Abstract
Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminate primarily in the larynx, trachea, carina, and large intrapulmonary bronchi. Other bronchopulmonary sensory nerves, sensory nerves innervating other viscera, as well as somatosensory nerves innervating the chest wall, diaphragm, and abdominal musculature regulate cough patterning and cough sensitivity. The responsiveness and morphology of the airway vagal sensory nerve subtypes and the extrapulmonary sensory nerves that regulate coughing are described. The brainstem and higher brain control systems that process this sensory information are complex, but our current understanding of them is considerable and increasing. The relevance of these neural systems to clinical phenomena, such as urge to cough and psychologic methods for treatment of dystussia, is high, and modern imaging methods have revealed potential neural substrates for some features of cough in the human.
| Original language | English |
|---|---|
| Pages (from-to) | 1633-1648 |
| Number of pages | 16 |
| Journal | Chest |
| Volume | 146 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Dec 2014 |
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Anatomy and Neurophysiology of Cough : CHEST Guideline and Expert Panel Report. / Canning, Brendan J.; Chang, Anne B.; Bolser, Donald C.; Smith, Jaclyn A.; Mazzone, Stuart B.; McGarvey, Lorcan; CHEST Expert Cough Panel.
In: Chest, Vol. 146, No. 6, 01.12.2014, p. 1633-1648.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Anatomy and Neurophysiology of Cough
T2 - CHEST Guideline and Expert Panel Report
AU - Canning, Brendan J.
AU - Chang, Anne B.
AU - Bolser, Donald C.
AU - Smith, Jaclyn A.
AU - Mazzone, Stuart B.
AU - McGarvey, Lorcan
AU - CHEST Expert Cough Panel
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminate primarily in the larynx, trachea, carina, and large intrapulmonary bronchi. Other bronchopulmonary sensory nerves, sensory nerves innervating other viscera, as well as somatosensory nerves innervating the chest wall, diaphragm, and abdominal musculature regulate cough patterning and cough sensitivity. The responsiveness and morphology of the airway vagal sensory nerve subtypes and the extrapulmonary sensory nerves that regulate coughing are described. The brainstem and higher brain control systems that process this sensory information are complex, but our current understanding of them is considerable and increasing. The relevance of these neural systems to clinical phenomena, such as urge to cough and psychologic methods for treatment of dystussia, is high, and modern imaging methods have revealed potential neural substrates for some features of cough in the human.
AB - Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminate primarily in the larynx, trachea, carina, and large intrapulmonary bronchi. Other bronchopulmonary sensory nerves, sensory nerves innervating other viscera, as well as somatosensory nerves innervating the chest wall, diaphragm, and abdominal musculature regulate cough patterning and cough sensitivity. The responsiveness and morphology of the airway vagal sensory nerve subtypes and the extrapulmonary sensory nerves that regulate coughing are described. The brainstem and higher brain control systems that process this sensory information are complex, but our current understanding of them is considerable and increasing. The relevance of these neural systems to clinical phenomena, such as urge to cough and psychologic methods for treatment of dystussia, is high, and modern imaging methods have revealed potential neural substrates for some features of cough in the human.
UR - http://www.scopus.com/inward/record.url?scp=84964698097&partnerID=8YFLogxK
U2 - 10.1378/chest.14-1481
DO - 10.1378/chest.14-1481
M3 - Article
VL - 146
SP - 1633
EP - 1648
JO - Chest
JF - Chest
SN - 0012-3692
IS - 6
ER -