Area-based differentials in childhood cancer incidence in Australia, 1996-2006

Danny Youlden, Peter Baade, Patricia Valery, Timothy Hassall, Leisa Ward, Adele Green, Joanne Aitken

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Abstract

Background: International studies examining theassociation between the incidence of childhood cancer and characteristics ofthe area in which the patient lives have generally reported inconsistentpatterns. Area-based differentials in childhood cancer throughout Australiahave not been previously published at a national level.

Procedure: Population-based information from theAustralian Paediatric Cancer Registry was used to identify all children aged 0-to 14-years old diagnosed with invasive cancer or intracranial and intraspinaltumors of benign or uncertain behavior between 1996 and 2006. Age-standardizedincidence rates per million children per year and the corresponding incidencerate ratios were calculated, categorized by remoteness of residence and anarea-based index of socioeconomic disadvantage. Results were also stratified bythe most common types of childhood cancer.

Results: There was a significant, decreasing gradient in the incidence ofchildhood cancer as remoteness of residence increased. Children living inremote or very remote areas were 21% less likely to be diagnosed with cancercompared to children in major cities, mainly due to differences in theincidence of leukemias and lymphomas. This differential was no longersignificant when only non-Indigenous children were considered. No clearrelationship was found between incidence and socioeconomic status (SES) incontrast to similar earlier studies.

Conclusions: The findings by remoteness of residence areconsistent with the lower incidence rates of cancer that are typicallyassociated with Indigenous Australians. There is also a suggestion that theetiological factors associated with childhood leukemia and SES may have alteredover time. 

Original languageEnglish
Pages (from-to)390-394
Number of pages5
JournalPediatric Blood and Cancer
Volume58
Issue number3
DOIs
Publication statusPublished - Mar 2012
Externally publishedYes

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Incidence
Neoplasms
Social Class
Leukemia
Registries
Lymphoma
Pediatrics
Population

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Youlden, D., Baade, P., Valery, P., Hassall, T., Ward, L., Green, A., & Aitken, J. (2012). Area-based differentials in childhood cancer incidence in Australia, 1996-2006. Pediatric Blood and Cancer, 58(3), 390-394. https://doi.org/10.1002/pbc.23115
Youlden, Danny ; Baade, Peter ; Valery, Patricia ; Hassall, Timothy ; Ward, Leisa ; Green, Adele ; Aitken, Joanne. / Area-based differentials in childhood cancer incidence in Australia, 1996-2006. In: Pediatric Blood and Cancer. 2012 ; Vol. 58, No. 3. pp. 390-394.
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Youlden, D, Baade, P, Valery, P, Hassall, T, Ward, L, Green, A & Aitken, J 2012, 'Area-based differentials in childhood cancer incidence in Australia, 1996-2006', Pediatric Blood and Cancer, vol. 58, no. 3, pp. 390-394. https://doi.org/10.1002/pbc.23115

Area-based differentials in childhood cancer incidence in Australia, 1996-2006. / Youlden, Danny; Baade, Peter; Valery, Patricia ; Hassall, Timothy; Ward, Leisa; Green, Adele; Aitken, Joanne.

In: Pediatric Blood and Cancer, Vol. 58, No. 3, 03.2012, p. 390-394.

Research output: Contribution to journalArticleResearchpeer-review

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JF - Pediatric Blood and Cancer

SN - 0098-1532

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Youlden D, Baade P, Valery P, Hassall T, Ward L, Green A et al. Area-based differentials in childhood cancer incidence in Australia, 1996-2006. Pediatric Blood and Cancer. 2012 Mar;58(3):390-394. https://doi.org/10.1002/pbc.23115