Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study

S Louise, N Warrington, P McCaskie, Wendy Oddy, Stephen Zubrick, Beth P Hands, T Mori, L Briollais, Sven Silburn, L Palmer, E Mattes, Lawrence Beilin

    Research output: Contribution to journalArticle

    Abstract

    Objective: To examine the influence of anxious/depressed scores on cardiovascular risk factors throughout childhood. 


    Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study, a study of 2900 pregnancies recruited between 1989 and 1991, were used. Anxious-depressed scores (derived from the Childhood Behavior Checklist), body mass index (BMI) and blood pressure were measured at 5 (n = 1681), 8 (n = 1697), 10 (n = 1575) and 14 (n = 1386) years. At age 14 depressive symptom scores (Beck Depression Inventory for Youth), anxious-depressed scores (Youth Self-Report (YSR) and Teacher Report Form (TRF)) and fasting lipid, glucose and insulin were also available. Cross sectional and longitudinal analyses were conducted. 


    Results: At age 14, girls with higher anxious-depressed scores had higher BMI (p≤0.005) and homeostasis model assessment-estimated insulin resistance (p≤0.0001). This equated to a difference of 0.6kg/m 2 and 0.3 units in predicted BMI and HOMA-IR respectively (top 5% vs. score of zero). Boys with higher anxious-depressed scores had lower systolic blood pressure trajectories (p=0.024). 


    Conclusion: Depressive scores appear to have differing influences on BMI, homeostasis model assessment-estimated insulin resistance and systolic blood pressure in boys and girls. Paradoxically boys with higher anxious-depressed scores had lower blood pressure throughout childhood. 

    Original languageEnglish
    Pages (from-to)345-350
    Number of pages6
    JournalPreventive Medicine
    Volume54
    Issue number5
    DOIs
    Publication statusPublished - 1 May 2012

      Fingerprint

    Cite this

    Louise, S., Warrington, N., McCaskie, P., Oddy, W., Zubrick, S., Hands, B. P., ... Beilin, L. (2012). Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study. Preventive Medicine, 54(5), 345-350. https://doi.org/10.1016/j.ypmed.2012.03.004