Lumefantrine (formerly benflumetol) is an arylaminoalcohol anti-malarial drug first synthesized at the Academy of Military Medical Science, Beijing, China, but with the earliest description of benflumetol in the English literature in 1990 (World Health Organization [WHO], 1990). The chemical structure (α–[dibutylaminomethyl]-2,7-dichloro-9[p-chlorobenzylidene]-4-fluorenemethanol) results in a molecular structure similar to that of the Cinchona alkaloids, the synthetic production process producing a 1:1 racemic mixture of dextrogyral and levogyral stereo-enantiomers. It is highly lipophilic and weakly basic and readily dissolves in nonpolar or aprotic organic solvents (Kotila et al., 2013).
|Title of host publication||Kucers' The Use of Antibiotics|
|Subtitle of host publication||A clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs|
|Editors||M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson|
|Place of Publication||Boca Raton|
|Number of pages||15|
|Publication status||Published - 2 Oct 2017|