@article{7d37b6a28bce454a8b1596a72656fc05,
title = "Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from Papua New Guinea",
abstract = "The cytoadherence-linked asexual gene 9 (clag 9) of Plasmodium falciparum has been implicated in the cytoadherence of infected erythrocytes. To determine the immunogenicity of the clag 9 gene product (CLAG 9 protein) in humans, we measured antibody responses to 11 synthetic CLAG 9 peptides in a group of 177 asymptomatic children and adults subject to intense malaria exposure in Madang, Papua New Guinea. The CLAG 9 peptides were immunogenic in adults and children. Antibody responses to peptides 4 and 10 were high across all age groups and detectable in a majority of children less than five years of age. While CLAG 9 peptides are immunogenic in humans, longitudinal studies will be required to determine the longevity of antibody responses to CLAG 9 and their role in protection from disease. Copyright � 2005 by The American Society of Tropical Medicine and Hygiene.",
keywords = "epitope, gene product, parasite antigen, peptide derivative, protozoon antibody, cell adhesion molecule, clag9 protein, Plasmodium falciparum, protozoal protein, adolescent, adult, antibody response, antigen antibody reaction, article, asexual reproduction, cell adhesion, cell protection, child, clag9 gene, endothelium cell, female, gene, human, immunogenicity, longevity, longitudinal study, major clinical study, malaria falciparum, male, Papua New Guinea, Plasmodium falciparum, symptomatology, amino acid sequence, animal, chemistry, genetics, immunology, molecular genetics, sequence homology, Adult, Amino Acid Sequence, Animals, Antibodies, Protozoan, Cell Adhesion, Cell Adhesion Molecules, Child, Genes, Protozoan, Humans, Molecular Sequence Data, New Guinea, Protozoan Proteins, Sequence Homology, Amino Acid",
author = "K Trenholme and C BOUTLIS and R Kuns and M Lagog and M Bockarie and M Gatton and D KEMP and M GOOD and Nicholas Anstey and D Gardiner",
year = "2005",
language = "English",
volume = "72",
pages = "708--713",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "6",
}
