Antimalarial activity of tigecycline, a novel glycylcycline antibiotic

Peter StarzengrÃ¼ber; Kamala Ley-Thriemer; Rashidul Haque; Wasifali Khan; Hans Fuehrer; Anja Siedl; Verena Hofecker; Benedikt Ley; Walther Wernsdorfer; Harald Noedl

doi:10.1128/AAC.00312-09

Antimalarial activity of tigecycline, a novel glycylcycline antibiotic

Peter StarzengrÃ¼ber, Kamala Ley-Thriemer, Rashidul Haque, Wasifali Khan, Hans Fuehrer, Anja Siedl, Verena Hofecker, Benedikt Ley, Walther Wernsdorfer, Harald Noedl

Research output: Contribution to journal › Article › peer-review

Abstract

Tigecycline is a novel glycylcycline antibiotic with a broad antibacterial spectrum. Tigecycline was tested with 66 clinical isolates of Plasmodium falciparum from Bangladesh using the histidine-rich protein 2 in vitro drug susceptibility assay. The 50% and 90% inhibitory concentrations of tigecycline were 699 (95% confidence
interval, 496 to 986) and 5,905 nM (4,344 to 8,028). Tigecycline shows no activity correlation with traditional antimalarials and has substantial antimalarial activity on its own.

Original language	English
Pages (from-to)	4040-4042
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	53
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00312-09
Publication status	Published - 2009

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abstract = "Tigecycline is a novel glycylcycline antibiotic with a broad antibacterial spectrum. Tigecycline was tested with 66 clinical isolates of Plasmodium falciparum from Bangladesh using the histidine-rich protein 2 in vitro drug susceptibility assay. The 50% and 90% inhibitory concentrations of tigecycline were 699 (95% confidenceinterval, 496 to 986) and 5,905 nM (4,344 to 8,028). Tigecycline shows no activity correlation with traditional antimalarials and has substantial antimalarial activity on its own.",

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AU - StarzengrÃ¼ber, Peter

AU - Ley-Thriemer, Kamala

AU - Haque, Rashidul

AU - Khan, Wasifali

AU - Fuehrer, Hans

AU - Siedl, Anja

AU - Hofecker, Verena

AU - Ley, Benedikt

AU - Wernsdorfer, Walther

AU - Noedl, Harald

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AB - Tigecycline is a novel glycylcycline antibiotic with a broad antibacterial spectrum. Tigecycline was tested with 66 clinical isolates of Plasmodium falciparum from Bangladesh using the histidine-rich protein 2 in vitro drug susceptibility assay. The 50% and 90% inhibitory concentrations of tigecycline were 699 (95% confidenceinterval, 496 to 986) and 5,905 nM (4,344 to 8,028). Tigecycline shows no activity correlation with traditional antimalarials and has substantial antimalarial activity on its own.

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JF - Antimicrobial Agents and Chemotherapy

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ER -

Antimalarial activity of tigecycline, a novel glycylcycline antibiotic

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