Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

Nicholas J. White, Elizabeth A. Ashley, Judith Recht, Michael J. Delves, Andrea Ruecker, Frank M. Smithuis, Alice C. Eziefula, Teun Bousema, Chris Drakeley, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Jetsumon Prachumsri, Cindy Chu, Chiara Andolina, Germana Bancone, Tran T. Hien, Mayfong Mayxay, Walter R.J. Taylor, Lorenz Von Seidlein & 13 others Ric N. Price, Karen I. Barnes, Abdoulaye Djimdé, Feiko Ter Kuile, Roly Gosling, Ingrid Chen, Mehul J. Dhorda, Kasia Stepniewska, Philippe Guérin, Charles J. Woodrow, Arjen M. Dondorp, Nicholas P.J. Day, Francois H. Nosten

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.

Original languageEnglish
Article number483
Pages (from-to)1-13
Number of pages13
JournalMalaria Journal
Volume13
Issue number1
DOIs
Publication statusPublished - 2014

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Falciparum Malaria
Area Under Curve
Pharmaceutical Preparations
Antimalarials
Plasmodium falciparum
Culicidae
Therapeutics

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White, N. J., Ashley, E. A., Recht, J., Delves, M. J., Ruecker, A., Smithuis, F. M., ... Nosten, F. H. (2014). Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malaria Journal, 13(1), 1-13. [483]. https://doi.org/10.1186/1475-2875-13-483
White, Nicholas J. ; Ashley, Elizabeth A. ; Recht, Judith ; Delves, Michael J. ; Ruecker, Andrea ; Smithuis, Frank M. ; Eziefula, Alice C. ; Bousema, Teun ; Drakeley, Chris ; Chotivanich, Kesinee ; Imwong, Mallika ; Pukrittayakamee, Sasithon ; Prachumsri, Jetsumon ; Chu, Cindy ; Andolina, Chiara ; Bancone, Germana ; Hien, Tran T. ; Mayxay, Mayfong ; Taylor, Walter R.J. ; Von Seidlein, Lorenz ; Price, Ric N. ; Barnes, Karen I. ; Djimdé, Abdoulaye ; Kuile, Feiko Ter ; Gosling, Roly ; Chen, Ingrid ; Dhorda, Mehul J. ; Stepniewska, Kasia ; Guérin, Philippe ; Woodrow, Charles J. ; Dondorp, Arjen M. ; Day, Nicholas P.J. ; Nosten, Francois H. / Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. In: Malaria Journal. 2014 ; Vol. 13, No. 1. pp. 1-13.
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abstract = "Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.",
author = "White, {Nicholas J.} and Ashley, {Elizabeth A.} and Judith Recht and Delves, {Michael J.} and Andrea Ruecker and Smithuis, {Frank M.} and Eziefula, {Alice C.} and Teun Bousema and Chris Drakeley and Kesinee Chotivanich and Mallika Imwong and Sasithon Pukrittayakamee and Jetsumon Prachumsri and Cindy Chu and Chiara Andolina and Germana Bancone and Hien, {Tran T.} and Mayfong Mayxay and Taylor, {Walter R.J.} and {Von Seidlein}, Lorenz and Price, {Ric N.} and Barnes, {Karen I.} and Abdoulaye Djimd{\~A}{\circledC} and Kuile, {Feiko Ter} and Roly Gosling and Ingrid Chen and Dhorda, {Mehul J.} and Kasia Stepniewska and Philippe Gu{\~A}{\circledC}rin and Woodrow, {Charles J.} and Dondorp, {Arjen M.} and Day, {Nicholas P.J.} and Nosten, {Francois H.}",
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White, NJ, Ashley, EA, Recht, J, Delves, MJ, Ruecker, A, Smithuis, FM, Eziefula, AC, Bousema, T, Drakeley, C, Chotivanich, K, Imwong, M, Pukrittayakamee, S, Prachumsri, J, Chu, C, Andolina, C, Bancone, G, Hien, TT, Mayxay, M, Taylor, WRJ, Von Seidlein, L, Price, RN, Barnes, KI, Djimdé, A, Kuile, FT, Gosling, R, Chen, I, Dhorda, MJ, Stepniewska, K, Guérin, P, Woodrow, CJ, Dondorp, AM, Day, NPJ & Nosten, FH 2014, 'Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria', Malaria Journal, vol. 13, no. 1, 483, pp. 1-13. https://doi.org/10.1186/1475-2875-13-483

Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. / White, Nicholas J.; Ashley, Elizabeth A.; Recht, Judith; Delves, Michael J.; Ruecker, Andrea; Smithuis, Frank M.; Eziefula, Alice C.; Bousema, Teun; Drakeley, Chris; Chotivanich, Kesinee; Imwong, Mallika; Pukrittayakamee, Sasithon; Prachumsri, Jetsumon; Chu, Cindy; Andolina, Chiara; Bancone, Germana; Hien, Tran T.; Mayxay, Mayfong; Taylor, Walter R.J.; Von Seidlein, Lorenz; Price, Ric N.; Barnes, Karen I.; Djimdé, Abdoulaye; Kuile, Feiko Ter; Gosling, Roly; Chen, Ingrid; Dhorda, Mehul J.; Stepniewska, Kasia; Guérin, Philippe; Woodrow, Charles J.; Dondorp, Arjen M.; Day, Nicholas P.J.; Nosten, Francois H.

In: Malaria Journal, Vol. 13, No. 1, 483, 2014, p. 1-13.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

AU - White, Nicholas J.

AU - Ashley, Elizabeth A.

AU - Recht, Judith

AU - Delves, Michael J.

AU - Ruecker, Andrea

AU - Smithuis, Frank M.

AU - Eziefula, Alice C.

AU - Bousema, Teun

AU - Drakeley, Chris

AU - Chotivanich, Kesinee

AU - Imwong, Mallika

AU - Pukrittayakamee, Sasithon

AU - Prachumsri, Jetsumon

AU - Chu, Cindy

AU - Andolina, Chiara

AU - Bancone, Germana

AU - Hien, Tran T.

AU - Mayxay, Mayfong

AU - Taylor, Walter R.J.

AU - Von Seidlein, Lorenz

AU - Price, Ric N.

AU - Barnes, Karen I.

AU - Djimdé, Abdoulaye

AU - Kuile, Feiko Ter

AU - Gosling, Roly

AU - Chen, Ingrid

AU - Dhorda, Mehul J.

AU - Stepniewska, Kasia

AU - Guérin, Philippe

AU - Woodrow, Charles J.

AU - Dondorp, Arjen M.

AU - Day, Nicholas P.J.

AU - Nosten, Francois H.

PY - 2014

Y1 - 2014

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AB - Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.

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U2 - 10.1186/1475-2875-13-483

DO - 10.1186/1475-2875-13-483

M3 - Review article

VL - 13

SP - 1

EP - 13

JO - Malaria Journal

JF - Malaria Journal

SN - 1475-2875

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ER -