Association between perinatal and early life exposures and lung function in Australian Indigenous young adults: The Aboriginal Birth Cohort study

Vidya Navaratnam; Douglas L. Forrester; Anne B. Chang; Shyamali C. Dharmage; Gurmeet R. Singh

doi:10.1111/resp.14639

Association between perinatal and early life exposures and lung function in Australian Indigenous young adults: The Aboriginal Birth Cohort study

Vidya Navaratnam, Douglas L. Forrester, Anne B. Chang, Shyamali C. Dharmage, Gurmeet R. Singh

Child and Maternal Health

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

44 Downloads (Pure)

Abstract

Background and Objective: Despite the high burden of respiratory disease amongst Indigenous populations, prevalence data on spirometric deficits and its determinants are limited. We estimated the prevalence of abnormal spirometry in young Indigenous adults and determined its relationship with perinatal and early life factors. Methods: We used prospectively collected data from the Australian Aboriginal Birth Cohort, a birth cohort of 686 Indigenous Australian singletons. We calculated the proportion with abnormal spirometry (z-score <−1.64) and FEV₁ below the population mean (FEV₁% predicted 0 to −2SD) measured in young adulthood. We evaluated the association between perinatal and early life exposures with spirometry indices using linear regression. Results: Fifty-nine people (39.9%, 95%CI 31.9, 48.2) had abnormal spirometry; 72 (49.3%, 95%CI 40.9, 57.7) had a FEV₁ below the population mean. Pre-school hospitalisations for respiratory infections, younger maternal age, being overweight in early childhood and being born remotely were associated with reduced FEV₁ and FVC (absolute, %predicted and z-score). The association between maternal age and FEV₁ and FVC were stronger in women, as was hospitalization for respiratory infections before age 5. Being born remotely had a stronger association with reduced FEV₁ and FVC in men. Participants born in a remote community were over 6 times more likely to have a FEV₁ below the population mean (odds ratio [OR] 6.30, 95%CI 1.93, 20.59). Conclusion: Young Indigenous adults have a high prevalence of impaired lung function associated with several perinatal and early life factors, some of which are modifiable with feasible interventions.

Original language	English
Pages (from-to)	166-175
Number of pages	10
Journal	Respirology
Volume	29
Issue number	2
Early online date	Dec 2023
DOIs	https://doi.org/10.1111/resp.14639
Publication status	Published - Feb 2024

Bibliographical note

Funding Information:
The authors wish to acknowledge past and present study teams, and in particular Belinda Davison, Victor Oguoma and Dr Susan Sayers (AO), founder of the ABC study. We especially thank the young adults belonging to the Aboriginal Birth Cohort and their families and community for their co-operation and support and all the individuals who helped in the urban and rural locations. Open access publishing facilitated by Charles Darwin University, as part of the Wiley - Charles Darwin University agreement via the Council of Australian University Librarians.

Funding Information:
The Aboriginal Birth Cohort is supported by the National Health and Medical Research Council of Australia (Project Grant APP 1046391). Vidya Navaratnam is funded by a National Institute for Health Research (NIHR) Academic Clinical Lectureship. Anne B. Chang is supported by a NHMRC practitioner fellowship (grant 1154302) and holds multiple grants awarded from the NHMRC related to diseases associated with paediatric cough.

Publisher Copyright:
© 2023 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/resp.14639

93144789-oaFinal published version, 525 KBLicence: CC BY
93144789-oaE-pub ahead of print, 447 KBLicence: CC BY

Cite this

@article{64db633e6d8f47ab9816235d5bdc7505,

title = "Association between perinatal and early life exposures and lung function in Australian Indigenous young adults: The Aboriginal Birth Cohort study",

abstract = "Background and Objective: Despite the high burden of respiratory disease amongst Indigenous populations, prevalence data on spirometric deficits and its determinants are limited. We estimated the prevalence of abnormal spirometry in young Indigenous adults and determined its relationship with perinatal and early life factors. Methods: We used prospectively collected data from the Australian Aboriginal Birth Cohort, a birth cohort of 686 Indigenous Australian singletons. We calculated the proportion with abnormal spirometry (z-score <−1.64) and FEV1 below the population mean (FEV1% predicted 0 to −2SD) measured in young adulthood. We evaluated the association between perinatal and early life exposures with spirometry indices using linear regression. Results: Fifty-nine people (39.9%, 95%CI 31.9, 48.2) had abnormal spirometry; 72 (49.3%, 95%CI 40.9, 57.7) had a FEV1 below the population mean. Pre-school hospitalisations for respiratory infections, younger maternal age, being overweight in early childhood and being born remotely were associated with reduced FEV1 and FVC (absolute, %predicted and z-score). The association between maternal age and FEV1 and FVC were stronger in women, as was hospitalization for respiratory infections before age 5. Being born remotely had a stronger association with reduced FEV1 and FVC in men. Participants born in a remote community were over 6 times more likely to have a FEV1 below the population mean (odds ratio [OR] 6.30, 95%CI 1.93, 20.59). Conclusion: Young Indigenous adults have a high prevalence of impaired lung function associated with several perinatal and early life factors, some of which are modifiable with feasible interventions.",

keywords = "aboriginal adults, Australian Aboriginal Birth Cohort, cross-sectional study, early life risk factors, Indigenous adults, lung function, perinatal risk factors, spirometry",

author = "Vidya Navaratnam and Forrester, {Douglas L.} and Chang, {Anne B.} and Dharmage, {Shyamali C.} and Singh, {Gurmeet R.}",

note = "Funding Information: The authors wish to acknowledge past and present study teams, and in particular Belinda Davison, Victor Oguoma and Dr Susan Sayers (AO), founder of the ABC study. We especially thank the young adults belonging to the Aboriginal Birth Cohort and their families and community for their co-operation and support and all the individuals who helped in the urban and rural locations. Open access publishing facilitated by Charles Darwin University, as part of the Wiley - Charles Darwin University agreement via the Council of Australian University Librarians. Funding Information: The Aboriginal Birth Cohort is supported by the National Health and Medical Research Council of Australia (Project Grant APP 1046391). Vidya Navaratnam is funded by a National Institute for Health Research (NIHR) Academic Clinical Lectureship. Anne B. Chang is supported by a NHMRC practitioner fellowship (grant 1154302) and holds multiple grants awarded from the NHMRC related to diseases associated with paediatric cough. Publisher Copyright: {\textcopyright} 2023 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.",

year = "2024",

month = feb,

doi = "10.1111/resp.14639",

language = "English",

volume = "29",

pages = "166--175",

journal = "Respirology",

issn = "1323-7799",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Association between perinatal and early life exposures and lung function in Australian Indigenous young adults

T2 - The Aboriginal Birth Cohort study

AU - Navaratnam, Vidya

AU - Forrester, Douglas L.

AU - Chang, Anne B.

AU - Dharmage, Shyamali C.

AU - Singh, Gurmeet R.

N1 - Funding Information: The authors wish to acknowledge past and present study teams, and in particular Belinda Davison, Victor Oguoma and Dr Susan Sayers (AO), founder of the ABC study. We especially thank the young adults belonging to the Aboriginal Birth Cohort and their families and community for their co-operation and support and all the individuals who helped in the urban and rural locations. Open access publishing facilitated by Charles Darwin University, as part of the Wiley - Charles Darwin University agreement via the Council of Australian University Librarians. Funding Information: The Aboriginal Birth Cohort is supported by the National Health and Medical Research Council of Australia (Project Grant APP 1046391). Vidya Navaratnam is funded by a National Institute for Health Research (NIHR) Academic Clinical Lectureship. Anne B. Chang is supported by a NHMRC practitioner fellowship (grant 1154302) and holds multiple grants awarded from the NHMRC related to diseases associated with paediatric cough. Publisher Copyright: © 2023 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.

PY - 2024/2

Y1 - 2024/2

N2 - Background and Objective: Despite the high burden of respiratory disease amongst Indigenous populations, prevalence data on spirometric deficits and its determinants are limited. We estimated the prevalence of abnormal spirometry in young Indigenous adults and determined its relationship with perinatal and early life factors. Methods: We used prospectively collected data from the Australian Aboriginal Birth Cohort, a birth cohort of 686 Indigenous Australian singletons. We calculated the proportion with abnormal spirometry (z-score <−1.64) and FEV1 below the population mean (FEV1% predicted 0 to −2SD) measured in young adulthood. We evaluated the association between perinatal and early life exposures with spirometry indices using linear regression. Results: Fifty-nine people (39.9%, 95%CI 31.9, 48.2) had abnormal spirometry; 72 (49.3%, 95%CI 40.9, 57.7) had a FEV1 below the population mean. Pre-school hospitalisations for respiratory infections, younger maternal age, being overweight in early childhood and being born remotely were associated with reduced FEV1 and FVC (absolute, %predicted and z-score). The association between maternal age and FEV1 and FVC were stronger in women, as was hospitalization for respiratory infections before age 5. Being born remotely had a stronger association with reduced FEV1 and FVC in men. Participants born in a remote community were over 6 times more likely to have a FEV1 below the population mean (odds ratio [OR] 6.30, 95%CI 1.93, 20.59). Conclusion: Young Indigenous adults have a high prevalence of impaired lung function associated with several perinatal and early life factors, some of which are modifiable with feasible interventions.

AB - Background and Objective: Despite the high burden of respiratory disease amongst Indigenous populations, prevalence data on spirometric deficits and its determinants are limited. We estimated the prevalence of abnormal spirometry in young Indigenous adults and determined its relationship with perinatal and early life factors. Methods: We used prospectively collected data from the Australian Aboriginal Birth Cohort, a birth cohort of 686 Indigenous Australian singletons. We calculated the proportion with abnormal spirometry (z-score <−1.64) and FEV1 below the population mean (FEV1% predicted 0 to −2SD) measured in young adulthood. We evaluated the association between perinatal and early life exposures with spirometry indices using linear regression. Results: Fifty-nine people (39.9%, 95%CI 31.9, 48.2) had abnormal spirometry; 72 (49.3%, 95%CI 40.9, 57.7) had a FEV1 below the population mean. Pre-school hospitalisations for respiratory infections, younger maternal age, being overweight in early childhood and being born remotely were associated with reduced FEV1 and FVC (absolute, %predicted and z-score). The association between maternal age and FEV1 and FVC were stronger in women, as was hospitalization for respiratory infections before age 5. Being born remotely had a stronger association with reduced FEV1 and FVC in men. Participants born in a remote community were over 6 times more likely to have a FEV1 below the population mean (odds ratio [OR] 6.30, 95%CI 1.93, 20.59). Conclusion: Young Indigenous adults have a high prevalence of impaired lung function associated with several perinatal and early life factors, some of which are modifiable with feasible interventions.

KW - aboriginal adults

KW - Australian Aboriginal Birth Cohort

KW - cross-sectional study

KW - early life risk factors

KW - Indigenous adults

KW - lung function

KW - perinatal risk factors

KW - spirometry

UR - http://www.scopus.com/inward/record.url?scp=85179734548&partnerID=8YFLogxK

U2 - 10.1111/resp.14639

DO - 10.1111/resp.14639

M3 - Article

AN - SCOPUS:85179734548

SN - 1323-7799

VL - 29

SP - 166

EP - 175

JO - Respirology

JF - Respirology

IS - 2

ER -

Association between perinatal and early life exposures and lung function in Australian Indigenous young adults: The Aboriginal Birth Cohort study

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this