Artemisinin resistance: current status and scenarios for containment

Arjen Dondorp, Shunmay Yeung, Lisa White, Chea Nguon, Nicholas Day, Duong Socheat, Lorenz Von Seidlein

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Artemisinin combination therapies are the first-line treatments for uncomplicated Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial artemisinin-resistant P. falciparum malaria has emerged on the Cambodiaĝ€"Thailand border. Exposure of the parasite population to artemisinin monotherapies in subtherapeutic doses for over 30 years, and the availability of substandard artemisinins, have probably been the main driving force in the selection of the resistant phenotype in the region. A multifaceted containment programme has recently been launched, including early diagnosis and appropriate treatment, decreasing drug pressure, optimising vector control, targeting the mobile population, strengthening management and surveillance systems, and operational research. Mathematical modelling can be a useful tool to evaluate possible strategies for containment.
    Original languageEnglish
    Pages (from-to)272-280
    Number of pages9
    JournalNature Reviews Microbiology
    Volume8
    Issue number4
    Early online date8 Mar 2010
    DOIs
    Publication statusPublished - Apr 2010

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