Anti-RNA polymerase III antibodies in the diagnosis of scleroderma renal crisis sine scleroderma

Tri Giang Phan, Alan Cass, Adrian Gillin, Phillip Trew, Noreen Fertig, Allan Sturgess

Research output: Contribution to journalArticle

Abstract

We describe the use of antibodies to RNA polymerase III in the diagnosis of scleroderma in 2 patients who presented with renal crisis without other clinical features of the condition. Both presented with accelerated hypertension, rapidly progressive acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia. One patient developed digital infarcts in the course of his initial illness. Neither showed evidence of skin thickening at presentation. Nailfold capillaroscopy was normal in one patient and showed capillary dropout in the other. Renal biopsy showed findings consistent with thrombotic microangiopathy and both had anti-RNA polymerase III antibodies.

Original languageEnglish
Pages (from-to)2489-2492
Number of pages4
JournalJournal of Rheumatology
Volume26
Issue number11
Publication statusPublished - 1 Nov 1999
Externally publishedYes

Fingerprint Dive into the research topics of 'Anti-RNA polymerase III antibodies in the diagnosis of scleroderma renal crisis sine scleroderma'. Together they form a unique fingerprint.

  • Cite this

    Phan, T. G., Cass, A., Gillin, A., Trew, P., Fertig, N., & Sturgess, A. (1999). Anti-RNA polymerase III antibodies in the diagnosis of scleroderma renal crisis sine scleroderma. Journal of Rheumatology, 26(11), 2489-2492.