Artemether-Lumefantrine

Robert Commons; Julia Simpson; Ric Price

doi:10.1201/9781498747967

Artemether-Lumefantrine

Robert Commons, Julia Simpson, Ric Price

Global and Tropical Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Lumefantrine (formerly benflumetol) is an arylaminoalcohol anti-malarial drug first synthesized at the Academy of Military Medical Science, Beijing, China, but with the earliest description of benflumetol in the English literature in 1990 (World Health Organization [WHO], 1990). The chemical structure (α–[dibutylaminomethyl]-2,7-dichloro-9[p-chlorobenzylidene]-4-fluorenemethanol) results in a molecular structure similar to that of the Cinchona alkaloids, the synthetic production process producing a 1:1 racemic mixture of dextrogyral and levogyral stereo-enantiomers. It is highly lipophilic and weakly basic and readily dissolves in nonpolar or aprotic organic solvents (Kotila et al., 2013).

Original language	English
Title of host publication	Kucers' The Use of Antibiotics
Subtitle of host publication	A clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs
Editors	M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson
Place of Publication	Boca Raton
Publisher	CRC Press
Chapter	171
Pages	2974-2988
Number of pages	15
Volume	3
Edition	7th
ISBN (Electronic)	9781315152110
DOIs	https://doi.org/10.1201/9781498747967
Publication status	Published - 2 Oct 2017

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10.1201/9781498747967

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Commons, R., Simpson, J., & Price, R. (2017). Artemether-Lumefantrine. In M. L. Grayson, S. E. Cosgrove, S. M. Crowe, W. Hope, J. S. McCarthy, J. Mills, J. W. Mouton, & D. L. Paterson (Eds.), Kucers' The Use of Antibiotics: A clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs (7th ed., Vol. 3, pp. 2974-2988). CRC Press. https://doi.org/10.1201/9781498747967

Commons, Robert ; Simpson, Julia ; Price, Ric. / Artemether-Lumefantrine. Kucers' The Use of Antibiotics: A clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs. editor / M. Lindsay Grayson ; Sara E. Cosgrove ; Suzanne M. Crowe ; William Hope ; James S. McCarthy ; John Mills ; Johan W. Mouton ; David L. Paterson. Vol. 3 7th. ed. Boca Raton : CRC Press, 2017. pp. 2974-2988

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abstract = "Lumefantrine (formerly benflumetol) is an arylaminoalcohol anti-malarial drug first synthesized at the Academy of Military Medical Science, Beijing, China, but with the earliest description of benflumetol in the English literature in 1990 (World Health Organization [WHO], 1990). The chemical structure (α–[dibutylaminomethyl]-2,7-dichloro-9[p-chlorobenzylidene]-4-fluorenemethanol) results in a molecular structure similar to that of the Cinchona alkaloids, the synthetic production process producing a 1:1 racemic mixture of dextrogyral and levogyral stereo-enantiomers. It is highly lipophilic and weakly basic and readily dissolves in nonpolar or aprotic organic solvents (Kotila et al., 2013).",

author = "Robert Commons and Julia Simpson and Ric Price",

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Commons, R, Simpson, J & Price, R 2017, Artemether-Lumefantrine. in ML Grayson, SE Cosgrove, SM Crowe, W Hope, JS McCarthy, J Mills, JW Mouton & DL Paterson (eds), Kucers' The Use of Antibiotics: A clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs. 7th edn, vol. 3, CRC Press, Boca Raton, pp. 2974-2988. https://doi.org/10.1201/9781498747967

Artemether-Lumefantrine. / Commons, Robert; Simpson, Julia; Price, Ric.
Kucers' The Use of Antibiotics: A clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs. ed. / M. Lindsay Grayson; Sara E. Cosgrove; Suzanne M. Crowe; William Hope; James S. McCarthy; John Mills; Johan W. Mouton; David L. Paterson. Vol. 3 7th. ed. Boca Raton: CRC Press, 2017. p. 2974-2988.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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N2 - Lumefantrine (formerly benflumetol) is an arylaminoalcohol anti-malarial drug first synthesized at the Academy of Military Medical Science, Beijing, China, but with the earliest description of benflumetol in the English literature in 1990 (World Health Organization [WHO], 1990). The chemical structure (α–[dibutylaminomethyl]-2,7-dichloro-9[p-chlorobenzylidene]-4-fluorenemethanol) results in a molecular structure similar to that of the Cinchona alkaloids, the synthetic production process producing a 1:1 racemic mixture of dextrogyral and levogyral stereo-enantiomers. It is highly lipophilic and weakly basic and readily dissolves in nonpolar or aprotic organic solvents (Kotila et al., 2013).

AB - Lumefantrine (formerly benflumetol) is an arylaminoalcohol anti-malarial drug first synthesized at the Academy of Military Medical Science, Beijing, China, but with the earliest description of benflumetol in the English literature in 1990 (World Health Organization [WHO], 1990). The chemical structure (α–[dibutylaminomethyl]-2,7-dichloro-9[p-chlorobenzylidene]-4-fluorenemethanol) results in a molecular structure similar to that of the Cinchona alkaloids, the synthetic production process producing a 1:1 racemic mixture of dextrogyral and levogyral stereo-enantiomers. It is highly lipophilic and weakly basic and readily dissolves in nonpolar or aprotic organic solvents (Kotila et al., 2013).

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DO - 10.1201/9781498747967

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BT - Kucers' The Use of Antibiotics

A2 - Grayson, M. Lindsay

A2 - Cosgrove, Sara E.

A2 - Crowe, Suzanne M.

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A2 - Mills, John

A2 - Mouton, Johan W.

A2 - Paterson, David L.

PB - CRC Press

CY - Boca Raton

ER -

Artemether-Lumefantrine

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