Antimalarial activity of tigecycline, a novel glycylcycline antibiotic

Peter Starzengrüber, Kamala Ley-Thriemer, Rashidul Haque, Wasifali Khan, Hans Fuehrer, Anja Siedl, Verena Hofecker, Benedikt Ley, Walther Wernsdorfer, Harald Noedl

Research output: Contribution to journalArticlepeer-review

Abstract

Tigecycline is a novel glycylcycline antibiotic with a broad antibacterial spectrum. Tigecycline was tested with 66 clinical isolates of Plasmodium falciparum from Bangladesh using the histidine-rich protein 2 in vitro drug susceptibility assay. The 50% and 90% inhibitory concentrations of tigecycline were 699 (95% confidence
interval, 496 to 986) and 5,905 nM (4,344 to 8,028). Tigecycline shows no activity correlation with traditional antimalarials and has substantial antimalarial activity on its own.
Original languageEnglish
Pages (from-to)4040-4042
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number9
DOIs
Publication statusPublished - 2009

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