@article{df4a3431f9184469b5c6959ae397020d,
title = "Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine",
abstract = "RTS,S/AS01, a vaccine targeting pre-erythrocytic stages of Plasmodium falciparum, isundergoing clinical trials. We report an analysis of cellular immune responseto component Ags of RTS,S—hepatitis B surface Ag (HBs) and P. falciparum circumsporozoite(CS) protein—among Tanzanian children in a phase IIb RTS,S/AS01E trial. RTS,S/AS01 E vaccineesmake stronger T cell IFN-γ, CD69, and CD25 responses to HBs peptides than docontrols, indicating that RTS,S boosts pre-existing HBs responses. T cell CD69and CD25 responses to CS and CS-specific secreted IL-2 were augmented by RTS,Svaccination. Importantly, more than 50% of peptide-induced IFN-γ+ lymphocytes were NK cells, and the magnitude of the NK cellCD69 response to HBs peptides correlated with secreted IL-2 concentration. CD69and CD25 expression and IL-2 secretion may represent sensitive markers ofRTS,S-induced, CS-specific T cells. The potential for T cell-derived IL-2 toaugment NK cell activation in RTS,S-vaccinated individuals, and the relevanceof this for protection, needs to be explored further.",
keywords = "CD69 antigen, gamma interferon, hepatitis B surface antigen, immunological adjuvant, interleukin 2, interleukin 2 receptor alpha, malaria vaccine, rts s, unclassified drug, virus protein, antigen expression, article, cell activation, cell activity, cellular immunity, child, cohort analysis, concentration response, controlled study, cytokine release, double blind procedure, drug targeting, female, human, human cell, immunization, infant, lymphocyte, malaria, male, natural killer cell, phase 2 clinical trial, priority journal, randomized controlled trial, T lymphocyte, Tanzania, Biological Markers, Cells, Cultured, Epitopes, Humans, Infant, Interleukin-2, Kenya, Killer Cells, Natural, Lymphocyte Activation, Malaria Vaccines, Plasmodium falciparum, Protozoan Proteins, T-Lymphocyte Subsets",
author = "Amir Horowitz and Julius Hafalla and Elizabeth King and John Lusingu and Denise Dekker and Amanda Leach and Philippe Moris and Joe Cohen and Johan Vekemans and Tonya Villafana and Patrick Corran and Chris Drakeley and {Von Seidlein}, Lorenz and Riley, {Eleanor M}",
year = "2012",
month = may,
day = "15",
doi = "10.4049/jimmunol.1102710",
language = "English",
volume = "188",
pages = "5054--5062",
journal = "Journal of Immunology",
issn = "1550-6606",
publisher = "American Association of Immunologists",
number = "10",
}