Aim: To evaluate Tag Team Patient Safety Simulation in managing, resourcing, and scale simulation learning with large student cohorts. Method: The Tag Team Patient Safety Simulation method was used in three scenarios in a cohort of (N = 392) year 3 nursing students. The experience was evaluated using the Satisfaction with Simulation Experience Scale and analyzed with descriptive statistics. Students also provided qualitative comment. Findings: The process of Tag Team Patient Safety Simulation was effective in creating engagement with high satisfaction in all elements of the experience. Discussion: Students found the process supported a positive learning environment, was straightforward and easy. Some students felt a smaller team allocated to tag into and out of the action would have enabled a greater opportunity to participate. Conclusion: Tag Team Patient Safety Simulation is a technique suitable to create active engagement with nursing students in simulation designed to test clinical reasoning and critical thinking.