Bacteremia, Sepsis, and Infective Endocarditis Associated with Staphylococcus aureus

Stephen P. Bergin, Thomas L Holland, Vance Fowler Jr, Steven Tong

    Research output: Chapter in Book/Report/Conference proceedingChapter


    Bacteremia and infective endocarditis (IE) are important causes of morbidity and mortality associated with Staphylococcus aureus infections. Increasing exposure to healthcare, invasive procedures, and prosthetic implants has been associated with a rising incidence of S. aureus bacteremia (SAB) and IE since the late twentieth century. S. aureus is now the most common cause of bacteremia and IE in industrialized nations worldwide and is associated with excess mortality when compared to other pathogens. Central tenets of management include identification of complicated bacteremia, eradicating foci of infection, and, for many, prolonged antimicrobial therapy. Evolving multidrug resistance and limited therapeutic options highlight the many unanswered clinical questions and urgent need for further high-quality clinical research.
    Original languageEnglish
    Title of host publicationStaphylococcus aureus
    Subtitle of host publicationMicrobiology, Pathology, Immunology, Therapy and Prophylaxis
    EditorsFabio Bagnoli, Rino Rappuoli, Guido Grandi
    Place of PublicationBerlin, Germany
    Number of pages34
    ISBN (Electronic)978-3-319-72063-0
    ISBN (Print)978-3-319-72061-6
    Publication statusPublished - 2015

    Publication series

    NameCurrent Topics in Microbiology and Immunology


    Cite this

    Bergin, S. P., Holland, T. L., Fowler Jr, V., & Tong, S. (2015). Bacteremia, Sepsis, and Infective Endocarditis Associated with Staphylococcus aureus. In F. Bagnoli, R. Rappuoli, & G. Grandi (Eds.), Staphylococcus aureus: Microbiology, Pathology, Immunology, Therapy and Prophylaxis (pp. 263-296). (Current Topics in Microbiology and Immunology; Vol. 409). Berlin, Germany: Springer.