TY - JOUR
T1 - Analgesic activities of synthesized divalent metal complexes of tolfenamic acid
AU - Mazumder, Md Mahabob Ullah
AU - Sukul, Abhijit
AU - Saha, Sajal Kumar
N1 - Publisher Copyright:
© 2016, University of Dhaka. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2016/8
Y1 - 2016/8
N2 - The objective of the study was to synthesize and to uncover the potentially interesting biological peripheral and central analgesic activities of some new divalent metal complexes of tolfenamic acid. The inception of the study was carried out with the formation of complexes [Cu(tolf)2(H2O)]2, [Co(tolf)2(H2O)2] and [Zn(tolf)2(H2O)] through the reaction of tolfenamic acid, a potent anti-inflammatory drug, with Cu, Co and Zn salts. Characterization of the metal complexes of tolfenamic acid was furnished with spectral (FTIR, UV-Visible) and calorimetric (DSC) analysis. The peripheral analgesic activities of the complexes were investigated by acetic acid-induced writhing method. In peripheral analgesia model, Cu, Co and Zn complexes of tolfenamic acid showed significantly promising analgesic potency at a dose of 25 mg/kg body weight with percentage of inhibition of acetic acid induced writhing by 49.67% (p < 0.01), 67.32% (p < 0.001) and 72.55% (p < 0.001), respectively compared to the standard tolfenamic acid 46.41%. Radiant heat tail-flick test was used to observe the central analgesic activity which showed analgesic effect evidenced by % elongation time (34.59%, 25.34% and 53.08%), respectively compared to that of morphine 2 mg/kg body weight at an equimolar dose of tolfenamic acid at 10 mg/kg body weight after 30 minutes. In the final analysis, it can be stipulated that newly synthesized stable metal complexes of tolfenamic acid have promising pharmacological effects like peripheral and central analgesic potency. Therefore, these complexes may be the better therapeutic options in the near future however it needs further extensive analysis in the pharmacokinetics, pharmacodynamics and toxicology perspective.
AB - The objective of the study was to synthesize and to uncover the potentially interesting biological peripheral and central analgesic activities of some new divalent metal complexes of tolfenamic acid. The inception of the study was carried out with the formation of complexes [Cu(tolf)2(H2O)]2, [Co(tolf)2(H2O)2] and [Zn(tolf)2(H2O)] through the reaction of tolfenamic acid, a potent anti-inflammatory drug, with Cu, Co and Zn salts. Characterization of the metal complexes of tolfenamic acid was furnished with spectral (FTIR, UV-Visible) and calorimetric (DSC) analysis. The peripheral analgesic activities of the complexes were investigated by acetic acid-induced writhing method. In peripheral analgesia model, Cu, Co and Zn complexes of tolfenamic acid showed significantly promising analgesic potency at a dose of 25 mg/kg body weight with percentage of inhibition of acetic acid induced writhing by 49.67% (p < 0.01), 67.32% (p < 0.001) and 72.55% (p < 0.001), respectively compared to the standard tolfenamic acid 46.41%. Radiant heat tail-flick test was used to observe the central analgesic activity which showed analgesic effect evidenced by % elongation time (34.59%, 25.34% and 53.08%), respectively compared to that of morphine 2 mg/kg body weight at an equimolar dose of tolfenamic acid at 10 mg/kg body weight after 30 minutes. In the final analysis, it can be stipulated that newly synthesized stable metal complexes of tolfenamic acid have promising pharmacological effects like peripheral and central analgesic potency. Therefore, these complexes may be the better therapeutic options in the near future however it needs further extensive analysis in the pharmacokinetics, pharmacodynamics and toxicology perspective.
KW - Characterization and analgesic activity
KW - Metal complex
KW - Tolfenamic acid
UR - http://www.scopus.com/inward/record.url?scp=84983059074&partnerID=8YFLogxK
U2 - 10.3329/dujps.v15i1.29202
DO - 10.3329/dujps.v15i1.29202
M3 - Article
AN - SCOPUS:84983059074
VL - 15
SP - 89
EP - 96
JO - Dhaka University Journal of Pharmaceutical Sciences
JF - Dhaka University Journal of Pharmaceutical Sciences
SN - 1816-1820
IS - 1
ER -