Antibodies to serotype 9V exhibit novel serogroup cross-reactivity following infant pneumococcal immunization

Paul Licciardi, Anne Balloch, Fiona Russell, Edward (Kim) MULHOLLAND, Mimi Tang

    Research output: Contribution to journalArticle

    Abstract

    Cross-reactivity within the pneumococcal immune response was examined in this study. Significant cross-reactivity between serotypes 9V, 15B and 19A was identified in infant post-immunization serum that could not be effectively titrated during specific IgG measurements. Pre-absorption using serotype 9V inhibited this cross-reactivity and normalized titratability in the WHO ELISA for serotypes 15B and 19A. However, this did not affect functional avid IgG and was associated with fewer pneumococcal conjugate vaccine (PCV) doses, suggesting that cross-reactive antibodies were of low avidity. The results in this study have important implications for assessment of vaccine immunogenicity.
    Original languageEnglish
    Pages (from-to)3793-3800
    Number of pages8
    JournalVaccine
    Volume28
    Issue number22
    DOIs
    Publication statusPublished - 14 May 2010

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