Anatomy and Neurophysiology of Cough

CHEST Guideline and Expert Panel Report

Brendan J. Canning, Anne B. Chang, Donald C. Bolser, Jaclyn A. Smith, Stuart B. Mazzone, Lorcan McGarvey, CHEST Expert Cough Panel

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminate primarily in the larynx, trachea, carina, and large intrapulmonary bronchi. Other bronchopulmonary sensory nerves, sensory nerves innervating other viscera, as well as somatosensory nerves innervating the chest wall, diaphragm, and abdominal musculature regulate cough patterning and cough sensitivity. The responsiveness and morphology of the airway vagal sensory nerve subtypes and the extrapulmonary sensory nerves that regulate coughing are described. The brainstem and higher brain control systems that process this sensory information are complex, but our current understanding of them is considerable and increasing. The relevance of these neural systems to clinical phenomena, such as urge to cough and psychologic methods for treatment of dystussia, is high, and modern imaging methods have revealed potential neural substrates for some features of cough in the human.

    Original languageEnglish
    Pages (from-to)1633-1648
    Number of pages16
    JournalChest
    Volume146
    Issue number6
    DOIs
    Publication statusPublished - 1 Dec 2014

    Fingerprint

    Neurophysiology
    Cough
    Anatomy
    Guidelines
    Unmyelinated Nerve Fibers
    Viscera
    Thoracic Wall
    Bronchi
    Larynx
    Diaphragm
    Trachea
    Brain Stem
    Acids
    Brain

    Cite this

    Canning, B. J., Chang, A. B., Bolser, D. C., Smith, J. A., Mazzone, S. B., McGarvey, L., & CHEST Expert Cough Panel (2014). Anatomy and Neurophysiology of Cough: CHEST Guideline and Expert Panel Report. Chest, 146(6), 1633-1648. https://doi.org/10.1378/chest.14-1481
    Canning, Brendan J. ; Chang, Anne B. ; Bolser, Donald C. ; Smith, Jaclyn A. ; Mazzone, Stuart B. ; McGarvey, Lorcan ; CHEST Expert Cough Panel. / Anatomy and Neurophysiology of Cough : CHEST Guideline and Expert Panel Report. In: Chest. 2014 ; Vol. 146, No. 6. pp. 1633-1648.
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    abstract = "Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminate primarily in the larynx, trachea, carina, and large intrapulmonary bronchi. Other bronchopulmonary sensory nerves, sensory nerves innervating other viscera, as well as somatosensory nerves innervating the chest wall, diaphragm, and abdominal musculature regulate cough patterning and cough sensitivity. The responsiveness and morphology of the airway vagal sensory nerve subtypes and the extrapulmonary sensory nerves that regulate coughing are described. The brainstem and higher brain control systems that process this sensory information are complex, but our current understanding of them is considerable and increasing. The relevance of these neural systems to clinical phenomena, such as urge to cough and psychologic methods for treatment of dystussia, is high, and modern imaging methods have revealed potential neural substrates for some features of cough in the human.",
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    Canning, BJ, Chang, AB, Bolser, DC, Smith, JA, Mazzone, SB, McGarvey, L & CHEST Expert Cough Panel 2014, 'Anatomy and Neurophysiology of Cough: CHEST Guideline and Expert Panel Report', Chest, vol. 146, no. 6, pp. 1633-1648. https://doi.org/10.1378/chest.14-1481

    Anatomy and Neurophysiology of Cough : CHEST Guideline and Expert Panel Report. / Canning, Brendan J.; Chang, Anne B.; Bolser, Donald C.; Smith, Jaclyn A.; Mazzone, Stuart B.; McGarvey, Lorcan; CHEST Expert Cough Panel.

    In: Chest, Vol. 146, No. 6, 01.12.2014, p. 1633-1648.

    Research output: Contribution to journalArticleResearchpeer-review

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    AU - Chang, Anne B.

    AU - Bolser, Donald C.

    AU - Smith, Jaclyn A.

    AU - Mazzone, Stuart B.

    AU - McGarvey, Lorcan

    AU - CHEST Expert Cough Panel

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    Canning BJ, Chang AB, Bolser DC, Smith JA, Mazzone SB, McGarvey L et al. Anatomy and Neurophysiology of Cough: CHEST Guideline and Expert Panel Report. Chest. 2014 Dec 1;146(6):1633-1648. https://doi.org/10.1378/chest.14-1481