doumbo, Ogobara

AU - Toure, Ousmane

AU - Konate, Salimata

AU - Sissoko, Sibiry

AU - Diakite, Mahamadou

AU - Konate, Amadou T.

AU - Modiano, David

AU - Bougouma, Edith C.

AU - Bancone, Germana

AU - Ouedraogo, Issa N.

AU - Simpore, Jaques

AU - Sirima, Sodiomon B.

AU - Troye-Blomberg, Marita

AU - Oduro, Abraham R.

AU - Hodgson, Abraham V.O.

AU - Ghansah, Anita

AU - Nkrumah, Francis

AU - Atuguba, Frank

AU - Koram, Kwadwo A.

AU - Wilson, Michael D.

AU - Ansah, Nana Akosua

AU - Mensah, Nathan

AU - Ansah, Patrick A.

AU - Anyorigiya, Thomas

AU - Asoala, Victor

AU - Rogers, William O.

AU - Akoto, Alex Osei

AU - Ofori, Alex Owusu

AU - Ansong, Daniel

AU - Sambian, David

AU - Asafo-Agyei, Emmanuel

AU - Sylverken, Justice

AU - Antwi, Sampson

AU - Agbenyega, Tsiri

AU - Orimadegun, Adebola E.

AU - Amodu, Folakemi Anjol

AU - Oni, Olajumoke

AU - Omotade, Olayemi O.

AU - Amodu, Olukemi

AU - Olaniyan, Subulade

AU - Ndi, Andre

AU - Yafi, Clarisse

AU - Achidi, Eric Akum

AU - Mbunwe, Eric

AU - Anchang-Kimbi, Judith

AU - Mugri, Regina

AU - Besingi, Richard

AU - Apinjoh, Tobias O.

AU - Titanji, Vincent

AU - Elhassan, Ahmed

AU - Hussein, Ayman

AU - Mohamed, Hiba

AU - Elhassan, Ibrahim

AU - Ibrahim, Muntaser

AU - Kokwaro, Gilbert

AU - Oluoch, Tom

AU - Macharia, Alexander

AU - Newton, Charles

AU - Opi, Daniel H.

AU - Kamuya, Dorcas

AU - Bauni, Evasius

AU - Marsh, Kevin

AU - Peshu, Norbert

AU - Molyneux, Sassy

AU - Uyoga, Sophie

AU - Williams, Thomas N

AU - Marsh, Vicki

AU - Nadjm, Behzad

AU - Maxwell, Caroline

AU - Drakeley, Chris

AU - Riley, Eleanor

AU - Mtei, Frank

AU - Mtove, George

AU - Wangai, Hannah

AU - Reyburn, Hugh

AU - Joseph, Sarah

AU - Ishengoma, Deus

AU - Lemnge, Martha

AU - Mutabingwa, Theonest

AU - Makani, Julie

AU - Cox, Sharon

AU - Phiri, Ajib

AU - Munthali, Annie

AU - Kachala, David

AU - Njiragoma, Labes

AU - Molyneux, Malcolm E.

AU - Moore, Mike

AU - Ntunthama, Neema

AU - Pensulo, Paul

AU - Taylor, Terrie

AU - Carter, Richard

AU - Fernando, Deepika

AU - Karunaweera, Nadira

AU - Dewasurendra, Rajika

AU - Suriyaphol, Prapat

AU - Malaria Genomic Epidemiology Network

PY - 2016/6/21

Y1 - 2016/6/21

N2 - Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.

AB - Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.

UR - http://www.scopus.com/inward/record.url?scp=84975491862&partnerID=8YFLogxK

U2 - 10.7554/eLife.15266.001

DO - 10.7554/eLife.15266.001

M3 - Article

SN - 2050-084X

VL - 5

SP - 1

EP - 44

JO - eLife

JF - eLife

IS - JUN2016

M1 - e15266

ER -

Admixture into and within sub-Saharan Africa

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