Advances and remaining uncertainties in the epidemiology of Burkholderia pseudomallei and melioidosis

    Research output: Contribution to journalArticle

    Abstract

    Major advances have been made in molecular studies of Burkholderia pseudomallei and the immunology of melioidosis. However, there remain large gaps in understanding of the epidemiology of this enigmatic disease. Identified global distribution boundaries of melioidosis continue to expand. Recent data suggest Australian strains of B. pseudomallei may be ancestral to those from Southeast Asia, but the ecology of this environmental bacterium remains elusive. Despite the potential for rapidly progressive septicaemia, the critical virulence factors in B. pseudomallei remain to be clarified. Inhalation following aerosolization of B. pseudomallei may account for the high mortality when melioidosis occurs after severe weather events. � 2007 Royal Society of Tropical Medicine and Hygiene.
    Original languageEnglish
    Pages (from-to)225-227
    Number of pages3
    JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
    Volume102
    Issue number3
    Publication statusPublished - 2008

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