Bilateral diffuse pulmonary infiltrates secondary to malignant peritoneal mesothelioma – A rare clinical presentation

Madeleine Haygarth; Kyi Kyi Zaw; Victoria Yachmenikova; Adrian M.J. Pokorny; Kin Keung Kwong; Subash S. Heraganahally

doi:10.1016/j.rmcr.2019.03.003

Bilateral diffuse pulmonary infiltrates secondary to malignant peritoneal mesothelioma – A rare clinical presentation

Madeleine Haygarth, Kyi Kyi Zaw, Victoria Yachmenikova, Adrian M.J. Pokorny, Kin Keung Kwong, Subash S. Heraganahally

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Abstract

Diffuse pulmonary metastasis secondary to primary peritoneal malignant mesothelioma is rarely reported in the literature. In this report we describe a 59-year-old Caucasian women with no known previous asbestos exposure presenting with bilateral diffuse pulmonary opacities in association with primary malignant peritoneal mesothelioma. The diagnosis was confirmed by ultrasound guided abdominal and bronchoscopy, trans-bronchial lung biopsy. The biopsy demonstrated positive staining with AE1/3, CK7, CK5/6, WT1, calretinin and D2 40. The cells were negative for BerEP4, PAX8, CA125, ER, CD34, ERG, P63, P40, Melan A, Gata3 and mammaglobin. The morphology and immunohistochemical profile supported a diagnosis of epithelioid malignant mesothelioma.

Original language	English
Pages (from-to)	326-327
Number of pages	2
Journal	Respiratory Medicine Case Reports
Volume	26
DOIs	https://doi.org/10.1016/j.rmcr.2019.03.003
Publication status	Published - 1 Jan 2019
Externally published	Yes

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title = "Bilateral diffuse pulmonary infiltrates secondary to malignant peritoneal mesothelioma – A rare clinical presentation",

abstract = "Diffuse pulmonary metastasis secondary to primary peritoneal malignant mesothelioma is rarely reported in the literature. In this report we describe a 59-year-old Caucasian women with no known previous asbestos exposure presenting with bilateral diffuse pulmonary opacities in association with primary malignant peritoneal mesothelioma. The diagnosis was confirmed by ultrasound guided abdominal and bronchoscopy, trans-bronchial lung biopsy. The biopsy demonstrated positive staining with AE1/3, CK7, CK5/6, WT1, calretinin and D2 40. The cells were negative for BerEP4, PAX8, CA125, ER, CD34, ERG, P63, P40, Melan A, Gata3 and mammaglobin. The morphology and immunohistochemical profile supported a diagnosis of epithelioid malignant mesothelioma.",

keywords = "Asbestos, Malignant mesothelioma, Peritoneal mesothelioma, Pleural effusion, Trans-bronchial lung biopsy",

author = "Madeleine Haygarth and Zaw, {Kyi Kyi} and Victoria Yachmenikova and Pokorny, {Adrian M.J.} and Kwong, {Kin Keung} and Heraganahally, {Subash S.}",

year = "2019",

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Bilateral diffuse pulmonary infiltrates secondary to malignant peritoneal mesothelioma – A rare clinical presentation. / Haygarth, Madeleine; Zaw, Kyi Kyi; Yachmenikova, Victoria; Pokorny, Adrian M.J.; Kwong, Kin Keung; Heraganahally, Subash S.

In: Respiratory Medicine Case Reports, Vol. 26, 01.01.2019, p. 326-327.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Bilateral diffuse pulmonary infiltrates secondary to malignant peritoneal mesothelioma – A rare clinical presentation

AU - Haygarth, Madeleine

AU - Zaw, Kyi Kyi

AU - Yachmenikova, Victoria

AU - Pokorny, Adrian M.J.

AU - Kwong, Kin Keung

AU - Heraganahally, Subash S.

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N2 - Diffuse pulmonary metastasis secondary to primary peritoneal malignant mesothelioma is rarely reported in the literature. In this report we describe a 59-year-old Caucasian women with no known previous asbestos exposure presenting with bilateral diffuse pulmonary opacities in association with primary malignant peritoneal mesothelioma. The diagnosis was confirmed by ultrasound guided abdominal and bronchoscopy, trans-bronchial lung biopsy. The biopsy demonstrated positive staining with AE1/3, CK7, CK5/6, WT1, calretinin and D2 40. The cells were negative for BerEP4, PAX8, CA125, ER, CD34, ERG, P63, P40, Melan A, Gata3 and mammaglobin. The morphology and immunohistochemical profile supported a diagnosis of epithelioid malignant mesothelioma.

AB - Diffuse pulmonary metastasis secondary to primary peritoneal malignant mesothelioma is rarely reported in the literature. In this report we describe a 59-year-old Caucasian women with no known previous asbestos exposure presenting with bilateral diffuse pulmonary opacities in association with primary malignant peritoneal mesothelioma. The diagnosis was confirmed by ultrasound guided abdominal and bronchoscopy, trans-bronchial lung biopsy. The biopsy demonstrated positive staining with AE1/3, CK7, CK5/6, WT1, calretinin and D2 40. The cells were negative for BerEP4, PAX8, CA125, ER, CD34, ERG, P63, P40, Melan A, Gata3 and mammaglobin. The morphology and immunohistochemical profile supported a diagnosis of epithelioid malignant mesothelioma.

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