Aerobic training mitigates the negative impact of diabetes on fertility

Abbas Saremi; Zahra Yousefvand; Mohammad Parastesh; Mohammad Bayat; Daniel Gahreman

doi:10.1111/and.14306

Aerobic training mitigates the negative impact of diabetes on fertility

Abbas Saremi, Zahra Yousefvand, Mohammad Parastesh, Mohammad Bayat, Daniel Gahreman

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Abstract

Diabetes negatively affects the reproductive system. This present study investigated the effects of aerobic training on protamine 1 and 2 mRNA expression, sex hormones, antioxidant defence and sperm quality in diabetic rats. Thirty-six male Wistar rats were randomly allocated into three groups including diabetic training (DT) group, diabetic (D) group and control (C) group. Rats in DT were exercised 5 times per week for 8 weeks. Blood samples were collected for evaluation of sex hormones 48 h after the last training session. Also, the testes were removed and subjected to histological evaluation and semen analysis. Testicular mRNA expressions of protamines were determined by RT-qPCR. Protamines 1 and 2, and the ratio of protamine 1 to protamine 2 were significantly lower in DT and D groups compared with C group (p < 0.01). LH and testosterone levels were significantly lower in D group compared with DT and C group (p < 0.01). Malondialdehyde was significantly lower in DT and C groups compared with D group (p < 0.001). Sperm parameters were significantly lower in D group compared with C group (p < 0.01). Our findings suggest that aerobic training may mitigate the negative impact of diabetes on sex hormones, oxidative stress, protamine content and sperm parameters in male rats.

Original language	English
Article number	e14306
Pages (from-to)	1-9
Number of pages	9
Journal	Andrologia
Volume	54
Issue number	1
Early online date	Nov 2021
DOIs	https://doi.org/10.1111/and.14306
Publication status	Published - Feb 2022

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title = "Aerobic training mitigates the negative impact of diabetes on fertility",

abstract = "Diabetes negatively affects the reproductive system. This present study investigated the effects of aerobic training on protamine 1 and 2 mRNA expression, sex hormones, antioxidant defence and sperm quality in diabetic rats. Thirty-six male Wistar rats were randomly allocated into three groups including diabetic training (DT) group, diabetic (D) group and control (C) group. Rats in DT were exercised 5 times per week for 8 weeks. Blood samples were collected for evaluation of sex hormones 48 h after the last training session. Also, the testes were removed and subjected to histological evaluation and semen analysis. Testicular mRNA expressions of protamines were determined by RT-qPCR. Protamines 1 and 2, and the ratio of protamine 1 to protamine 2 were significantly lower in DT and D groups compared with C group (p < 0.01). LH and testosterone levels were significantly lower in D group compared with DT and C group (p < 0.01). Malondialdehyde was significantly lower in DT and C groups compared with D group (p < 0.001). Sperm parameters were significantly lower in D group compared with C group (p < 0.01). Our findings suggest that aerobic training may mitigate the negative impact of diabetes on sex hormones, oxidative stress, protamine content and sperm parameters in male rats.",

keywords = "diabetes mellitus, exercise, infertility, malondialdehyde, protamines",

author = "Abbas Saremi and Zahra Yousefvand and Mohammad Parastesh and Mohammad Bayat and Daniel Gahreman",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH Copyright: Copyright 2021 Elsevier B.V., All rights reserved. Funding Information: This paper was extracted from the MSc thesis written by Zahra Yousefvand. The present research was extracted from a project approved by the Deputy Director of Research and Technology at Arak University of Medical Sciences. The code of ethics is also included in the description (IR.Arakmu.rec.1398.329) in the ethics committee of the research projects of Arak University of Medical Sciences. Also, the authors would like to acknowledge everyone who assisted us during this project. Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH",

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N1 - Publisher Copyright: © 2021 Wiley-VCH GmbH Copyright: Copyright 2021 Elsevier B.V., All rights reserved. Funding Information: This paper was extracted from the MSc thesis written by Zahra Yousefvand. The present research was extracted from a project approved by the Deputy Director of Research and Technology at Arak University of Medical Sciences. The code of ethics is also included in the description (IR.Arakmu.rec.1398.329) in the ethics committee of the research projects of Arak University of Medical Sciences. Also, the authors would like to acknowledge everyone who assisted us during this project. Publisher Copyright: © 2021 Wiley-VCH GmbH

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Aerobic training mitigates the negative impact of diabetes on fertility

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