Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians

Kostas Kapellas, Lisa Jamieson, Loc Do, P. Mark Bartold, Hao Wang, Louise Maple-Brown, David Sullivan, Kerin O'Dea, Alex Brown, David S Celermajer, Gary Slade, Michael Skilton

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background/objectives: Inflammation is a key pathogenetic factor in atherogenesis. Periodontitis is a chronic inflammatory source which can have systemic impacts. Indigenous Australians have a higher prevalence of periodontal disease and experience cardiovascular disease earlier than non-Indigenous Australians. The aim was to describe the association between severity of periodontal inflammatory disease and measures of arterial structure and function.

Methods: 
Periodontal disease in a convenience sample of Indigenous Australians was assessed clinically; for those with periodontal disease, the extent of periodontal pockets ≥ 4 mm was stratified into quartiles. Vascular health was measured non-invasively via carotid-dorsalis pedis pulse-wave velocity (PWV), and via B-mode ultrasound of the common carotid intima-media (IMT). Non-fasting blood samples were collected for lipid and inflammatory marker evaluation. Linear regression models were constructed to determine the associations between extent of periodontal pocketing and vascular health, adjusting for traditional cardiovascular common risk factors.

Results: 
273 Indigenous Australian adults were recruited and complete data was available for 269 participants (154 males), median age 39 years. Arterial stiffness (PWV) significantly increased with increasing extent of periodontal pocketing (p trend = 0.001). By contrast, carotid IMT did not differ across quartiles.

Conclusions: 
Periodontal pocketing was associated with central arterial stiffness, a marker of presymptomatic arterial dysfunction, in Indigenous Australian adults with periodontal disease.
Original languageEnglish
Pages (from-to)190-196
Number of pages7
JournalInternational Journal of Cardiology
Volume173
Issue number2
DOIs
Publication statusPublished - 1 May 2014

Fingerprint

Periodontal Diseases
Pulse Wave Analysis
Vascular Stiffness
Blood Vessels
Linear Models
Periodontal Pocket
Periodontitis
Health
Atherosclerosis
Cardiovascular Diseases
Inflammation
Lipids

Cite this

Kapellas, Kostas ; Jamieson, Lisa ; Do, Loc ; Bartold, P. Mark ; Wang, Hao ; Maple-Brown, Louise ; Sullivan, David ; O'Dea, Kerin ; Brown, Alex ; Celermajer, David S ; Slade, Gary ; Skilton, Michael. / Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians. In: International Journal of Cardiology. 2014 ; Vol. 173, No. 2. pp. 190-196.
@article{5c956495f2724f8bb78b7739761b70d9,
title = "Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians",
abstract = "Background/objectives: Inflammation is a key pathogenetic factor in atherogenesis. Periodontitis is a chronic inflammatory source which can have systemic impacts. Indigenous Australians have a higher prevalence of periodontal disease and experience cardiovascular disease earlier than non-Indigenous Australians. The aim was to describe the association between severity of periodontal inflammatory disease and measures of arterial structure and function.Methods: Periodontal disease in a convenience sample of Indigenous Australians was assessed clinically; for those with periodontal disease, the extent of periodontal pockets ≥ 4 mm was stratified into quartiles. Vascular health was measured non-invasively via carotid-dorsalis pedis pulse-wave velocity (PWV), and via B-mode ultrasound of the common carotid intima-media (IMT). Non-fasting blood samples were collected for lipid and inflammatory marker evaluation. Linear regression models were constructed to determine the associations between extent of periodontal pocketing and vascular health, adjusting for traditional cardiovascular common risk factors.Results: 273 Indigenous Australian adults were recruited and complete data was available for 269 participants (154 males), median age 39 years. Arterial stiffness (PWV) significantly increased with increasing extent of periodontal pocketing (p trend = 0.001). By contrast, carotid IMT did not differ across quartiles.Conclusions: Periodontal pocketing was associated with central arterial stiffness, a marker of presymptomatic arterial dysfunction, in Indigenous Australian adults with periodontal disease.",
keywords = "apolipoprotein A1, apolipoprotein B, C reactive protein, high density lipoprotein cholesterol, interleukin 6, n(g),n(g) dimethylarginine, adult, arterial stiffness, arterial wall thickness, article, atherogenesis, Australia, B scan, blood pressure measurement, body mass, cardiovascular disease, cardiovascular risk, cholesterol blood level, clinical assessment, controlled study, disease association, disease marker, disease severity, female, gingiva bleeding, human, indigenous people, major clinical study, male, periodontitis, prevalence, priority journal, pulse wave, smoking, urinalysis, aged, Australia and New Zealand, echography, epidemiology, ethnology, immunology, middle aged, non insulin dependent diabetes mellitus, Oceanic ancestry group, pulsatile flow, risk factor, statistical model, statistics and numerical data, young adult, Adult, Aged, Australasia, Cardiovascular Diseases, Carotid Intima-Media Thickness, Diabetes Mellitus, Type 2, Female, Humans, Linear Models, Male, Middle Aged, Oceanic Ancestry Group, Periodontitis, Prevalence, Pulsatile Flow, Risk Factors, Smoking, Vascular Stiffness, Young Adult",
author = "Kostas Kapellas and Lisa Jamieson and Loc Do and Bartold, {P. Mark} and Hao Wang and Louise Maple-Brown and David Sullivan and Kerin O'Dea and Alex Brown and Celermajer, {David S} and Gary Slade and Michael Skilton",
year = "2014",
month = "5",
day = "1",
doi = "10.1016/j.ijcard.2014.02.015",
language = "English",
volume = "173",
pages = "190--196",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier",
number = "2",

}

Kapellas, K, Jamieson, L, Do, L, Bartold, PM, Wang, H, Maple-Brown, L, Sullivan, D, O'Dea, K, Brown, A, Celermajer, DS, Slade, G & Skilton, M 2014, 'Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians', International Journal of Cardiology, vol. 173, no. 2, pp. 190-196. https://doi.org/10.1016/j.ijcard.2014.02.015

Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians. / Kapellas, Kostas; Jamieson, Lisa; Do, Loc; Bartold, P. Mark; Wang, Hao; Maple-Brown, Louise; Sullivan, David; O'Dea, Kerin; Brown, Alex; Celermajer, David S; Slade, Gary; Skilton, Michael.

In: International Journal of Cardiology, Vol. 173, No. 2, 01.05.2014, p. 190-196.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians

AU - Kapellas, Kostas

AU - Jamieson, Lisa

AU - Do, Loc

AU - Bartold, P. Mark

AU - Wang, Hao

AU - Maple-Brown, Louise

AU - Sullivan, David

AU - O'Dea, Kerin

AU - Brown, Alex

AU - Celermajer, David S

AU - Slade, Gary

AU - Skilton, Michael

PY - 2014/5/1

Y1 - 2014/5/1

N2 - Background/objectives: Inflammation is a key pathogenetic factor in atherogenesis. Periodontitis is a chronic inflammatory source which can have systemic impacts. Indigenous Australians have a higher prevalence of periodontal disease and experience cardiovascular disease earlier than non-Indigenous Australians. The aim was to describe the association between severity of periodontal inflammatory disease and measures of arterial structure and function.Methods: Periodontal disease in a convenience sample of Indigenous Australians was assessed clinically; for those with periodontal disease, the extent of periodontal pockets ≥ 4 mm was stratified into quartiles. Vascular health was measured non-invasively via carotid-dorsalis pedis pulse-wave velocity (PWV), and via B-mode ultrasound of the common carotid intima-media (IMT). Non-fasting blood samples were collected for lipid and inflammatory marker evaluation. Linear regression models were constructed to determine the associations between extent of periodontal pocketing and vascular health, adjusting for traditional cardiovascular common risk factors.Results: 273 Indigenous Australian adults were recruited and complete data was available for 269 participants (154 males), median age 39 years. Arterial stiffness (PWV) significantly increased with increasing extent of periodontal pocketing (p trend = 0.001). By contrast, carotid IMT did not differ across quartiles.Conclusions: Periodontal pocketing was associated with central arterial stiffness, a marker of presymptomatic arterial dysfunction, in Indigenous Australian adults with periodontal disease.

AB - Background/objectives: Inflammation is a key pathogenetic factor in atherogenesis. Periodontitis is a chronic inflammatory source which can have systemic impacts. Indigenous Australians have a higher prevalence of periodontal disease and experience cardiovascular disease earlier than non-Indigenous Australians. The aim was to describe the association between severity of periodontal inflammatory disease and measures of arterial structure and function.Methods: Periodontal disease in a convenience sample of Indigenous Australians was assessed clinically; for those with periodontal disease, the extent of periodontal pockets ≥ 4 mm was stratified into quartiles. Vascular health was measured non-invasively via carotid-dorsalis pedis pulse-wave velocity (PWV), and via B-mode ultrasound of the common carotid intima-media (IMT). Non-fasting blood samples were collected for lipid and inflammatory marker evaluation. Linear regression models were constructed to determine the associations between extent of periodontal pocketing and vascular health, adjusting for traditional cardiovascular common risk factors.Results: 273 Indigenous Australian adults were recruited and complete data was available for 269 participants (154 males), median age 39 years. Arterial stiffness (PWV) significantly increased with increasing extent of periodontal pocketing (p trend = 0.001). By contrast, carotid IMT did not differ across quartiles.Conclusions: Periodontal pocketing was associated with central arterial stiffness, a marker of presymptomatic arterial dysfunction, in Indigenous Australian adults with periodontal disease.

KW - apolipoprotein A1

KW - apolipoprotein B

KW - C reactive protein

KW - high density lipoprotein cholesterol

KW - interleukin 6

KW - n(g),n(g) dimethylarginine

KW - adult

KW - arterial stiffness

KW - arterial wall thickness

KW - article

KW - atherogenesis

KW - Australia

KW - B scan

KW - blood pressure measurement

KW - body mass

KW - cardiovascular disease

KW - cardiovascular risk

KW - cholesterol blood level

KW - clinical assessment

KW - controlled study

KW - disease association

KW - disease marker

KW - disease severity

KW - female

KW - gingiva bleeding

KW - human

KW - indigenous people

KW - major clinical study

KW - male

KW - periodontitis

KW - prevalence

KW - priority journal

KW - pulse wave

KW - smoking

KW - urinalysis

KW - aged

KW - Australia and New Zealand

KW - echography

KW - epidemiology

KW - ethnology

KW - immunology

KW - middle aged

KW - non insulin dependent diabetes mellitus

KW - Oceanic ancestry group

KW - pulsatile flow

KW - risk factor

KW - statistical model

KW - statistics and numerical data

KW - young adult

KW - Adult

KW - Aged

KW - Australasia

KW - Cardiovascular Diseases

KW - Carotid Intima-Media Thickness

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Oceanic Ancestry Group

KW - Periodontitis

KW - Prevalence

KW - Pulsatile Flow

KW - Risk Factors

KW - Smoking

KW - Vascular Stiffness

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=84898894935&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2014.02.015

DO - 10.1016/j.ijcard.2014.02.015

M3 - Article

VL - 173

SP - 190

EP - 196

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 2

ER -