Antimalarial activity of tigecycline, a novel glycylcycline antibiotic

Peter Starzengrüber, Kamala Ley-Thriemer, Rashidul Haque, Wasifali Khan, Hans Fuehrer, Anja Siedl, Verena Hofecker, Benedikt Ley, Walther Wernsdorfer, Harald Noedl

    Research output: Contribution to journalArticle

    Abstract

    Tigecycline is a novel glycylcycline antibiotic with a broad antibacterial spectrum. Tigecycline was tested with 66 clinical isolates of Plasmodium falciparum from Bangladesh using the histidine-rich protein 2 in vitro drug susceptibility assay. The 50% and 90% inhibitory concentrations of tigecycline were 699 (95% confidence
    interval, 496 to 986) and 5,905 nM (4,344 to 8,028). Tigecycline shows no activity correlation with traditional antimalarials and has substantial antimalarial activity on its own.
    Original languageEnglish
    Pages (from-to)4040-4042
    Number of pages3
    JournalAntimicrobial Agents and Chemotherapy
    Volume53
    Issue number9
    DOIs
    Publication statusPublished - 2009

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