Advances in the Diagnosis and Management of Central Venous Access Device Infections in Children

Asha Bowan; Jonathan Carapetis

doi:10.1007/978-1-4419-7185-2_8

Advances in the Diagnosis and Management of Central Venous Access Device Infections in Children

Asha Bowan, Jonathan Carapetis

Research output: Contribution to journal › Article

Abstract

Infection is a well-known complication of central venous access device (CVAD) use, with an incidence of 3-6 bloodstream infections per 1,000 catheter days in children. Prevention of CVAD infections has improved with new strategies including the use of chlorhexidine antisepsis, bundles, maximal sterile barriers for insertion, prophylactic locks, antibiotic impregnated catheters and tunnelling of long-term devices. Despite these strategies, catheter-related bloodstream infections (CRBSIs) continue to be an important health problem. New approaches to diagnosis include differential time to positivity and quantification of blood cultures and molecular diagnostics. The management of CRBSIs includes techniques for line salvage including ethanol, antibiotic, hydrochloric acid, taurolidine and urokinase locks. When these fail, line removal and antimicrobial therapy are recommended.

Original language	English
Pages (from-to)	91-106
Number of pages	16
Journal	Advances in Experimental Medicine and Biology
Volume	2011
Issue number	697
DOIs	https://doi.org/10.1007/978-1-4419-7185-2_8
Publication status	Published - 2011

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Bowan, A., & Carapetis, J. (2011). Advances in the Diagnosis and Management of Central Venous Access Device Infections in Children. Advances in Experimental Medicine and Biology, 2011(697), 91-106. https://doi.org/10.1007/978-1-4419-7185-2_8

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abstract = "Infection is a well-known complication of central venous access device (CVAD) use, with an incidence of 3-6 bloodstream infections per 1,000 catheter days in children. Prevention of CVAD infections has improved with new strategies including the use of chlorhexidine antisepsis, bundles, maximal sterile barriers for insertion, prophylactic locks, antibiotic impregnated catheters and tunnelling of long-term devices. Despite these strategies, catheter-related bloodstream infections (CRBSIs) continue to be an important health problem. New approaches to diagnosis include differential time to positivity and quantification of blood cultures and molecular diagnostics. The management of CRBSIs includes techniques for line salvage including ethanol, antibiotic, hydrochloric acid, taurolidine and urokinase locks. When these fail, line removal and antimicrobial therapy are recommended. ",

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author = "Asha Bowan and Jonathan Carapetis",

year = "2011",

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