Age-specific cluster of cases of serotype 1 Streptococcus pneumoniae carriage in remote Indigenous communities in Australia

Heidi Smith-Vaughan, Robyn Marsh, Grant Mackenzie, J Fisher, Peter Morris, Kim Hare, G McCallum, Michael Binks, D Murphy, G LUM, H COOK, V KRAUSE, Susan Jacups, Amanda Leach

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Seven-valent pneumococcal conjugate vaccination commenced in 2001 for Australian indigenous infants. Pneumococcal carriage surveillance detected substantial replacement with nonvaccine serotypes and a cluster of serotype 1 carriage. Our aim was to review Streptococcus pneumoniae serotype 1 carriage and invasive pneumococcal disease (IPD) data for this population and to analyze serotype 1 isolates. Carriage data were collected between 1992 and 2004 in the Darwin region, one of the five regions in the Northern Territory. Carriage data were also collected in 2003 and 2005 from four regions in the Northern Territory. Twenty-six cases of serotype 1 IPD were reported from 1994 to 2007 in the Northern Territory. Forty-four isolates were analyzed by BOX typing and 11 by multilocus sequence typing. In the Darwin region, 26 children were reported carrying serotype 1 (ST227) in 2002 but not during later surveillance. Scattered cases of serotype 1 carriage were noted in two other regions. Cocolonization of serotype 1 with other pneumococcal serotypes was common (34% serotype 1-positive swabs). In conclusion, pneumococcal carriage studies detected intermittent serotype 1 carriage and an ST227 cluster in children in indigenous communities in the Northern Territory of Australia. There was no apparent increase in serotype 1 IPD during this time. The rate of serotype 1 cocolonization with other pneumococcal serotypes suggests that carriage of this serotype may be underestimated. Copyright � 2009, American Society for Microbiology. All Rights Reserved.
    Original languageEnglish
    Pages (from-to)218-221
    Number of pages4
    JournalClinical and Vaccine Immunology
    Volume16
    Issue number2
    Publication statusPublished - 2009

    Fingerprint

    Streptococcus pneumoniae
    Microbiology
    Northern Territory
    Serogroup
    Multilocus Sequence Typing
    Vaccination

    Cite this

    Smith-Vaughan, Heidi ; Marsh, Robyn ; Mackenzie, Grant ; Fisher, J ; Morris, Peter ; Hare, Kim ; McCallum, G ; Binks, Michael ; Murphy, D ; LUM, G ; COOK, H ; KRAUSE, V ; Jacups, Susan ; Leach, Amanda. / Age-specific cluster of cases of serotype 1 Streptococcus pneumoniae carriage in remote Indigenous communities in Australia. In: Clinical and Vaccine Immunology. 2009 ; Vol. 16, No. 2. pp. 218-221.
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    title = "Age-specific cluster of cases of serotype 1 Streptococcus pneumoniae carriage in remote Indigenous communities in Australia",
    abstract = "Seven-valent pneumococcal conjugate vaccination commenced in 2001 for Australian indigenous infants. Pneumococcal carriage surveillance detected substantial replacement with nonvaccine serotypes and a cluster of serotype 1 carriage. Our aim was to review Streptococcus pneumoniae serotype 1 carriage and invasive pneumococcal disease (IPD) data for this population and to analyze serotype 1 isolates. Carriage data were collected between 1992 and 2004 in the Darwin region, one of the five regions in the Northern Territory. Carriage data were also collected in 2003 and 2005 from four regions in the Northern Territory. Twenty-six cases of serotype 1 IPD were reported from 1994 to 2007 in the Northern Territory. Forty-four isolates were analyzed by BOX typing and 11 by multilocus sequence typing. In the Darwin region, 26 children were reported carrying serotype 1 (ST227) in 2002 but not during later surveillance. Scattered cases of serotype 1 carriage were noted in two other regions. Cocolonization of serotype 1 with other pneumococcal serotypes was common (34{\%} serotype 1-positive swabs). In conclusion, pneumococcal carriage studies detected intermittent serotype 1 carriage and an ST227 cluster in children in indigenous communities in the Northern Territory of Australia. There was no apparent increase in serotype 1 IPD during this time. The rate of serotype 1 cocolonization with other pneumococcal serotypes suggests that carriage of this serotype may be underestimated. Copyright � 2009, American Society for Microbiology. All Rights Reserved.",
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    author = "Heidi Smith-Vaughan and Robyn Marsh and Grant Mackenzie and J Fisher and Peter Morris and Kim Hare and G McCallum and Michael Binks and D Murphy and G LUM and H COOK and V KRAUSE and Susan Jacups and Amanda Leach",
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    Age-specific cluster of cases of serotype 1 Streptococcus pneumoniae carriage in remote Indigenous communities in Australia. / Smith-Vaughan, Heidi; Marsh, Robyn; Mackenzie, Grant; Fisher, J; Morris, Peter; Hare, Kim; McCallum, G; Binks, Michael; Murphy, D; LUM, G; COOK, H; KRAUSE, V; Jacups, Susan; Leach, Amanda.

    In: Clinical and Vaccine Immunology, Vol. 16, No. 2, 2009, p. 218-221.

    Research output: Contribution to journalArticleResearchpeer-review

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    AB - Seven-valent pneumococcal conjugate vaccination commenced in 2001 for Australian indigenous infants. Pneumococcal carriage surveillance detected substantial replacement with nonvaccine serotypes and a cluster of serotype 1 carriage. Our aim was to review Streptococcus pneumoniae serotype 1 carriage and invasive pneumococcal disease (IPD) data for this population and to analyze serotype 1 isolates. Carriage data were collected between 1992 and 2004 in the Darwin region, one of the five regions in the Northern Territory. Carriage data were also collected in 2003 and 2005 from four regions in the Northern Territory. Twenty-six cases of serotype 1 IPD were reported from 1994 to 2007 in the Northern Territory. Forty-four isolates were analyzed by BOX typing and 11 by multilocus sequence typing. In the Darwin region, 26 children were reported carrying serotype 1 (ST227) in 2002 but not during later surveillance. Scattered cases of serotype 1 carriage were noted in two other regions. Cocolonization of serotype 1 with other pneumococcal serotypes was common (34% serotype 1-positive swabs). In conclusion, pneumococcal carriage studies detected intermittent serotype 1 carriage and an ST227 cluster in children in indigenous communities in the Northern Territory of Australia. There was no apparent increase in serotype 1 IPD during this time. The rate of serotype 1 cocolonization with other pneumococcal serotypes suggests that carriage of this serotype may be underestimated. Copyright � 2009, American Society for Microbiology. All Rights Reserved.

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