Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study

S Louise, N Warrington, P McCaskie, Wendy Oddy, Stephen Zubrick, Beth P Hands, T Mori, L Briollais, Sven Silburn, L Palmer, E Mattes, Lawrence Beilin

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Objective: To examine the influence of anxious/depressed scores on cardiovascular risk factors throughout childhood. 


    Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study, a study of 2900 pregnancies recruited between 1989 and 1991, were used. Anxious-depressed scores (derived from the Childhood Behavior Checklist), body mass index (BMI) and blood pressure were measured at 5 (n = 1681), 8 (n = 1697), 10 (n = 1575) and 14 (n = 1386) years. At age 14 depressive symptom scores (Beck Depression Inventory for Youth), anxious-depressed scores (Youth Self-Report (YSR) and Teacher Report Form (TRF)) and fasting lipid, glucose and insulin were also available. Cross sectional and longitudinal analyses were conducted. 


    Results: At age 14, girls with higher anxious-depressed scores had higher BMI (p≤0.005) and homeostasis model assessment-estimated insulin resistance (p≤0.0001). This equated to a difference of 0.6kg/m 2 and 0.3 units in predicted BMI and HOMA-IR respectively (top 5% vs. score of zero). Boys with higher anxious-depressed scores had lower systolic blood pressure trajectories (p=0.024). 


    Conclusion: Depressive scores appear to have differing influences on BMI, homeostasis model assessment-estimated insulin resistance and systolic blood pressure in boys and girls. Paradoxically boys with higher anxious-depressed scores had lower blood pressure throughout childhood. 

    Original languageEnglish
    Pages (from-to)345-350
    Number of pages6
    JournalPreventive Medicine
    Volume54
    Issue number5
    DOIs
    Publication statusPublished - 1 May 2012

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    Longitudinal Studies
    Blood Pressure
    Homeostasis
    Pregnancy
    Checklist
    Insulin Resistance
    Fasting
    Cohort Studies
    Cross-Sectional Studies
    Depression
    Lipids
    Glucose
    Equipment and Supplies

    Cite this

    Louise, S., Warrington, N., McCaskie, P., Oddy, W., Zubrick, S., Hands, B. P., ... Beilin, L. (2012). Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study. Preventive Medicine, 54(5), 345-350. https://doi.org/10.1016/j.ypmed.2012.03.004
    Louise, S ; Warrington, N ; McCaskie, P ; Oddy, Wendy ; Zubrick, Stephen ; Hands, Beth P ; Mori, T ; Briollais, L ; Silburn, Sven ; Palmer, L ; Mattes, E ; Beilin, Lawrence. / Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study. In: Preventive Medicine. 2012 ; Vol. 54, No. 5. pp. 345-350.
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    abstract = "Objective: To examine the influence of anxious/depressed scores on cardiovascular risk factors throughout childhood.  Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study, a study of 2900 pregnancies recruited between 1989 and 1991, were used. Anxious-depressed scores (derived from the Childhood Behavior Checklist), body mass index (BMI) and blood pressure were measured at 5 (n = 1681), 8 (n = 1697), 10 (n = 1575) and 14 (n = 1386) years. At age 14 depressive symptom scores (Beck Depression Inventory for Youth), anxious-depressed scores (Youth Self-Report (YSR) and Teacher Report Form (TRF)) and fasting lipid, glucose and insulin were also available. Cross sectional and longitudinal analyses were conducted.  Results: At age 14, girls with higher anxious-depressed scores had higher BMI (p≤0.005) and homeostasis model assessment-estimated insulin resistance (p≤0.0001). This equated to a difference of 0.6kg/m 2 and 0.3 units in predicted BMI and HOMA-IR respectively (top 5{\%} vs. score of zero). Boys with higher anxious-depressed scores had lower systolic blood pressure trajectories (p=0.024).  Conclusion: Depressive scores appear to have differing influences on BMI, homeostasis model assessment-estimated insulin resistance and systolic blood pressure in boys and girls. Paradoxically boys with higher anxious-depressed scores had lower blood pressure throughout childhood. ",
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    author = "S Louise and N Warrington and P McCaskie and Wendy Oddy and Stephen Zubrick and Hands, {Beth P} and T Mori and L Briollais and Sven Silburn and L Palmer and E Mattes and Lawrence Beilin",
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    Louise, S, Warrington, N, McCaskie, P, Oddy, W, Zubrick, S, Hands, BP, Mori, T, Briollais, L, Silburn, S, Palmer, L, Mattes, E & Beilin, L 2012, 'Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study', Preventive Medicine, vol. 54, no. 5, pp. 345-350. https://doi.org/10.1016/j.ypmed.2012.03.004

    Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study. / Louise, S; Warrington, N; McCaskie, P; Oddy, Wendy; Zubrick, Stephen; Hands, Beth P; Mori, T; Briollais, L; Silburn, Sven; Palmer, L; Mattes, E; Beilin, Lawrence.

    In: Preventive Medicine, Vol. 54, No. 5, 01.05.2012, p. 345-350.

    Research output: Contribution to journalArticleResearchpeer-review

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    T1 - Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study

    AU - Louise, S

    AU - Warrington, N

    AU - McCaskie, P

    AU - Oddy, Wendy

    AU - Zubrick, Stephen

    AU - Hands, Beth P

    AU - Mori, T

    AU - Briollais, L

    AU - Silburn, Sven

    AU - Palmer, L

    AU - Mattes, E

    AU - Beilin, Lawrence

    PY - 2012/5/1

    Y1 - 2012/5/1

    N2 - Objective: To examine the influence of anxious/depressed scores on cardiovascular risk factors throughout childhood.  Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study, a study of 2900 pregnancies recruited between 1989 and 1991, were used. Anxious-depressed scores (derived from the Childhood Behavior Checklist), body mass index (BMI) and blood pressure were measured at 5 (n = 1681), 8 (n = 1697), 10 (n = 1575) and 14 (n = 1386) years. At age 14 depressive symptom scores (Beck Depression Inventory for Youth), anxious-depressed scores (Youth Self-Report (YSR) and Teacher Report Form (TRF)) and fasting lipid, glucose and insulin were also available. Cross sectional and longitudinal analyses were conducted.  Results: At age 14, girls with higher anxious-depressed scores had higher BMI (p≤0.005) and homeostasis model assessment-estimated insulin resistance (p≤0.0001). This equated to a difference of 0.6kg/m 2 and 0.3 units in predicted BMI and HOMA-IR respectively (top 5% vs. score of zero). Boys with higher anxious-depressed scores had lower systolic blood pressure trajectories (p=0.024).  Conclusion: Depressive scores appear to have differing influences on BMI, homeostasis model assessment-estimated insulin resistance and systolic blood pressure in boys and girls. Paradoxically boys with higher anxious-depressed scores had lower blood pressure throughout childhood. 

    AB - Objective: To examine the influence of anxious/depressed scores on cardiovascular risk factors throughout childhood.  Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study, a study of 2900 pregnancies recruited between 1989 and 1991, were used. Anxious-depressed scores (derived from the Childhood Behavior Checklist), body mass index (BMI) and blood pressure were measured at 5 (n = 1681), 8 (n = 1697), 10 (n = 1575) and 14 (n = 1386) years. At age 14 depressive symptom scores (Beck Depression Inventory for Youth), anxious-depressed scores (Youth Self-Report (YSR) and Teacher Report Form (TRF)) and fasting lipid, glucose and insulin were also available. Cross sectional and longitudinal analyses were conducted.  Results: At age 14, girls with higher anxious-depressed scores had higher BMI (p≤0.005) and homeostasis model assessment-estimated insulin resistance (p≤0.0001). This equated to a difference of 0.6kg/m 2 and 0.3 units in predicted BMI and HOMA-IR respectively (top 5% vs. score of zero). Boys with higher anxious-depressed scores had lower systolic blood pressure trajectories (p=0.024).  Conclusion: Depressive scores appear to have differing influences on BMI, homeostasis model assessment-estimated insulin resistance and systolic blood pressure in boys and girls. Paradoxically boys with higher anxious-depressed scores had lower blood pressure throughout childhood. 

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