Asymptomatic and submicroscopic carriage of plasmodium knowlesi malaria in household and community members of clinical cases in sabah, Malaysia

Kimberly M. Fornace; Nor Afizah Nuin; Martha Betson; Matthew J. Grigg; Timothy WILLIAM; Nicholas M. Anstey; Tsin W. Yeo; Jonathan Cox; Lau Tiek Ying; Chris J. Drakeley

doi:10.1093/infdis/jiv475

Asymptomatic and submicroscopic carriage of plasmodium knowlesi malaria in household and community members of clinical cases in sabah, Malaysia

Kimberly M. Fornace, Nor Afizah Nuin, Martha Betson, Matthew J. Grigg, Timothy WILLIAM, Nicholas M. Anstey, Tsin W. Yeo, Jonathan Cox, Lau Tiek Ying, Chris J. Drakeley

Research output: Contribution to journal › Article › peer-review

Abstract

Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

Original language	English
Pages (from-to)	784-787
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	213
Issue number	5
Early online date	2015
DOIs	https://doi.org/10.1093/infdis/jiv475
Publication status	Published - 2016

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Fornace, K. M., Nuin, N. A., Betson, M., Grigg, M. J., WILLIAM, T., Anstey, N. M., Yeo, T. W., Cox, J., Ying, L. T., & Drakeley, C. J. (2016). Asymptomatic and submicroscopic carriage of plasmodium knowlesi malaria in household and community members of clinical cases in sabah, Malaysia. Journal of Infectious Diseases, 213(5), 784-787. https://doi.org/10.1093/infdis/jiv475

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title = "Asymptomatic and submicroscopic carriage of plasmodium knowlesi malaria in household and community members of clinical cases in sabah, Malaysia",

abstract = "Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.",

keywords = "Asymptomatic parasitemia, Malaria, Plasmodium knowlesi, Submicroscopic infection",

author = "Fornace, {Kimberly M.} and Nuin, {Nor Afizah} and Martha Betson and Grigg, {Matthew J.} and Timothy WILLIAM and Anstey, {Nicholas M.} and Yeo, {Tsin W.} and Jonathan Cox and Ying, {Lau Tiek} and Drakeley, {Chris J.}",

year = "2016",

doi = "10.1093/infdis/jiv475",

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AU - Fornace, Kimberly M.

AU - Nuin, Nor Afizah

AU - Betson, Martha

AU - Grigg, Matthew J.

AU - WILLIAM, Timothy

AU - Anstey, Nicholas M.

AU - Yeo, Tsin W.

AU - Cox, Jonathan

AU - Ying, Lau Tiek

AU - Drakeley, Chris J.

PY - 2016

Y1 - 2016

N2 - Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

AB - Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

KW - Asymptomatic parasitemia

KW - Malaria

KW - Plasmodium knowlesi

KW - Submicroscopic infection

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DO - 10.1093/infdis/jiv475

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EP - 787

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

SN - 0022-1899

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ER -

Asymptomatic and submicroscopic carriage of plasmodium knowlesi malaria in household and community members of clinical cases in sabah, Malaysia

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