Asymptomatic and submicroscopic carriage of Plasmodium knowlesi malaria in household and community members of clinical cases in Sabah, Malaysia

Kimberly M. Fornace, Nor Afizah Nuin, Martha Betson, Matthew J. Grigg, Timothy WILLIAM, Nicholas M. Anstey, Tsin W. Yeo, Jonathan Cox, Lau Tiek Ying, Chris J. Drakeley

Research output: Contribution to journalArticlepeer-review

Abstract

Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

Original languageEnglish
Pages (from-to)784-787
Number of pages4
JournalJournal of Infectious Diseases
Volume213
Issue number5
Early online date2015
DOIs
Publication statusPublished - 2016

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