Artemether-Lumefantrine

Robert Commons, Julia Simpson, Ric Price

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    Abstract

    Lumefantrine (formerly benflumetol) is an arylaminoalcohol anti-malarial drug first synthesized at the Academy of Military Medical Science, Beijing, China, but with the earliest description of benflumetol in the English literature in 1990 (World Health Organization [WHO], 1990). The chemical structure (α–[dibutylaminomethyl]-2,7-dichloro-9[p-chlorobenzylidene]-4-fluorenemethanol) results in a molecular structure similar to that of the Cinchona alkaloids, the synthetic production process producing a 1:1 racemic mixture of dextrogyral and levogyral stereo-enantiomers. It is highly lipophilic and weakly basic and readily dissolves in nonpolar or aprotic organic solvents (Kotila et al., 2013).
    Original languageEnglish
    Title of host publicationKucers' The Use of Antibiotics
    Subtitle of host publicationA clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs
    EditorsM. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson
    Place of PublicationBoca Raton
    PublisherCRC Press
    Chapter171
    Pages2974-2988
    Number of pages15
    Volume3
    Edition7th
    ISBN (Electronic)9781315152110
    DOIs
    Publication statusPublished - 2 Oct 2017

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