Advances and remaining uncertainties in the epidemiology of Burkholderia pseudomallei and melioidosis

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Major advances have been made in molecular studies of Burkholderia pseudomallei and the immunology of melioidosis. However, there remain large gaps in understanding of the epidemiology of this enigmatic disease. Identified global distribution boundaries of melioidosis continue to expand. Recent data suggest Australian strains of B. pseudomallei may be ancestral to those from Southeast Asia, but the ecology of this environmental bacterium remains elusive. Despite the potential for rapidly progressive septicaemia, the critical virulence factors in B. pseudomallei remain to be clarified. Inhalation following aerosolization of B. pseudomallei may account for the high mortality when melioidosis occurs after severe weather events. � 2007 Royal Society of Tropical Medicine and Hygiene.
    Original languageEnglish
    Pages (from-to)225-227
    Number of pages3
    JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
    Volume102
    Issue number3
    Publication statusPublished - 2008

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    Melioidosis
    Burkholderia pseudomallei
    Uncertainty
    Epidemiology
    Tropical Medicine
    Southeastern Asia
    Weather
    Virulence Factors
    Allergy and Immunology
    Ecology
    Hygiene
    Inhalation
    Sepsis
    Bacteria
    Mortality

    Cite this

    @article{05d0c8f96c75463fb2616012cdb50754,
    title = "Advances and remaining uncertainties in the epidemiology of Burkholderia pseudomallei and melioidosis",
    abstract = "Major advances have been made in molecular studies of Burkholderia pseudomallei and the immunology of melioidosis. However, there remain large gaps in understanding of the epidemiology of this enigmatic disease. Identified global distribution boundaries of melioidosis continue to expand. Recent data suggest Australian strains of B. pseudomallei may be ancestral to those from Southeast Asia, but the ecology of this environmental bacterium remains elusive. Despite the potential for rapidly progressive septicaemia, the critical virulence factors in B. pseudomallei remain to be clarified. Inhalation following aerosolization of B. pseudomallei may account for the high mortality when melioidosis occurs after severe weather events. � 2007 Royal Society of Tropical Medicine and Hygiene.",
    keywords = "aerosol, Australia, bacterial strain, bacterial virulence, Burkholderia pseudomallei, disease severity, environmental factor, human, immunology, melioidosis, molecular dynamics, mortality, nonhuman, review, risk factor, septicemia, Southeast Asia, weather, Humans, Melioidosis, Virulence, Virulence Factors, Bacteria (microorganisms)",
    author = "Bart Currie",
    year = "2008",
    language = "English",
    volume = "102",
    pages = "225--227",
    journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",
    issn = "0035-9203",
    publisher = "Elsevier",
    number = "3",

    }

    Advances and remaining uncertainties in the epidemiology of Burkholderia pseudomallei and melioidosis. / Currie, Bart.

    In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 102, No. 3, 2008, p. 225-227.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Advances and remaining uncertainties in the epidemiology of Burkholderia pseudomallei and melioidosis

    AU - Currie, Bart

    PY - 2008

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    N2 - Major advances have been made in molecular studies of Burkholderia pseudomallei and the immunology of melioidosis. However, there remain large gaps in understanding of the epidemiology of this enigmatic disease. Identified global distribution boundaries of melioidosis continue to expand. Recent data suggest Australian strains of B. pseudomallei may be ancestral to those from Southeast Asia, but the ecology of this environmental bacterium remains elusive. Despite the potential for rapidly progressive septicaemia, the critical virulence factors in B. pseudomallei remain to be clarified. Inhalation following aerosolization of B. pseudomallei may account for the high mortality when melioidosis occurs after severe weather events. � 2007 Royal Society of Tropical Medicine and Hygiene.

    AB - Major advances have been made in molecular studies of Burkholderia pseudomallei and the immunology of melioidosis. However, there remain large gaps in understanding of the epidemiology of this enigmatic disease. Identified global distribution boundaries of melioidosis continue to expand. Recent data suggest Australian strains of B. pseudomallei may be ancestral to those from Southeast Asia, but the ecology of this environmental bacterium remains elusive. Despite the potential for rapidly progressive septicaemia, the critical virulence factors in B. pseudomallei remain to be clarified. Inhalation following aerosolization of B. pseudomallei may account for the high mortality when melioidosis occurs after severe weather events. � 2007 Royal Society of Tropical Medicine and Hygiene.

    KW - aerosol

    KW - Australia

    KW - bacterial strain

    KW - bacterial virulence

    KW - Burkholderia pseudomallei

    KW - disease severity

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    KW - human

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    KW - molecular dynamics

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    KW - nonhuman

    KW - review

    KW - risk factor

    KW - septicemia

    KW - Southeast Asia

    KW - weather

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    KW - Virulence

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    KW - Bacteria (microorganisms)

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