Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians

Kostas Kapellas, Lisa Jamieson, Loc Do, P. Mark Bartold, Hao Wang, Louise Maple-Brown, David Sullivan, Kerin O'Dea, Alex Brown, David S Celermajer, Gary Slade, Michael Skilton

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Background/objectives: Inflammation is a key pathogenetic factor in atherogenesis. Periodontitis is a chronic inflammatory source which can have systemic impacts. Indigenous Australians have a higher prevalence of periodontal disease and experience cardiovascular disease earlier than non-Indigenous Australians. The aim was to describe the association between severity of periodontal inflammatory disease and measures of arterial structure and function.

    Methods: 
    Periodontal disease in a convenience sample of Indigenous Australians was assessed clinically; for those with periodontal disease, the extent of periodontal pockets ≥ 4 mm was stratified into quartiles. Vascular health was measured non-invasively via carotid-dorsalis pedis pulse-wave velocity (PWV), and via B-mode ultrasound of the common carotid intima-media (IMT). Non-fasting blood samples were collected for lipid and inflammatory marker evaluation. Linear regression models were constructed to determine the associations between extent of periodontal pocketing and vascular health, adjusting for traditional cardiovascular common risk factors.

    Results: 
    273 Indigenous Australian adults were recruited and complete data was available for 269 participants (154 males), median age 39 years. Arterial stiffness (PWV) significantly increased with increasing extent of periodontal pocketing (p trend = 0.001). By contrast, carotid IMT did not differ across quartiles.

    Conclusions: 
    Periodontal pocketing was associated with central arterial stiffness, a marker of presymptomatic arterial dysfunction, in Indigenous Australian adults with periodontal disease.
    Original languageEnglish
    Pages (from-to)190-196
    Number of pages7
    JournalInternational Journal of Cardiology
    Volume173
    Issue number2
    DOIs
    Publication statusPublished - 1 May 2014

    Fingerprint

    Periodontal Diseases
    Pulse Wave Analysis
    Vascular Stiffness
    Blood Vessels
    Linear Models
    Periodontal Pocket
    Periodontitis
    Health
    Atherosclerosis
    Cardiovascular Diseases
    Inflammation
    Lipids

    Cite this

    Kapellas, Kostas ; Jamieson, Lisa ; Do, Loc ; Bartold, P. Mark ; Wang, Hao ; Maple-Brown, Louise ; Sullivan, David ; O'Dea, Kerin ; Brown, Alex ; Celermajer, David S ; Slade, Gary ; Skilton, Michael. / Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians. In: International Journal of Cardiology. 2014 ; Vol. 173, No. 2. pp. 190-196.
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    abstract = "Background/objectives: Inflammation is a key pathogenetic factor in atherogenesis. Periodontitis is a chronic inflammatory source which can have systemic impacts. Indigenous Australians have a higher prevalence of periodontal disease and experience cardiovascular disease earlier than non-Indigenous Australians. The aim was to describe the association between severity of periodontal inflammatory disease and measures of arterial structure and function.Methods: Periodontal disease in a convenience sample of Indigenous Australians was assessed clinically; for those with periodontal disease, the extent of periodontal pockets ≥ 4 mm was stratified into quartiles. Vascular health was measured non-invasively via carotid-dorsalis pedis pulse-wave velocity (PWV), and via B-mode ultrasound of the common carotid intima-media (IMT). Non-fasting blood samples were collected for lipid and inflammatory marker evaluation. Linear regression models were constructed to determine the associations between extent of periodontal pocketing and vascular health, adjusting for traditional cardiovascular common risk factors.Results: 273 Indigenous Australian adults were recruited and complete data was available for 269 participants (154 males), median age 39 years. Arterial stiffness (PWV) significantly increased with increasing extent of periodontal pocketing (p trend = 0.001). By contrast, carotid IMT did not differ across quartiles.Conclusions: Periodontal pocketing was associated with central arterial stiffness, a marker of presymptomatic arterial dysfunction, in Indigenous Australian adults with periodontal disease.",
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    author = "Kostas Kapellas and Lisa Jamieson and Loc Do and Bartold, {P. Mark} and Hao Wang and Louise Maple-Brown and David Sullivan and Kerin O'Dea and Alex Brown and Celermajer, {David S} and Gary Slade and Michael Skilton",
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    Kapellas, K, Jamieson, L, Do, L, Bartold, PM, Wang, H, Maple-Brown, L, Sullivan, D, O'Dea, K, Brown, A, Celermajer, DS, Slade, G & Skilton, M 2014, 'Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians', International Journal of Cardiology, vol. 173, no. 2, pp. 190-196. https://doi.org/10.1016/j.ijcard.2014.02.015

    Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians. / Kapellas, Kostas; Jamieson, Lisa; Do, Loc; Bartold, P. Mark; Wang, Hao; Maple-Brown, Louise; Sullivan, David; O'Dea, Kerin; Brown, Alex; Celermajer, David S; Slade, Gary; Skilton, Michael.

    In: International Journal of Cardiology, Vol. 173, No. 2, 01.05.2014, p. 190-196.

    Research output: Contribution to journalArticleResearchpeer-review

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    AU - Slade, Gary

    AU - Skilton, Michael

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