Abstract
Objective: To examine the influence of anxious/depressed scores on cardiovascular risk factors throughout childhood.
Methods: Data from the Western Australian Pregnancy Cohort (Raine)
Study, a study of 2900 pregnancies recruited between 1989 and 1991, were used.
Anxious-depressed scores (derived from the Childhood Behavior Checklist), body
mass index (BMI) and blood pressure were measured at 5 (n = 1681), 8 (n =
1697), 10 (n = 1575) and 14 (n = 1386) years. At age 14 depressive symptom
scores (Beck Depression Inventory for Youth), anxious-depressed scores (Youth
Self-Report (YSR) and Teacher Report Form (TRF)) and fasting lipid, glucose and
insulin were also available. Cross sectional and longitudinal analyses were
conducted.
Results: At age 14, girls with higher anxious-depressed scores
had higher BMI (p≤0.005) and homeostasis model assessment-estimated insulin
resistance (p≤0.0001). This equated to a difference of 0.6kg/m 2 and 0.3 units in predicted BMI and HOMA-IR respectively
(top 5% vs. score of zero). Boys with higher anxious-depressed scores had lower
systolic blood pressure trajectories (p=0.024).
Conclusion: Depressive scores appear to have differing influences on BMI,
homeostasis model assessment-estimated insulin resistance and systolic blood
pressure in boys and girls. Paradoxically boys with higher anxious-depressed
scores had lower blood pressure throughout childhood.
| Original language | English |
|---|---|
| Pages (from-to) | 345-350 |
| Number of pages | 6 |
| Journal | Preventive Medicine |
| Volume | 54 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 May 2012 |
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Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study. / Louise, S; Warrington, N; McCaskie, P; Oddy, Wendy; Zubrick, Stephen; Hands, Beth P; Mori, T; Briollais, L; Silburn, Sven; Palmer, L; Mattes, E; Beilin, Lawrence.
In: Preventive Medicine, Vol. 54, No. 5, 01.05.2012, p. 345-350.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study
AU - Louise, S
AU - Warrington, N
AU - McCaskie, P
AU - Oddy, Wendy
AU - Zubrick, Stephen
AU - Hands, Beth P
AU - Mori, T
AU - Briollais, L
AU - Silburn, Sven
AU - Palmer, L
AU - Mattes, E
AU - Beilin, Lawrence
PY - 2012/5/1
Y1 - 2012/5/1
N2 - Objective: To examine the influence of anxious/depressed scores on cardiovascular risk factors throughout childhood. Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study, a study of 2900 pregnancies recruited between 1989 and 1991, were used. Anxious-depressed scores (derived from the Childhood Behavior Checklist), body mass index (BMI) and blood pressure were measured at 5 (n = 1681), 8 (n = 1697), 10 (n = 1575) and 14 (n = 1386) years. At age 14 depressive symptom scores (Beck Depression Inventory for Youth), anxious-depressed scores (Youth Self-Report (YSR) and Teacher Report Form (TRF)) and fasting lipid, glucose and insulin were also available. Cross sectional and longitudinal analyses were conducted. Results: At age 14, girls with higher anxious-depressed scores had higher BMI (p≤0.005) and homeostasis model assessment-estimated insulin resistance (p≤0.0001). This equated to a difference of 0.6kg/m 2 and 0.3 units in predicted BMI and HOMA-IR respectively (top 5% vs. score of zero). Boys with higher anxious-depressed scores had lower systolic blood pressure trajectories (p=0.024). Conclusion: Depressive scores appear to have differing influences on BMI, homeostasis model assessment-estimated insulin resistance and systolic blood pressure in boys and girls. Paradoxically boys with higher anxious-depressed scores had lower blood pressure throughout childhood.
AB - Objective: To examine the influence of anxious/depressed scores on cardiovascular risk factors throughout childhood. Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study, a study of 2900 pregnancies recruited between 1989 and 1991, were used. Anxious-depressed scores (derived from the Childhood Behavior Checklist), body mass index (BMI) and blood pressure were measured at 5 (n = 1681), 8 (n = 1697), 10 (n = 1575) and 14 (n = 1386) years. At age 14 depressive symptom scores (Beck Depression Inventory for Youth), anxious-depressed scores (Youth Self-Report (YSR) and Teacher Report Form (TRF)) and fasting lipid, glucose and insulin were also available. Cross sectional and longitudinal analyses were conducted. Results: At age 14, girls with higher anxious-depressed scores had higher BMI (p≤0.005) and homeostasis model assessment-estimated insulin resistance (p≤0.0001). This equated to a difference of 0.6kg/m 2 and 0.3 units in predicted BMI and HOMA-IR respectively (top 5% vs. score of zero). Boys with higher anxious-depressed scores had lower systolic blood pressure trajectories (p=0.024). Conclusion: Depressive scores appear to have differing influences on BMI, homeostasis model assessment-estimated insulin resistance and systolic blood pressure in boys and girls. Paradoxically boys with higher anxious-depressed scores had lower blood pressure throughout childhood.
KW - adolescent
KW - anxiety disorder
KW - article
KW - Australia
KW - body mass
KW - cardiovascular risk
KW - child
KW - child behavior
KW - depression
KW - diastolic blood pressure
KW - female
KW - glucose blood level
KW - human
KW - insulin blood level
KW - lipid blood level
KW - major clinical study
KW - male
KW - preschool child
KW - priority journal
KW - school child
KW - systolic blood pressure
KW - triacylglycerol blood level
KW - Adolescent
KW - Anxiety Disorders
KW - Blood Pressure
KW - Body Mass Index
KW - Cardiovascular Diseases
KW - Checklist
KW - Child
KW - Child Behavior
KW - Child, Preschool
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Depression
KW - Female
KW - Homeostasis
KW - Humans
KW - Longitudinal Studies
KW - Male
KW - Personality Inventory
KW - Pregnancy
KW - Questionnaires
KW - Self Report
KW - Sex Distribution
KW - Western Australia
U2 - 10.1016/j.ypmed.2012.03.004
DO - 10.1016/j.ypmed.2012.03.004
M3 - Article
VL - 54
SP - 345
EP - 350
JO - Preventive Medicine
JF - Preventive Medicine
SN - 0091-7435
IS - 5
ER -