Asymptomatic and submicroscopic carriage of plasmodium knowlesi malaria in household and community members of clinical cases in sabah, Malaysia

Kimberly M. Fornace, Nor Afizah Nuin, Martha Betson, Matthew J. Grigg, Timothy WILLIAM, Nicholas M. Anstey, Tsin W. Yeo, Jonathan Cox, Lau Tiek Ying, Chris J. Drakeley

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

    Original languageEnglish
    Pages (from-to)784-787
    Number of pages4
    JournalJournal of Infectious Diseases
    Volume213
    Issue number5
    Early online date2015
    DOIs
    Publication statusPublished - 2016

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    Plasmodium knowlesi
    Plasmodium malariae
    Malaysia
    Malaria
    Parasitemia
    Age Groups
    Confidence Intervals
    Population

    Cite this

    Fornace, Kimberly M. ; Nuin, Nor Afizah ; Betson, Martha ; Grigg, Matthew J. ; WILLIAM, Timothy ; Anstey, Nicholas M. ; Yeo, Tsin W. ; Cox, Jonathan ; Ying, Lau Tiek ; Drakeley, Chris J. / Asymptomatic and submicroscopic carriage of plasmodium knowlesi malaria in household and community members of clinical cases in sabah, Malaysia. In: Journal of Infectious Diseases. 2016 ; Vol. 213, No. 5. pp. 784-787.
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    title = "Asymptomatic and submicroscopic carriage of plasmodium knowlesi malaria in household and community members of clinical cases in sabah, Malaysia",
    abstract = "Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9{\%} (95{\%} confidence interval, 5.6{\%}-8.4{\%}). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.",
    keywords = "Asymptomatic parasitemia, Malaria, Plasmodium knowlesi, Submicroscopic infection",
    author = "Fornace, {Kimberly M.} and Nuin, {Nor Afizah} and Martha Betson and Grigg, {Matthew J.} and Timothy WILLIAM and Anstey, {Nicholas M.} and Yeo, {Tsin W.} and Jonathan Cox and Ying, {Lau Tiek} and Drakeley, {Chris J.}",
    year = "2016",
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    language = "English",
    volume = "213",
    pages = "784--787",
    journal = "Journal of Infectious Diseases",
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    Asymptomatic and submicroscopic carriage of plasmodium knowlesi malaria in household and community members of clinical cases in sabah, Malaysia. / Fornace, Kimberly M.; Nuin, Nor Afizah; Betson, Martha; Grigg, Matthew J.; WILLIAM, Timothy; Anstey, Nicholas M.; Yeo, Tsin W.; Cox, Jonathan; Ying, Lau Tiek; Drakeley, Chris J.

    In: Journal of Infectious Diseases, Vol. 213, No. 5, 2016, p. 784-787.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Asymptomatic and submicroscopic carriage of plasmodium knowlesi malaria in household and community members of clinical cases in sabah, Malaysia

    AU - Fornace, Kimberly M.

    AU - Nuin, Nor Afizah

    AU - Betson, Martha

    AU - Grigg, Matthew J.

    AU - WILLIAM, Timothy

    AU - Anstey, Nicholas M.

    AU - Yeo, Tsin W.

    AU - Cox, Jonathan

    AU - Ying, Lau Tiek

    AU - Drakeley, Chris J.

    PY - 2016

    Y1 - 2016

    N2 - Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

    AB - Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

    KW - Asymptomatic parasitemia

    KW - Malaria

    KW - Plasmodium knowlesi

    KW - Submicroscopic infection

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