Aqueous Suzuki-Miyaura coupling with ultralow palladium loading and simple product separation

Wei Yang, Wen Di Xu, Jin Jiao Ning, Zhi Gang Ren, David James Young

Research output: Contribution to journalArticle

Abstract

The diphosphine ligand N, N -bis(diphenylphosphanylmethyl)-aniline (bdppma) and PdCl 2afforded a Suzuki-Miyaura catalyst [(bdppm-)PdCl 2] that was highly efficient at an ultralow catalyst loading (0.001 mol%) in 20:1 H 2O-EtOH. This low catalyst loading in an aqueous solvent system permitted simple product separation by direct filtration without the need for chromatography. The ligand bdppma imparted surprisingly better reactivity than that achieved with other bidentate diphosphine ligands, but the catalytic system had a slightly narrower substrate scope than some similar Pd catalysts reported previously.

Original languageEnglish
Pages (from-to)1303-1307
Number of pages5
JournalSynlett
Volume31
Issue number13
DOIs
Publication statusPublished - 12 Aug 2020

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