Aerobic training mitigates the negative impact of diabetes on fertility

Abbas Saremi, Zahra Yousefvand, Mohammad Parastesh, Mohammad Bayat, Daniel Gahreman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Diabetes negatively affects the reproductive system. This present study investigated the effects of aerobic training on protamine 1 and 2 mRNA expression, sex hormones, antioxidant defence and sperm quality in diabetic rats. Thirty-six male Wistar rats were randomly allocated into three groups including diabetic training (DT) group, diabetic (D) group and control (C) group. Rats in DT were exercised 5 times per week for 8 weeks. Blood samples were collected for evaluation of sex hormones 48 h after the last training session. Also, the testes were removed and subjected to histological evaluation and semen analysis. Testicular mRNA expressions of protamines were determined by RT-qPCR. Protamines 1 and 2, and the ratio of protamine 1 to protamine 2 were significantly lower in DT and D groups compared with C group (p < 0.01). LH and testosterone levels were significantly lower in D group compared with DT and C group (p < 0.01). Malondialdehyde was significantly lower in DT and C groups compared with D group (p < 0.001). Sperm parameters were significantly lower in D group compared with C group (p < 0.01). Our findings suggest that aerobic training may mitigate the negative impact of diabetes on sex hormones, oxidative stress, protamine content and sperm parameters in male rats.

    Original languageEnglish
    Article numbere14306
    Pages (from-to)1-9
    Number of pages9
    JournalAndrologia
    Volume54
    Issue number1
    Early online dateNov 2021
    DOIs
    Publication statusPublished - Feb 2022

    Fingerprint

    Dive into the research topics of 'Aerobic training mitigates the negative impact of diabetes on fertility'. Together they form a unique fingerprint.

    Cite this