Background: Non-specific cough is defined as non-productive cough in the absence of identifiable respiratory disease or known aetiology. It is commonly seen in paediatric practice. These children are treated with a variety of therapies including inhaled anti-cholinergic medications. Objectives: To determine the efficacy of inhaled anti-cholinergic medications in the management of prolonged non-specific cough in children. Search methods: The Cochrane Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE databases were searched. Relevant pharmaceutical companies were contacted. The latest searches were carried out in April 2010. Selection criteria: All randomised controlled trials comparing inhaled anti-cholinergic medication with a placebo medication. Data collection and analysis: Results of searches were reviewed against pre-determined criteria for inclusion. No eligible trials were identified and thus no data were available for analysis. A single small trial in adults has been reported. Main results: No randomised-controlled trials that examined the efficacy of inhaled anti-cholinergic medications in the management of prolonged non-specific cough in children were found. An additional search in April 2010 did not identify any further studies. Authors' conclusions: There is currently no evidence to support the use of inhaled anti-cholinergics for symptomatic control of non-specific cough in children. Further research examining the effects of this intervention is needed.