Asymptomatic and submicroscopic carriage of plasmodium knowlesi malaria in household and community members of clinical cases in sabah, Malaysia

Kimberly M. Fornace, Nor Afizah Nuin, Martha Betson, Matthew J. Grigg, Timothy WILLIAM, Nicholas M. Anstey, Tsin W. Yeo, Jonathan Cox, Lau Tiek Ying, Chris J. Drakeley

    Research output: Contribution to journalArticle

    Abstract

    Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

    Original languageEnglish
    Pages (from-to)784-787
    Number of pages4
    JournalJournal of Infectious Diseases
    Volume213
    Issue number5
    Early online date2015
    DOIs
    Publication statusPublished - 2016

    Fingerprint Dive into the research topics of 'Asymptomatic and submicroscopic carriage of plasmodium knowlesi malaria in household and community members of clinical cases in sabah, Malaysia'. Together they form a unique fingerprint.

  • Cite this