@article{00f2cfce696a4a5680ba5202deddce89,
title = "Advances in the Diagnosis and Management of Central Venous Access Device Infections in Children",
abstract = "Infection is a well-known complication of central venous access device (CVAD) use, with an incidence of 3-6 bloodstream infections per 1,000 catheter days in children. Prevention of CVAD infections has improved with new strategies including the use of chlorhexidine antisepsis, bundles, maximal sterile barriers for insertion, prophylactic locks, antibiotic impregnated catheters and tunnelling of long-term devices. Despite these strategies, catheter-related bloodstream infections (CRBSIs) continue to be an important health problem. New approaches to diagnosis include differential time to positivity and quantification of blood cultures and molecular diagnostics. The management of CRBSIs includes techniques for line salvage including ethanol, antibiotic, hydrochloric acid, taurolidine and urokinase locks. When these fail, line removal and antimicrobial therapy are recommended. ",
keywords = "alcohol, amikacin, amphotericin B, ampicillin, antibiotic agent, ceftazidime, citric acid, edetic acid, heparin, hydrochloric acid, linezolid, taurolidine citrate, teicoplanin, unclassified drug, urokinase, vancomycin, article, bacterium contamination, bacterium identification, blood culture, Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, catheter infection, central venous catheter, child, colony forming unit, device infection, device removal, disease association, drug choice, drug potentiation, Enterobacter, Escherichia coli, human, infection complication, infection prevention, infection risk, intermethod comparison, Klebsiella, medical decision making, molecular diagnosis, molecular pathology, nonhuman, predictive value, prevalence, priority journal, Pseudomonas aeruginosa, quality control, risk assessment, risk factor, salvage therapy, Staphylococcus aureus, Streptococcus, thrombosis, thrombosis prevention, treatment planning, bacterial infection, central venous catheterization, infection control, methodology, review, Bacterial Infections, Catheterization, Central Venous, Child, Humans, Infection Control",
author = "Asha Bowan and Jonathan Carapetis",
year = "2011",
doi = "10.1007/978-1-4419-7185-2_8",
language = "English",
volume = "2011",
pages = "91--106",
journal = "Advances in Experimental Medicine and Biology",
issn = "0065-2598",
publisher = "Springer",
number = "697",
}