Robert Commons, Julia Simpson, Ric Price

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Lumefantrine (formerly benflumetol) is an arylaminoalcohol anti-malarial drug first synthesized at the Academy of Military Medical Science, Beijing, China, but with the earliest description of benflumetol in the English literature in 1990 (World Health Organization [WHO], 1990). The chemical structure (α–[dibutylaminomethyl]-2,7-dichloro-9[p-chlorobenzylidene]-4-fluorenemethanol) results in a molecular structure similar to that of the Cinchona alkaloids, the synthetic production process producing a 1:1 racemic mixture of dextrogyral and levogyral stereo-enantiomers. It is highly lipophilic and weakly basic and readily dissolves in nonpolar or aprotic organic solvents (Kotila et al., 2013).
Original languageEnglish
Title of host publicationKucers' The Use of Antibiotics
Subtitle of host publicationA clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs
EditorsM. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson
Place of PublicationBoca Raton
PublisherCRC Press
Number of pages15
ISBN (Electronic)9781315152110
Publication statusPublished - 2 Oct 2017

Bibliographical note

Three volumes set


Dive into the research topics of 'Artemether-Lumefantrine'. Together they form a unique fingerprint.

Cite this