Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from Papua New Guinea

K Trenholme, C BOUTLIS, R Kuns, M Lagog, M Bockarie, M Gatton, D KEMP, M GOOD, Nicholas Anstey, D Gardiner

    Research output: Contribution to journalArticle

    Abstract

    The cytoadherence-linked asexual gene 9 (clag 9) of Plasmodium falciparum has been implicated in the cytoadherence of infected erythrocytes. To determine the immunogenicity of the clag 9 gene product (CLAG 9 protein) in humans, we measured antibody responses to 11 synthetic CLAG 9 peptides in a group of 177 asymptomatic children and adults subject to intense malaria exposure in Madang, Papua New Guinea. The CLAG 9 peptides were immunogenic in adults and children. Antibody responses to peptides 4 and 10 were high across all age groups and detectable in a majority of children less than five years of age. While CLAG 9 peptides are immunogenic in humans, longitudinal studies will be required to determine the longevity of antibody responses to CLAG 9 and their role in protection from disease. Copyright � 2005 by The American Society of Tropical Medicine and Hygiene.
    Original languageEnglish
    Pages (from-to)708-713
    Number of pages6
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume72
    Issue number6
    Publication statusPublished - 2005

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